Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362706462> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4362706462 abstract "Millions of people worldwide deal with issues concerning fertility. Reduced fertility, or even infertility, may be due to many different causes, including genetic disorders, of which chromosomal abnormalities are the most common. Fluorescence in situ hybridization (FISH) is a well-known and frequently used method to detect chromosomal aberrations in humans. FISH is mainly used for the analysis of chromosomal abnormalities in the spermatozoa of males with numerical or structural chromosomal aberrations. Furthermore, this technique is also frequently applied in females to detect X chromosomal aberrations that are known to cause ovarian dysgenesis. However, information on the X chromosomal content of ovarian cells from females with X chromosomal aberrations in lymphocytes and/or buccal cells is still lacking. The aim of this study is to advance basic research regarding X chromosomal aberrations in females, by presenting two methods based on FISH to identify the X chromosomal content of ovarian cells. First, a method is described to determine the X chromosomal content of isolated ovarian cells (oocytes, granulosa cells, and stromal cells) in non-grafted ovarian cortex tissue from females with X chromosomal aberrations. The second method is directed at evaluating the effect of chromosomal aberrations on folliculogenesis by determining the X chromosomal content of ovarian cells of newly formed secondary and antral follicles in ovarian tissue, from females with X chromosomal aberrations after long-term grafting into immunocompromised mice. Both methods could be helpful in future research to gain insight into the reproductive potential of females with X chromosomal aberrations." @default.
- W4362706462 created "2023-04-09" @default.
- W4362706462 creator A5010740515 @default.
- W4362706462 creator A5049939791 @default.
- W4362706462 creator A5068134792 @default.
- W4362706462 creator A5073397763 @default.
- W4362706462 creator A5081202942 @default.
- W4362706462 date "2023-04-07" @default.
- W4362706462 modified "2023-09-27" @default.
- W4362706462 title "Exploring X Chromosomal Aberrations in Ovarian Cells by using Fluorescence <em>In Situ</em> Hybridization" @default.
- W4362706462 doi "https://doi.org/10.3791/64734" @default.
- W4362706462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37092819" @default.
- W4362706462 hasPublicationYear "2023" @default.
- W4362706462 type Work @default.
- W4362706462 citedByCount "0" @default.
- W4362706462 crossrefType "journal-article" @default.
- W4362706462 hasAuthorship W4362706462A5010740515 @default.
- W4362706462 hasAuthorship W4362706462A5049939791 @default.
- W4362706462 hasAuthorship W4362706462A5068134792 @default.
- W4362706462 hasAuthorship W4362706462A5073397763 @default.
- W4362706462 hasAuthorship W4362706462A5081202942 @default.
- W4362706462 hasConcept C104317684 @default.
- W4362706462 hasConcept C124942203 @default.
- W4362706462 hasConcept C16685009 @default.
- W4362706462 hasConcept C167871757 @default.
- W4362706462 hasConcept C179933525 @default.
- W4362706462 hasConcept C196843134 @default.
- W4362706462 hasConcept C2777542201 @default.
- W4362706462 hasConcept C2910535243 @default.
- W4362706462 hasConcept C30481170 @default.
- W4362706462 hasConcept C53226629 @default.
- W4362706462 hasConcept C54355233 @default.
- W4362706462 hasConcept C5512455 @default.
- W4362706462 hasConcept C71924100 @default.
- W4362706462 hasConcept C86546924 @default.
- W4362706462 hasConcept C86803240 @default.
- W4362706462 hasConceptScore W4362706462C104317684 @default.
- W4362706462 hasConceptScore W4362706462C124942203 @default.
- W4362706462 hasConceptScore W4362706462C16685009 @default.
- W4362706462 hasConceptScore W4362706462C167871757 @default.
- W4362706462 hasConceptScore W4362706462C179933525 @default.
- W4362706462 hasConceptScore W4362706462C196843134 @default.
- W4362706462 hasConceptScore W4362706462C2777542201 @default.
- W4362706462 hasConceptScore W4362706462C2910535243 @default.
- W4362706462 hasConceptScore W4362706462C30481170 @default.
- W4362706462 hasConceptScore W4362706462C53226629 @default.
- W4362706462 hasConceptScore W4362706462C54355233 @default.
- W4362706462 hasConceptScore W4362706462C5512455 @default.
- W4362706462 hasConceptScore W4362706462C71924100 @default.
- W4362706462 hasConceptScore W4362706462C86546924 @default.
- W4362706462 hasConceptScore W4362706462C86803240 @default.
- W4362706462 hasIssue "194" @default.
- W4362706462 hasLocation W43627064621 @default.
- W4362706462 hasLocation W43627064622 @default.
- W4362706462 hasOpenAccess W4362706462 @default.
- W4362706462 hasPrimaryLocation W43627064621 @default.
- W4362706462 hasRelatedWork W1967471735 @default.
- W4362706462 hasRelatedWork W2027559078 @default.
- W4362706462 hasRelatedWork W2047750426 @default.
- W4362706462 hasRelatedWork W2078036860 @default.
- W4362706462 hasRelatedWork W2132288466 @default.
- W4362706462 hasRelatedWork W271357513 @default.
- W4362706462 hasRelatedWork W3024821140 @default.
- W4362706462 hasRelatedWork W3143022516 @default.
- W4362706462 hasRelatedWork W4360803675 @default.
- W4362706462 hasRelatedWork W4362706462 @default.
- W4362706462 isParatext "false" @default.
- W4362706462 isRetracted "false" @default.
- W4362706462 workType "article" @default.