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- W4362671323 endingPage "154442" @default.
- W4362671323 startingPage "154442" @default.
- W4362671323 abstract "Osteosarcoma (OS) is one of the most common bone cancers that constantly affects children, teenagers, and young adults. Numerous epigenetic elements, such as miRNAs, have been shown to influence OS features like progression, initiation, angiogenesis, and treatment resistance. The expression of numerous genes implicated in OS pathogenesis might be regulated by miRNAs. This effect is ascribed to miRNAs' roles in the invasion, angiogenesis, metastasis, proliferation, cell cycle, and apoptosis. Important OS-related mechanistic networks like the WNT/b-catenin signaling, PTEN/AKT/mTOR axis, and KRAS mutations are also affected by miRNAs. In addition to pathophysiology, miRNAs may influence how the OS reacts to therapies like radiotherapy and chemotherapy. With a focus on how miRNAs affect OS signaling pathways, this review seeks to show how miRNAs and OS are related." @default.
- W4362671323 created "2023-04-07" @default.
- W4362671323 creator A5021759842 @default.
- W4362671323 creator A5027390894 @default.
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- W4362671323 creator A5041373551 @default.
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- W4362671323 creator A5068467976 @default.
- W4362671323 creator A5075447277 @default.
- W4362671323 creator A5075906772 @default.
- W4362671323 date "2023-05-01" @default.
- W4362671323 modified "2023-10-16" @default.
- W4362671323 title "A spotlight on the interplay of signaling pathways and the role of miRNAs in osteosarcoma pathogenesis and therapeutic resistance" @default.
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