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• W4362692004 abstract "Environmental pollution may give rise to the incidence and progression of nonalcoholic fatty liver disease (NAFLD), the most common cause for chronic severe liver lesions. Although knowledge of NAFLD pathogenesis is particularly important for the development of effective prevention, the relationship between NAFLD occurrence and exposure to emerging pollutants, such as microplastics (MPs) and antibiotic residues, awaits assessment.This study aimed to evaluate the toxicity of MPs and antibiotic residues related to NAFLD occurrence using the zebrafish model species.Taking common polystyrene MPs and oxytetracycline (OTC) as representatives, typical NAFLD symptoms, including lipid accumulation, liver inflammation, and hepatic oxidative stress, were screened after 28-d exposure to environmentally realistic concentrations of MPs (0.69mg/L) and antibiotic residue (3.00μg/L). The impacts of MPs and OTC on gut health, the gut-liver axis, and hepatic lipid metabolism were also investigated to reveal potential affecting mechanisms underpinning the NAFLD symptoms observed.Compared with the control fish, zebrafish exposed to MPs and OTC exhibited significantly higher levels of lipid accumulation, triglycerides, and cholesterol contents, as well as inflammation, in conjunction with oxidative stress in their livers. In addition, a markedly smaller proportion of Proteobacteria and higher ratios of Firmicutes/Bacteroidetes were detected by microbiome analysis of gut contents in treated samples. After the exposures, the zebrafish also experienced intestinal oxidative injury and yielded significantly fewer numbers of goblet cells. Markedly higher levels of the intestinal bacteria-sourced endotoxin lipopolysaccharide (LPS) were also detected in serum. Animals treated with MPs and OTC exhibited higher expression levels of LPS binding receptor (LBP) and downstream inflammation-related genes while also exhibiting lower activity and gene expression of lipase. Furthermore, MP-OTC coexposure generally exerted more severe effects compared with single MP or OTC exposure.Our results suggested that exposure to MPs and OTC may disrupt the gut-liver axis and be associated with NAFLD occurrence. https://doi.org/10.1289/EHP11600." @default.
• W4362692004 created "2023-04-09" @default.
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• W4362692004 date "2023-04-01" @default.
• W4362692004 modified "2023-10-16" @default.
• W4362692004 title "Assessment of Nonalcoholic Fatty Liver Disease Symptoms and Gut–Liver Axis Status in Zebrafish after Exposure to Polystyrene Microplastics and Oxytetracycline, Alone and in Combination" @default.
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• W4362692004 cites W1506515851 @default.
• W4362692004 cites W1546226860 @default.
• W4362692004 cites W1585700338 @default.
• W4362692004 cites W1965359074 @default.
• W4362692004 cites W1972414743 @default.
• W4362692004 cites W1974033843 @default.
• W4362692004 cites W1988300130 @default.
• W4362692004 cites W2009417772 @default.
• W4362692004 cites W2019077752 @default.
• W4362692004 cites W2028448753 @default.
• W4362692004 cites W2036001279 @default.
• W4362692004 cites W2038961236 @default.
• W4362692004 cites W2044586254 @default.
• W4362692004 cites W2057965337 @default.
• W4362692004 cites W2059967908 @default.
• W4362692004 cites W2060906515 @default.
• W4362692004 cites W2062756785 @default.
• W4362692004 cites W2063832535 @default.
• W4362692004 cites W2080068601 @default.
• W4362692004 cites W2081361232 @default.
• W4362692004 cites W2086217680 @default.
• W4362692004 cites W2088833470 @default.
• W4362692004 cites W2095535649 @default.
• W4362692004 cites W2101964276 @default.
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• W4362692004 cites W2116961566 @default.
• W4362692004 cites W2119619598 @default.
• W4362692004 cites W2157507475 @default.
• W4362692004 cites W2160694733 @default.
• W4362692004 cites W2188751783 @default.
• W4362692004 cites W2192080449 @default.
• W4362692004 cites W2204688218 @default.
• W4362692004 cites W2212127474 @default.
• W4362692004 cites W2244276231 @default.
• W4362692004 cites W2288325680 @default.
• W4362692004 cites W2325301953 @default.
• W4362692004 cites W2419927501 @default.
• W4362692004 cites W2610516856 @default.
• W4362692004 cites W2621638375 @default.
• W4362692004 cites W2737217596 @default.
• W4362692004 cites W2744982526 @default.
• W4362692004 cites W2758788976 @default.
• W4362692004 cites W2766096406 @default.
• W4362692004 cites W2772777089 @default.
• W4362692004 cites W2772872384 @default.
• W4362692004 cites W2781500539 @default.
• W4362692004 cites W2789738056 @default.
• W4362692004 cites W2790965810 @default.
• W4362692004 cites W2791781902 @default.
• W4362692004 cites W2791897308 @default.
• W4362692004 cites W2795670227 @default.
• W4362692004 cites W2800792953 @default.
• W4362692004 cites W2803012718 @default.
• W4362692004 cites W2805380762 @default.
• W4362692004 cites W2885126584 @default.
• W4362692004 cites W2889932786 @default.
• W4362692004 cites W2892363894 @default.
• W4362692004 cites W2894492478 @default.
• W4362692004 cites W2905282109 @default.
• W4362692004 cites W2910341135 @default.
• W4362692004 cites W2914940150 @default.
• W4362692004 cites W2919483263 @default.
• W4362692004 cites W2928772646 @default.
• W4362692004 cites W2959032843 @default.
• W4362692004 cites W2972154950 @default.
• W4362692004 cites W2974748521 @default.
• W4362692004 cites W2980573871 @default.
• W4362692004 cites W2987473186 @default.
• W4362692004 cites W3012425114 @default.
• W4362692004 cites W3025485957 @default.
• W4362692004 cites W3026654791 @default.
• W4362692004 cites W3027118763 @default.
• W4362692004 cites W3027761339 @default.
• W4362692004 cites W3030897234 @default.
• W4362692004 cites W3034401490 @default.
• W4362692004 cites W3035597033 @default.
• W4362692004 cites W3041563536 @default.
• W4362692004 cites W3041686990 @default.

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