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- W4362671330 abstract "Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the epithelial cells of the nasopharynx with a unique geographic distribution, and is particularly prevalent in East and Southeast Asia. Due to its anatomical location, the surgery is difficult to access and the high sensitivity of nasopharyngeal cancer to radiotherapy (RT) makes it the main treatment modality. Radical radiotherapy is the first-line treatment for early-stage nasopharyngeal carcinoma and the cornerstone of multidisciplinary treatment for patients with locally advanced nasopharyngeal carcinoma. Nevertheless, radiotherapy interruption is inevitable as a consequence of unavoidable factors such as public holidays, machine malfunction, patient compliance, and adverse response to treatment, which in turn leads to a reduction in bioactivity and causes sublethal loss of tumor cells to repair. Unirradiated tumor cells are more likely to repopulate at or near their original fastest growth rate during this interval. If no measures are taken after the radiotherapy interruption, such as increasing the dose of radiotherapy and systemic therapy, the tumor is most likely to go uncontrolled and then progress. This review describes the effects of radiotherapy interruption on nasopharyngeal carcinoma, the mechanism of the effect, and explores the measures that can be taken in response to such interruption." @default.
- W4362671330 created "2023-04-07" @default.
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- W4362671330 creator A5037946278 @default.
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- W4362671330 date "2023-04-06" @default.
- W4362671330 modified "2023-09-26" @default.
- W4362671330 title "Effect of radiotherapy interruption on nasopharyngeal cancer" @default.
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- W4362671330 doi "https://doi.org/10.3389/fonc.2023.1114652" @default.
- W4362671330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37091186" @default.
- W4362671330 hasPublicationYear "2023" @default.
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