Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362692761> ?p ?o ?g. }
- W4362692761 endingPage "608" @default.
- W4362692761 startingPage "586" @default.
- W4362692761 abstract "Abstract Objective We used the lateral fluid percussion injury (LFPI) model of moderate‐to‐severe traumatic brain injury (TBI) to identify early plasma biomarkers predicting injury, early post‐traumatic seizures or neuromotor functional recovery (neuroscores), considering the effect of levetiracetam, which is commonly given after severe TBI. Methods Adult male Sprague–Dawley rats underwent left parietal LFPI, received levetiracetam (200 mg/kg bolus, 200 mg/kg/day subcutaneously for 7 days [7d]) or vehicle post‐LFPI, and were continuously video‐EEG recorded (n = 14/group). Sham (craniotomy only, n = 6), and naïve controls (n = 10) were also used. Neuroscores and plasma collection were done at 2d or 7d post‐LFPI or equivalent timepoints in sham/naïve. Plasma protein biomarker levels were determined by reverse phase protein microarray and classified according to injury severity (LFPI vs. sham/control), levetiracetam treatment, early seizures, and 2d‐to‐7d neuroscore recovery, using machine learning. Results Low 2d plasma levels of Thr 231 ‐phosphorylated tau protein (pTAU‐Thr 231 ) and S100B combined (ROC AUC = 0.7790) predicted prior craniotomy surgery ( diagnostic biomarker ). Levetiracetam‐treated LFPI rats were differentiated from vehicle treated by the 2d‐HMGB1, 2d‐pTAU‐Thr 231 , and 2d‐UCHL1 plasma levels combined (ROC AUC = 0.9394) ( pharmacodynamic biomarker ). Levetiracetam prevented the seizure effects on two biomarkers that predicted early seizures only among vehicle‐treated LFPI rats: pTAU‐Thr 231 (ROC AUC = 1) and UCHL1 (ROC AUC = 0.8333) ( prognostic biomarker of early seizures among vehicle‐treated LFPI rats ). Levetiracetam‐resistant early seizures were predicted by high 2d‐IFNγ plasma levels (ROC AUC = 0.8750) ( response biomarker ). 2d‐to‐7d neuroscore recovery was best predicted by higher 2d‐S100B, lower 2d‐HMGB1, and 2d‐to‐7d increase in HMGB1 or decrease in TNF ( P < 0.05) ( prognostic biomarkers ). Significance Antiseizure medications and early seizures need to be considered in the interpretation of early post‐traumatic biomarkers." @default.
- W4362692761 created "2023-04-09" @default.
- W4362692761 creator A5008663002 @default.
- W4362692761 creator A5010065799 @default.
- W4362692761 creator A5015013868 @default.
- W4362692761 creator A5026960157 @default.
- W4362692761 creator A5028315366 @default.
- W4362692761 creator A5028913352 @default.
- W4362692761 creator A5048618768 @default.
- W4362692761 creator A5061644716 @default.
- W4362692761 creator A5061872450 @default.
- W4362692761 creator A5063891394 @default.
- W4362692761 creator A5069803629 @default.
- W4362692761 creator A5070881534 @default.
- W4362692761 creator A5071037763 @default.
- W4362692761 creator A5073121947 @default.
- W4362692761 creator A5074490267 @default.
- W4362692761 creator A5075246322 @default.
- W4362692761 creator A5078165559 @default.
- W4362692761 creator A5078803107 @default.
- W4362692761 creator A5080385365 @default.
- W4362692761 date "2023-04-25" @default.
- W4362692761 modified "2023-10-14" @default.
- W4362692761 title "Early preclinical plasma protein biomarkers of brain trauma are influenced by early seizures and levetiracetam" @default.
- W4362692761 cites W145505251 @default.
- W4362692761 cites W1488400941 @default.
- W4362692761 cites W1534865669 @default.
- W4362692761 cites W1831816201 @default.
- W4362692761 cites W1968657909 @default.
- W4362692761 cites W1982466286 @default.
- W4362692761 cites W1983635597 @default.
- W4362692761 cites W198953883 @default.
- W4362692761 cites W1989811470 @default.
- W4362692761 cites W1992330541 @default.
- W4362692761 cites W1994325823 @default.
- W4362692761 cites W1997992092 @default.
- W4362692761 cites W2005728257 @default.
- W4362692761 cites W2006929972 @default.
- W4362692761 cites W2007191899 @default.
- W4362692761 cites W2010247798 @default.
- W4362692761 cites W2012763966 @default.
- W4362692761 cites W2031517843 @default.
- W4362692761 cites W2033872429 @default.
- W4362692761 cites W2035506759 @default.
- W4362692761 cites W2036088133 @default.
- W4362692761 cites W2051381147 @default.
- W4362692761 cites W2051600991 @default.
- W4362692761 cites W2058035812 @default.
- W4362692761 cites W2060587811 @default.
- W4362692761 cites W2068145211 @default.
- W4362692761 cites W2073215785 @default.
- W4362692761 cites W2081678164 @default.
- W4362692761 cites W2085509762 @default.
- W4362692761 cites W2085809531 @default.
- W4362692761 cites W2089114049 @default.
- W4362692761 cites W2089943045 @default.
- W4362692761 cites W2090339105 @default.
- W4362692761 cites W2095415351 @default.
- W4362692761 cites W2097787145 @default.
- W4362692761 cites W2107736622 @default.
- W4362692761 cites W2113615687 @default.
- W4362692761 cites W2117656083 @default.
- W4362692761 cites W2139885710 @default.
- W4362692761 cites W2150857727 @default.
- W4362692761 cites W2150941374 @default.
- W4362692761 cites W2195245412 @default.
- W4362692761 cites W2298601289 @default.
- W4362692761 cites W2325514422 @default.
- W4362692761 cites W2401450306 @default.
- W4362692761 cites W2412978786 @default.
- W4362692761 cites W2433196212 @default.
- W4362692761 cites W2442333327 @default.
- W4362692761 cites W2461647519 @default.
- W4362692761 cites W2477083732 @default.
- W4362692761 cites W2524473181 @default.
- W4362692761 cites W2530536753 @default.
- W4362692761 cites W2588084589 @default.
- W4362692761 cites W2606398663 @default.
- W4362692761 cites W2619641984 @default.
- W4362692761 cites W2736002996 @default.
- W4362692761 cites W2738010656 @default.
- W4362692761 cites W2767335159 @default.
- W4362692761 cites W2792801585 @default.
- W4362692761 cites W2800035737 @default.
- W4362692761 cites W2802023214 @default.
- W4362692761 cites W2805677861 @default.
- W4362692761 cites W2808596369 @default.
- W4362692761 cites W2809362554 @default.
- W4362692761 cites W2848717028 @default.
- W4362692761 cites W2883056698 @default.
- W4362692761 cites W2883751442 @default.
- W4362692761 cites W2884297803 @default.
- W4362692761 cites W2891402596 @default.
- W4362692761 cites W2897052794 @default.
- W4362692761 cites W2899240074 @default.
- W4362692761 cites W2901147389 @default.
- W4362692761 cites W2902315624 @default.
- W4362692761 cites W2902723466 @default.