Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362698573> ?p ?o ?g. }
- W4362698573 abstract "The sympathetic nervous system is crucial for controlling multiple cardiac functions. However, a comprehensive, detailed neuroanatomical map of the sympathetic innervation of the heart is unavailable. Here, we used a combination of state-of-the-art techniques, including flat-mount tissue processing, immunohistochemistry for tyrosine hydroxylase (TH, a sympathetic marker), confocal microscopy and Neurolucida 360 software to trace, digitize, and quantitatively map the topographical distribution of the sympathetic postganglionic innervation in whole atria of C57Bl/6 J mice. We found that (1) 4-5 major extrinsic TH-IR nerve bundles entered the atria at the superior vena cava, right atrium (RA), left precaval vein and the root of the pulmonary veins (PVs) in the left atrium (LA). Although these bundles projected to different areas of the atria, their projection fields partially overlapped. (2) TH-IR axon and terminal density varied considerably between different sites of the atria with the greatest density of innervation near the sinoatrial node region (P < 0.05, n = 6). (3) TH-IR axons also innervated blood vessels and adipocytes. (4) Many principal neurons in intrinsic cardiac ganglia and small intensely fluorescent cells were also strongly TH-IR. Our work provides a comprehensive topographical map of the catecholaminergic efferent axon morphology, innervation, and distribution in the whole atria at single cell/axon/varicosity scale that may be used in future studies to create a cardiac sympathetic-brain atlas." @default.
- W4362698573 created "2023-04-09" @default.
- W4362698573 creator A5002188808 @default.
- W4362698573 creator A5008488759 @default.
- W4362698573 creator A5015199163 @default.
- W4362698573 creator A5017179542 @default.
- W4362698573 creator A5018480198 @default.
- W4362698573 creator A5028348554 @default.
- W4362698573 creator A5055228603 @default.
- W4362698573 creator A5061957757 @default.
- W4362698573 creator A5062469678 @default.
- W4362698573 creator A5079128494 @default.
- W4362698573 creator A5087333350 @default.
- W4362698573 date "2023-04-07" @default.
- W4362698573 modified "2023-09-30" @default.
- W4362698573 title "Topographical mapping of catecholaminergic axon innervation in the flat-mounts of the mouse atria: a quantitative analysis" @default.
- W4362698573 cites W1932433776 @default.
- W4362698573 cites W1964260374 @default.
- W4362698573 cites W1966193155 @default.
- W4362698573 cites W1966391747 @default.
- W4362698573 cites W1968959522 @default.
- W4362698573 cites W1970904953 @default.
- W4362698573 cites W1972225938 @default.
- W4362698573 cites W1978377233 @default.
- W4362698573 cites W1978499715 @default.
- W4362698573 cites W1979908130 @default.
- W4362698573 cites W1980537775 @default.
- W4362698573 cites W1984549300 @default.
- W4362698573 cites W1987735654 @default.
- W4362698573 cites W1990112639 @default.
- W4362698573 cites W1991077450 @default.
- W4362698573 cites W1991845771 @default.
- W4362698573 cites W1992013109 @default.
- W4362698573 cites W2000383003 @default.
- W4362698573 cites W2005970828 @default.
- W4362698573 cites W2012256652 @default.
- W4362698573 cites W2017645033 @default.
- W4362698573 cites W2019709839 @default.
- W4362698573 cites W2021059534 @default.
- W4362698573 cites W2033152716 @default.
- W4362698573 cites W2034798701 @default.
- W4362698573 cites W2035541558 @default.
- W4362698573 cites W2035924854 @default.
- W4362698573 cites W2035960292 @default.
- W4362698573 cites W2041656171 @default.
- W4362698573 cites W2043332412 @default.
- W4362698573 cites W2045101954 @default.
- W4362698573 cites W2062413904 @default.
- W4362698573 cites W2065323488 @default.
- W4362698573 cites W2072325180 @default.
- W4362698573 cites W2072437529 @default.
- W4362698573 cites W2085621500 @default.
- W4362698573 cites W2090993811 @default.
- W4362698573 cites W2099991168 @default.
- W4362698573 cites W2101271809 @default.
- W4362698573 cites W2103029322 @default.
- W4362698573 cites W2117438002 @default.
- W4362698573 cites W2119085011 @default.
- W4362698573 cites W2122365943 @default.
- W4362698573 cites W2123443198 @default.
- W4362698573 cites W2123966839 @default.
- W4362698573 cites W2133794920 @default.
- W4362698573 cites W2139407736 @default.
- W4362698573 cites W2142434622 @default.
- W4362698573 cites W2143898056 @default.
- W4362698573 cites W2149264972 @default.
- W4362698573 cites W2154225726 @default.
- W4362698573 cites W2155458325 @default.
- W4362698573 cites W2167279371 @default.
- W4362698573 cites W2169873170 @default.
- W4362698573 cites W2332171025 @default.
- W4362698573 cites W2344634374 @default.
- W4362698573 cites W2397449051 @default.
- W4362698573 cites W2490192389 @default.
- W4362698573 cites W2515065358 @default.
- W4362698573 cites W2548275652 @default.
- W4362698573 cites W2592877900 @default.
- W4362698573 cites W2621863408 @default.
- W4362698573 cites W2782888263 @default.
- W4362698573 cites W2797970335 @default.
- W4362698573 cites W2806825566 @default.
- W4362698573 cites W2898558190 @default.
- W4362698573 cites W2912187960 @default.
- W4362698573 cites W2945743937 @default.
- W4362698573 cites W294850814 @default.
- W4362698573 cites W3047306010 @default.
- W4362698573 cites W3109721048 @default.
- W4362698573 cites W3131160888 @default.
- W4362698573 cites W3153091087 @default.
- W4362698573 cites W3201083203 @default.
- W4362698573 cites W3211133494 @default.
- W4362698573 cites W3215468355 @default.
- W4362698573 cites W4212879942 @default.
- W4362698573 cites W4220839663 @default.
- W4362698573 cites W4252039959 @default.
- W4362698573 cites W4313453672 @default.
- W4362698573 cites W4317616044 @default.
- W4362698573 doi "https://doi.org/10.1038/s41598-023-27727-9" @default.
- W4362698573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37029119" @default.
- W4362698573 hasPublicationYear "2023" @default.