FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362698560> ?p ?o ?g. }

• W4362698560 abstract "Epidemiological evidence relating sleep disorders to end-stage renal disease (ESRD) has been obscure. The present study is sought to examine the association between sleep traits and ESRD.For this analysis, we selected genetic instruments for sleep traits from published genome-wide association studies (GWAS). As instrumental variables, independent genetic variations linked with seven sleep-related features (sleep duration, getting up in the morning, daytime napping, chronotype of morning/evening person, sleeplessness/insomnia, non-snoring, and daytime dozing) were chosen. A two-sample Mendelian randomization (TSMR) study was conducted to assess the causal relationship between sleep traits and ESRD (N = 33,061). The reverse MR analysis subsequently determined the causal relationship between ESRD and sleep traits. The causal effects were estimated using inverse variance weighted, MR-Egger, weighted median. To conduct sensitivity studies, Cochran's Q test, MR-Egger intercept test, MR-PRESSO, leave-one-out analysis, and funnel plot were used. To study the potential mediators, multivariable mendelian randomization analyses were undertaken further.Genetically predicted sleeplessness/ insomnia (OR = 6.11, 95%CI 1.00-37.3, P = 0.049, FDR = 0.105), getting up in the morning easily(OR = 0.23, 95%CI 0.063-0.85; P = 0.0278, FDR = 0.105), non-snoring (OR = 4.76E-02, 95%CI 2.29E-03-0.985, P = 0.0488, FDR = 0.105) was suggestively associated with the risk of ESRD. However, we found no evidence favoring a causal association between other sleep traits and ESRD through the IVW method.The present TSMR found no strong evidence of a bidirectional causal association between genetically predicted sleep traits and ESRD." @default.
• W4362698560 created "2023-04-09" @default.
• W4362698560 creator A5002536493 @default.
• W4362698560 creator A5054230348 @default.
• W4362698560 creator A5057964648 @default.
• W4362698560 creator A5060506125 @default.
• W4362698560 date "2023-04-07" @default.
• W4362698560 modified "2023-10-01" @default.
• W4362698560 title "Sleep traits and risk of end-stage renal disease: a mendelian randomization study" @default.
• W4362698560 cites W1491124385 @default.
• W4362698560 cites W1902575419 @default.
• W4362698560 cites W1977631420 @default.
• W4362698560 cites W1980593983 @default.
• W4362698560 cites W1987178383 @default.
• W4362698560 cites W2003916569 @default.
• W4362698560 cites W2034487881 @default.
• W4362698560 cites W2088309211 @default.
• W4362698560 cites W2103783427 @default.
• W4362698560 cites W2113699335 @default.
• W4362698560 cites W2120581740 @default.
• W4362698560 cites W2164249826 @default.
• W4362698560 cites W2403553291 @default.
• W4362698560 cites W2411709723 @default.
• W4362698560 cites W2488615655 @default.
• W4362698560 cites W2562743437 @default.
• W4362698560 cites W2582094868 @default.
• W4362698560 cites W2616479582 @default.
• W4362698560 cites W2617357508 @default.
• W4362698560 cites W2803072880 @default.
• W4362698560 cites W2805983714 @default.
• W4362698560 cites W2883622734 @default.
• W4362698560 cites W2898290404 @default.
• W4362698560 cites W2899470117 @default.
• W4362698560 cites W2901499556 @default.
• W4362698560 cites W2922189800 @default.
• W4362698560 cites W2952013316 @default.
• W4362698560 cites W2969924378 @default.
• W4362698560 cites W2995235638 @default.
• W4362698560 cites W3013759062 @default.
• W4362698560 cites W3020059669 @default.
• W4362698560 cites W3027125941 @default.
• W4362698560 cites W3048245060 @default.
• W4362698560 cites W3095360514 @default.
• W4362698560 cites W3118652808 @default.
• W4362698560 cites W3175145970 @default.
• W4362698560 cites W3195227361 @default.
• W4362698560 cites W3195762401 @default.
• W4362698560 cites W3204669952 @default.
• W4362698560 cites W3206577920 @default.
• W4362698560 cites W3209474273 @default.
• W4362698560 cites W3210570897 @default.
• W4362698560 cites W4210640660 @default.
• W4362698560 cites W4220802540 @default.
• W4362698560 cites W4221121147 @default.
• W4362698560 cites W4225378800 @default.
• W4362698560 cites W4225658861 @default.
• W4362698560 cites W4282937974 @default.
• W4362698560 cites W4285719527 @default.
• W4362698560 cites W4286559989 @default.
• W4362698560 cites W4288059218 @default.
• W4362698560 cites W762533598 @default.
• W4362698560 doi "https://doi.org/10.1186/s12920-023-01497-9" @default.
• W4362698560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37029366" @default.
• W4362698560 hasPublicationYear "2023" @default.
• W4362698560 type Work @default.
• W4362698560 citedByCount "0" @default.
• W4362698560 crossrefType "journal-article" @default.
• W4362698560 hasAuthorship W4362698560A5002536493 @default.
• W4362698560 hasAuthorship W4362698560A5054230348 @default.
• W4362698560 hasAuthorship W4362698560A5057964648 @default.
• W4362698560 hasAuthorship W4362698560A5060506125 @default.
• W4362698560 hasBestOaLocation W43626985601 @default.
• W4362698560 hasConcept C104317684 @default.
• W4362698560 hasConcept C106208931 @default.
• W4362698560 hasConcept C126322002 @default.
• W4362698560 hasConcept C135763542 @default.
• W4362698560 hasConcept C143998085 @default.
• W4362698560 hasConcept C153209595 @default.
• W4362698560 hasConcept C19720800 @default.
• W4362698560 hasConcept C2778205975 @default.
• W4362698560 hasConcept C2779901538 @default.
• W4362698560 hasConcept C2780439572 @default.
• W4362698560 hasConcept C2781326671 @default.
• W4362698560 hasConcept C2993967602 @default.
• W4362698560 hasConcept C47056694 @default.
• W4362698560 hasConcept C54355233 @default.
• W4362698560 hasConcept C71924100 @default.
• W4362698560 hasConcept C82605166 @default.
• W4362698560 hasConcept C86803240 @default.
• W4362698560 hasConcept C95190672 @default.
• W4362698560 hasConceptScore W4362698560C104317684 @default.
• W4362698560 hasConceptScore W4362698560C106208931 @default.
• W4362698560 hasConceptScore W4362698560C126322002 @default.
• W4362698560 hasConceptScore W4362698560C135763542 @default.
• W4362698560 hasConceptScore W4362698560C143998085 @default.
• W4362698560 hasConceptScore W4362698560C153209595 @default.
• W4362698560 hasConceptScore W4362698560C19720800 @default.
• W4362698560 hasConceptScore W4362698560C2778205975 @default.
• W4362698560 hasConceptScore W4362698560C2779901538 @default.
• W4362698560 hasConceptScore W4362698560C2780439572 @default.

• next