FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362720753> ?p ?o ?g. }

• W4362720753 abstract "To evaluate the impact of bone marrow (BM) irradiation dose on acute haematologic toxicity (HT) in concurrent chemoradiotherapy for cervical cancer.Sixty-nine patients with cervical cancer treated with curative or postoperative adjuvant therapy received weekly cisplatin concurrent chemotherapy (CCT) and intensity-modulated radiation therapy (IMRT). The whole pelvic bone marrow (PBM) was delineated and divided into three subsites: ilium (IL), lower pelvis (LP), and lumbosacral spine (LS). Associations between clinical variables, dose volume of BM, including PBM, IL, LP, and LS in the form of x-Vy (volume receiving y Gy for x), and blood cell count nadir were tested using linear regression models. Receiver operating characteristic (ROC) curve analysis was further used to analyse the cutoff values of the variables with p < 0.05 in the multivariate analysis.In 69 patients, the haemoglobin nadir was positive correlated with baseline haemoglobin (p < 0.001), negative correlated with relative LP-V10 (p = 0.005), relative LP-V25 (p = 0.002), relative LP-V50 (p = 0.007), relative LP-mean (p = 0.003), absolute LP-V15 (p = 0.049), absolute LP-V25 (p = 0.004) and absolute LP-V30 (p = 0.009). The platelet nadir was positive correlated with baseline platelets (p = 0.048) and negative correlated with relative LP-V40 (p = 0.028), but there was no significant variable in absolute radiation volume by multivariate analysis. No variables related to the neutrophil nadir were found, and the 69 patients were divided into group A (43 cases) receiving 3-4 cycles of CCT and group B (26 cases) receiving 5-6 cycles of CCT. In group A, the relative IL-V15 (p = 0.014), the relative IL-V50 (p = 0.010) and the absolute LP-V50 (p = 0.011) were negative correlated with the neutrophil nadir. No significant variable was found in group B. No significant variables related to the lymphocyte nadir were found, and the neutrophil-to-lymphocyte ratio (NLR) was analysed. Age (p < 0.05), relative LP-V15 (p = 0.037) and absolute PBM-mean (p < 0.001) were found to be negative related to NLR.The dosimetric parameters of relative irradiated volume of BM have more statistically significant datas on acute HT than absolute irradiated volume. The nadir of haemoglobin and platelets and the vertice of NLR were more affected by the irradiation dose to LP, while neutrophils were more affected by the dose to IL. Acute HT was negative related to both low-dose irradiation (V10-30) and high-dose irradiation (V40, V50). For more than 4 cycles of CCT, the effect of BM irradiation on the neutrophils nadir was masked by chemotherapy." @default.
• W4362720753 created "2023-04-09" @default.
• W4362720753 creator A5005694721 @default.
• W4362720753 creator A5009360475 @default.
• W4362720753 creator A5012718640 @default.
• W4362720753 creator A5015743711 @default.
• W4362720753 creator A5023168022 @default.
• W4362720753 creator A5023605076 @default.
• W4362720753 creator A5043651524 @default.
• W4362720753 creator A5050227440 @default.
• W4362720753 creator A5058848982 @default.
• W4362720753 creator A5058963598 @default.
• W4362720753 creator A5080065288 @default.
• W4362720753 date "2023-04-08" @default.
• W4362720753 modified "2023-09-26" @default.
• W4362720753 title "The impact of bone marrow irradiation dose on acute haematologic toxicity in cervical cancer patients treated with concurrent chemoradiotherapy" @default.
• W4362720753 cites W1773441184 @default.
• W4362720753 cites W1966853096 @default.
• W4362720753 cites W1977336247 @default.
• W4362720753 cites W1990828990 @default.
• W4362720753 cites W2002225209 @default.
• W4362720753 cites W2018650910 @default.
• W4362720753 cites W2043945205 @default.
• W4362720753 cites W2047348005 @default.
• W4362720753 cites W2062941526 @default.
• W4362720753 cites W2068830075 @default.
• W4362720753 cites W2087031244 @default.
• W4362720753 cites W2094087519 @default.
• W4362720753 cites W2162599634 @default.
• W4362720753 cites W2164891366 @default.
• W4362720753 cites W2537867879 @default.
• W4362720753 cites W2549654280 @default.
• W4362720753 cites W2766180335 @default.
• W4362720753 cites W2940096357 @default.
• W4362720753 cites W2966776826 @default.
• W4362720753 cites W3212504806 @default.
• W4362720753 cites W4226344535 @default.
• W4362720753 cites W4285294770 @default.
• W4362720753 cites W4306755655 @default.
• W4362720753 doi "https://doi.org/10.1186/s13014-023-02248-x" @default.
• W4362720753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37031167" @default.
• W4362720753 hasPublicationYear "2023" @default.
• W4362720753 type Work @default.
• W4362720753 citedByCount "0" @default.
• W4362720753 crossrefType "journal-article" @default.
• W4362720753 hasAuthorship W4362720753A5005694721 @default.
• W4362720753 hasAuthorship W4362720753A5009360475 @default.
• W4362720753 hasAuthorship W4362720753A5012718640 @default.
• W4362720753 hasAuthorship W4362720753A5015743711 @default.
• W4362720753 hasAuthorship W4362720753A5023168022 @default.
• W4362720753 hasAuthorship W4362720753A5023605076 @default.
• W4362720753 hasAuthorship W4362720753A5043651524 @default.
• W4362720753 hasAuthorship W4362720753A5050227440 @default.
• W4362720753 hasAuthorship W4362720753A5058848982 @default.
• W4362720753 hasAuthorship W4362720753A5058963598 @default.
• W4362720753 hasAuthorship W4362720753A5080065288 @default.
• W4362720753 hasBestOaLocation W43627207531 @default.
• W4362720753 hasConcept C121608353 @default.
• W4362720753 hasConcept C126322002 @default.
• W4362720753 hasConcept C126894567 @default.
• W4362720753 hasConcept C141071460 @default.
• W4362720753 hasConcept C143998085 @default.
• W4362720753 hasConcept C2776581026 @default.
• W4362720753 hasConcept C2778220009 @default.
• W4362720753 hasConcept C2778424827 @default.
• W4362720753 hasConcept C2780007613 @default.
• W4362720753 hasConcept C29730261 @default.
• W4362720753 hasConcept C2989005 @default.
• W4362720753 hasConcept C509974204 @default.
• W4362720753 hasConcept C71924100 @default.
• W4362720753 hasConcept C90924648 @default.
• W4362720753 hasConceptScore W4362720753C121608353 @default.
• W4362720753 hasConceptScore W4362720753C126322002 @default.
• W4362720753 hasConceptScore W4362720753C126894567 @default.
• W4362720753 hasConceptScore W4362720753C141071460 @default.
• W4362720753 hasConceptScore W4362720753C143998085 @default.
• W4362720753 hasConceptScore W4362720753C2776581026 @default.
• W4362720753 hasConceptScore W4362720753C2778220009 @default.
• W4362720753 hasConceptScore W4362720753C2778424827 @default.
• W4362720753 hasConceptScore W4362720753C2780007613 @default.
• W4362720753 hasConceptScore W4362720753C29730261 @default.
• W4362720753 hasConceptScore W4362720753C2989005 @default.
• W4362720753 hasConceptScore W4362720753C509974204 @default.
• W4362720753 hasConceptScore W4362720753C71924100 @default.
• W4362720753 hasConceptScore W4362720753C90924648 @default.
• W4362720753 hasIssue "1" @default.
• W4362720753 hasLocation W43627207531 @default.
• W4362720753 hasLocation W43627207532 @default.
• W4362720753 hasLocation W43627207533 @default.
• W4362720753 hasOpenAccess W4362720753 @default.
• W4362720753 hasPrimaryLocation W43627207531 @default.
• W4362720753 hasRelatedWork W1490390872 @default.
• W4362720753 hasRelatedWork W1995788949 @default.
• W4362720753 hasRelatedWork W2376116016 @default.
• W4362720753 hasRelatedWork W2384708512 @default.
• W4362720753 hasRelatedWork W2394357887 @default.
• W4362720753 hasRelatedWork W3030063216 @default.
• W4362720753 hasRelatedWork W3030242172 @default.
• W4362720753 hasRelatedWork W4245694863 @default.
• W4362720753 hasRelatedWork W4385733218 @default.

• next