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• W4362665362 abstract "Abstract Background: Recently, plant-derived exosome-like nanoparticles (ELNs) have drawn much attention for oral prevention and treatment of colonic diseases. However, the roles of ELNs derived from garlic ( Allium sativum L.)., which is widely documented for treating dysentery in Chinese medicine, on colitis remain largely unknown. Results: We demonstrate that garlic ELNs (GELNs), with desirable particle sizes (79.60 nm) trafficking large amounts of functional proteins and miRNAs, stably roam in the gut and confer protection against ulcerative colitis. In DSS-induced colitis mice, orally administered GELNs effectively ameliorated bloody diarrhea, normalized the production of proinflammatory cytokines, and prevented colonic barrier impairment. Mechanistically, GELNs were taken up by gut microbes and reshaped DSS-induced gut microbiota dysbiosis, in which Bacteroides served as the dominant respondent genus upon GELNs treatment. Of note, peu-MIR2916-p3, one of the most abundant miRNAs in GELNs, specifically promoted the growth of Bacteroides thetaiotaomicron , an intestinal symbiotic bacterium with palliative effect on colitis. Conclusion: Our findings provide new insights for the application of GELNs and highlight the potential of GELNs as natural nanotherapeutic agents for preventing and treating ulcerative colitis." @default.
• W4362665362 created "2023-04-07" @default.
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• W4362665362 date "2023-04-06" @default.
• W4362665362 modified "2023-10-13" @default.
• W4362665362 title "Garlic exosomes alleviate dextran sodium sulfate-induced colitis, in which peu-MIR2916-p3 acts as a key component boosting the growth of anti-colitis Bacteroides thetaiotaomicron" @default.
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• W4362665362 doi "https://doi.org/10.21203/rs.3.rs-2770180/v1" @default.
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