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- W4362695413 endingPage "114673" @default.
- W4362695413 startingPage "114673" @default.
- W4362695413 abstract "Potassium channels play an important role in human physiological function. Recently, various molecular mechanisms have implicated abnormal functioning of potassium channels in the proliferation, migration, invasion, apoptosis, and cancer stem cell phenotype formation. Potassium channels also mediate the association of tumor cells with the tumor microenvironment. Meanwhile, potassium channels are important targets for cancer chemotherapy. A variety of drugs exert anti-cancer effects by modulating potassium channels in tumor cells. Therefore, there is a need to understand how potassium channels participate in tumor development and progression, which could reveal new, novel targets for cancer diagnosis and treatment. This review summarizes the roles of voltage-gated potassium channels, calcium-activated potassium channels, inwardly rectifying potassium channels, and two-pore domain potassium channels in tumorigenesis and the underlying mechanism of potassium channel-targeted drugs. Therefore, the study lays the foundation for rational and effective drug design and individualized clinical therapeutics." @default.
- W4362695413 created "2023-04-09" @default.
- W4362695413 creator A5005814364 @default.
- W4362695413 creator A5062468779 @default.
- W4362695413 creator A5062730028 @default.
- W4362695413 creator A5063442011 @default.
- W4362695413 creator A5081165104 @default.
- W4362695413 creator A5082084048 @default.
- W4362695413 date "2023-06-01" @default.
- W4362695413 modified "2023-10-15" @default.
- W4362695413 title "Potassium channels, tumorigenesis and targeted drugs" @default.
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