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- W4362670384 abstract "Abstract N 6 -methyladenosine (m 6 A) modification has been shown to regulate RNA metabolism. Here, we investigate m 6 A dynamics during maternal-to-zygotic transition (MZT) in mice through multi-omic analysis. Our results show that m 6 A can be maternally inherited or de novo gained after fertilization. Interestingly, m 6 A modification on maternal mRNAs not only correlates with mRNA degradation, but also maintains the stability of a small group of mRNAs thereby promoting their translation after fertilization. We identify Ythdc1 and Ythdf2 as key m 6 A readers for mouse preimplantation development. Our study reveals a key role of m 6 A mediated RNA metabolism during MZT in mammals." @default.
- W4362670384 created "2023-04-07" @default.
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- W4362670384 date "2023-04-06" @default.
- W4362670384 modified "2023-10-18" @default.
- W4362670384 title "Reading and writing of mRNA m6A modification orchestrate maternal-to-zygotic transition in mice" @default.
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- W4362670384 doi "https://doi.org/10.1186/s13059-023-02918-9" @default.
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