FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362667716> ?p ?o ?g. }

• W4362667716 endingPage "806" @default.
• W4362667716 startingPage "806" @default.
• W4362667716 abstract "SARS-CoV-2 vaccinations were initially shown to substantially reduce risk of severe disease and death. However, pharmacokinetic (PK) waning and rapid viral evolution degrade neutralizing antibody (nAb) binding titers, causing loss of vaccinal protection. Additionally, there is inter-individual heterogeneity in the strength and durability of the vaccinal nAb response. Here, we propose a personalized booster strategy as a potential solution to this problem. Our model-based approach incorporates inter-individual heterogeneity in nAb response to primary SARS-CoV-2 vaccination into a pharmacokinetic/pharmacodynamic (PK/PD) model to project population-level heterogeneity in vaccinal protection. We further examine the impact of evolutionary immune evasion on vaccinal protection over time based on variant fold reduction in nAb potency. Our findings suggest viral evolution will decrease the effectiveness of vaccinal protection against severe disease, especially for individuals with a less durable immune response. More frequent boosting may restore vaccinal protection for individuals with a weaker immune response. Our analysis shows that the ECLIA RBD binding assay strongly predicts neutralization of sequence-matched pseudoviruses. This may be a useful tool for rapidly assessing individual immune protection. Our work suggests vaccinal protection against severe disease is not assured and identifies a potential path forward for reducing risk to immunologically vulnerable individuals." @default.
• W4362667716 created "2023-04-07" @default.
• W4362667716 creator A5003610011 @default.
• W4362667716 creator A5007519678 @default.
• W4362667716 creator A5038829015 @default.
• W4362667716 creator A5045809200 @default.
• W4362667716 creator A5047844812 @default.
• W4362667716 creator A5054479296 @default.
• W4362667716 creator A5058738104 @default.
• W4362667716 creator A5073759779 @default.
• W4362667716 creator A5077516334 @default.
• W4362667716 creator A5089170432 @default.
• W4362667716 date "2023-04-06" @default.
• W4362667716 modified "2023-10-14" @default.
• W4362667716 title "Heterogeneity in Vaccinal Immunity to SARS-CoV-2 Can Be Addressed by a Personalized Booster Strategy" @default.
• W4362667716 cites W3025320502 @default.
• W4362667716 cites W3043431476 @default.
• W4362667716 cites W3043722389 @default.
• W4362667716 cites W3080581616 @default.
• W4362667716 cites W3089203609 @default.
• W4362667716 cites W3090717270 @default.
• W4362667716 cites W3096064145 @default.
• W4362667716 cites W3108610942 @default.
• W4362667716 cites W3109631032 @default.
• W4362667716 cites W3121008609 @default.
• W4362667716 cites W3123432125 @default.
• W4362667716 cites W3127852352 @default.
• W4362667716 cites W3157661219 @default.
• W4362667716 cites W3159116547 @default.
• W4362667716 cites W3159689317 @default.
• W4362667716 cites W3163785571 @default.
• W4362667716 cites W3165343550 @default.
• W4362667716 cites W3173651415 @default.
• W4362667716 cites W3174017401 @default.
• W4362667716 cites W3174517638 @default.
• W4362667716 cites W3176552995 @default.
• W4362667716 cites W3177772206 @default.
• W4362667716 cites W3189544042 @default.
• W4362667716 cites W3190606158 @default.
• W4362667716 cites W3193970141 @default.
• W4362667716 cites W3203490635 @default.
• W4362667716 cites W3204941174 @default.
• W4362667716 cites W3215494392 @default.
• W4362667716 cites W3217661335 @default.
• W4362667716 cites W4205483821 @default.
• W4362667716 cites W4207047906 @default.
• W4362667716 cites W4207080708 @default.
• W4362667716 cites W4210340210 @default.
• W4362667716 cites W4210664421 @default.
• W4362667716 cites W4210792795 @default.
• W4362667716 cites W4214483034 @default.
• W4362667716 cites W4214548857 @default.
• W4362667716 cites W4220667558 @default.
• W4362667716 cites W4220673385 @default.
• W4362667716 cites W4220836043 @default.
• W4362667716 cites W4221044276 @default.
• W4362667716 cites W4224268482 @default.
• W4362667716 cites W4225402540 @default.
• W4362667716 cites W4225470021 @default.
• W4362667716 cites W4225854071 @default.
• W4362667716 cites W4225982774 @default.
• W4362667716 cites W4226090490 @default.
• W4362667716 cites W4226155367 @default.
• W4362667716 cites W4229022258 @default.
• W4362667716 cites W4281253034 @default.
• W4362667716 cites W4281721420 @default.
• W4362667716 cites W4289767314 @default.
• W4362667716 cites W4317666074 @default.
• W4362667716 cites W4318462770 @default.
• W4362667716 doi "https://doi.org/10.3390/vaccines11040806" @default.
• W4362667716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37112718" @default.
• W4362667716 hasPublicationYear "2023" @default.
• W4362667716 type Work @default.
• W4362667716 citedByCount "1" @default.
• W4362667716 countsByYear W43626677162023 @default.
• W4362667716 crossrefType "journal-article" @default.
• W4362667716 hasAuthorship W4362667716A5003610011 @default.
• W4362667716 hasAuthorship W4362667716A5007519678 @default.
• W4362667716 hasAuthorship W4362667716A5038829015 @default.
• W4362667716 hasAuthorship W4362667716A5045809200 @default.
• W4362667716 hasAuthorship W4362667716A5047844812 @default.
• W4362667716 hasAuthorship W4362667716A5054479296 @default.
• W4362667716 hasAuthorship W4362667716A5058738104 @default.
• W4362667716 hasAuthorship W4362667716A5073759779 @default.
• W4362667716 hasAuthorship W4362667716A5077516334 @default.
• W4362667716 hasAuthorship W4362667716A5089170432 @default.
• W4362667716 hasBestOaLocation W43626677161 @default.
• W4362667716 hasConcept C121332964 @default.
• W4362667716 hasConcept C126322002 @default.
• W4362667716 hasConcept C1276947 @default.
• W4362667716 hasConcept C159047783 @default.
• W4362667716 hasConcept C159654299 @default.
• W4362667716 hasConcept C203014093 @default.
• W4362667716 hasConcept C203165030 @default.
• W4362667716 hasConcept C22070199 @default.
• W4362667716 hasConcept C2779134260 @default.
• W4362667716 hasConcept C2779341262 @default.
• W4362667716 hasConcept C2908647359 @default.

• next