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- W4362664595 endingPage "2023" @default.
- W4362664595 startingPage "00046" @default.
- W4362664595 abstract "Few studies exist investigating lung function trajectories of those born preterm; however growing evidence suggests some individuals experience increasing airway obstruction throughout life. Here we use the studies identified in a recent systematic review to provide the first meta-analysis investigating the impact of preterm birth on airway obstruction measured by the forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio.Cohorts were included for analysis if they reported FEV1/FVC in survivors of preterm birth (<37 weeks' gestation) and control populations born at term. Meta-analysis was performed using a random effect model, expressed as standardised mean difference (SMD). Meta-regression was conducted using age and birth year as moderators.55 cohorts were eligible, 35 of which defined groups with bronchopulmonary dysplasia (BPD). Compared to control populations born at term, lower values of FEV1/FVC were seen in all individuals born preterm (SMD -0.56), with greater differences seen in those with BPD (SMD -0.87) than those without BPD (SMD -0.45). Meta-regression identified age as a significant predictor of FEV1/FVC in those with BPD with the FEV1/FVC ratio moving -0.04 sds away from the term control population for every year of increased age.Survivors of preterm birth have significantly increased airway obstruction compared to those born at term with larger differences in those with BPD. Increased age is associated with a decline in FEV1/FVC values suggesting increased airway obstruction over the life course." @default.
- W4362664595 created "2023-04-07" @default.
- W4362664595 creator A5008739147 @default.
- W4362664595 creator A5047107436 @default.
- W4362664595 creator A5051875002 @default.
- W4362664595 creator A5067149532 @default.
- W4362664595 creator A5071655232 @default.
- W4362664595 date "2023-04-06" @default.
- W4362664595 modified "2023-09-27" @default.
- W4362664595 title "Increasing airway obstruction through life following bronchopulmonary dysplasia: a meta-analysis" @default.
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