FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362720865> ?p ?o ?g. }

• W4362720865 endingPage "137" @default.
• W4362720865 startingPage "127" @default.
• W4362720865 abstract "Peripheral injury during the early postnatal period alters the somatosensory system, leading to behavioural hyperalgesia upon re-injury in adulthood. Spinal microglia have been implicated as the cellular mediators of this phenomenon, but the mechanism is unclear. We hypothesised that neonatal injury (1) alters microglial phagocytosis of synapses in the dorsal horn leading to long-term structural changes in neurons, and/or (2) trains microglia, leading to a stronger microglial response after re-injury in adulthood. Using hindpaw surgical incision as a model we showed that microglial density and phagocytosis increased in the dorsal horn region innervated by the hindpaw. Dorsal horn microglia increased engulfment of synapses following injury, with a preference for those expressing the vesicular GABA transporter VGAT and primary afferent A-fibre terminals in neonates. This led to a long-term reduction of VGAT density in the dorsal horn and reduced microglial phagocytosis of VGLUT2 terminals. We also saw an increase in apoptosis following neonatal injury, which was not limited to the dorsal horn suggesting that larger circuit wide changes are happening. In adults, hindpaw incision increased microglial engulfment of predominantly VGAT synapses but did not alter the engulfment of A-fibres. This engulfment was not affected by prior neonatal injury, suggesting that microglial phagocytosis was not trained. These results highlight microglial phagocytosis in the dorsal horn as an important physiological response towards peripheral injury with potential long-term consequences and reveals differences in microglial responses between neonates and adults." @default.
• W4362720865 created "2023-04-09" @default.
• W4362720865 creator A5010466843 @default.
• W4362720865 creator A5049481404 @default.
• W4362720865 creator A5072782296 @default.
• W4362720865 creator A5080036092 @default.
• W4362720865 date "2023-07-01" @default.
• W4362720865 modified "2023-10-18" @default.
• W4362720865 title "Microglial phagocytosis mediates long-term restructuring of spinal GABAergic circuits following early life injury" @default.
• W4362720865 cites W1456373634 @default.
• W4362720865 cites W1567615855 @default.
• W4362720865 cites W1679166795 @default.
• W4362720865 cites W1945096581 @default.
• W4362720865 cites W1964041350 @default.
• W4362720865 cites W1968422624 @default.
• W4362720865 cites W1977222339 @default.
• W4362720865 cites W1980789245 @default.
• W4362720865 cites W1981546597 @default.
• W4362720865 cites W2008757142 @default.
• W4362720865 cites W2016321438 @default.
• W4362720865 cites W2018425003 @default.
• W4362720865 cites W2019056620 @default.
• W4362720865 cites W2028521977 @default.
• W4362720865 cites W2031502025 @default.
• W4362720865 cites W2033617297 @default.
• W4362720865 cites W2034709588 @default.
• W4362720865 cites W2034953779 @default.
• W4362720865 cites W2036804461 @default.
• W4362720865 cites W2039563461 @default.
• W4362720865 cites W2053924743 @default.
• W4362720865 cites W2060316458 @default.
• W4362720865 cites W2063223361 @default.
• W4362720865 cites W2066943555 @default.
• W4362720865 cites W2072968157 @default.
• W4362720865 cites W2076783994 @default.
• W4362720865 cites W2079997760 @default.
• W4362720865 cites W2084606805 @default.
• W4362720865 cites W2088475496 @default.
• W4362720865 cites W2096327192 @default.
• W4362720865 cites W2099540110 @default.
• W4362720865 cites W2102414953 @default.
• W4362720865 cites W2103302443 @default.
• W4362720865 cites W2108004092 @default.
• W4362720865 cites W2110107835 @default.
• W4362720865 cites W2116529502 @default.
• W4362720865 cites W2119980381 @default.
• W4362720865 cites W2129429506 @default.
• W4362720865 cites W2130786748 @default.
• W4362720865 cites W2131317633 @default.
• W4362720865 cites W2146784485 @default.
• W4362720865 cites W2146957464 @default.
• W4362720865 cites W2153747443 @default.
• W4362720865 cites W2155524482 @default.
• W4362720865 cites W2161432662 @default.
• W4362720865 cites W2161456065 @default.
• W4362720865 cites W2167279371 @default.
• W4362720865 cites W2314634699 @default.
• W4362720865 cites W2787301818 @default.
• W4362720865 cites W2915416502 @default.
• W4362720865 cites W2947551934 @default.
• W4362720865 cites W2952837230 @default.
• W4362720865 cites W3004547734 @default.
• W4362720865 cites W3026910960 @default.
• W4362720865 cites W3136347409 @default.
• W4362720865 cites W3178113810 @default.
• W4362720865 cites W4229335702 @default.
• W4362720865 cites W4229548299 @default.
• W4362720865 cites W4317376685 @default.
• W4362720865 cites W4367329911 @default.
• W4362720865 cites W613917169 @default.
• W4362720865 doi "https://doi.org/10.1016/j.bbi.2023.04.001" @default.
• W4362720865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37037363" @default.
• W4362720865 hasPublicationYear "2023" @default.
• W4362720865 type Work @default.
• W4362720865 citedByCount "0" @default.
• W4362720865 crossrefType "journal-article" @default.
• W4362720865 hasAuthorship W4362720865A5010466843 @default.
• W4362720865 hasAuthorship W4362720865A5049481404 @default.
• W4362720865 hasAuthorship W4362720865A5072782296 @default.
• W4362720865 hasAuthorship W4362720865A5080036092 @default.
• W4362720865 hasBestOaLocation W43627208651 @default.
• W4362720865 hasConcept C160448771 @default.
• W4362720865 hasConcept C169760540 @default.
• W4362720865 hasConcept C203014093 @default.
• W4362720865 hasConcept C2776914184 @default.
• W4362720865 hasConcept C2779830541 @default.
• W4362720865 hasConcept C86803240 @default.
• W4362720865 hasConcept C95444343 @default.
• W4362720865 hasConceptScore W4362720865C160448771 @default.
• W4362720865 hasConceptScore W4362720865C169760540 @default.
• W4362720865 hasConceptScore W4362720865C203014093 @default.
• W4362720865 hasConceptScore W4362720865C2776914184 @default.
• W4362720865 hasConceptScore W4362720865C2779830541 @default.
• W4362720865 hasConceptScore W4362720865C86803240 @default.
• W4362720865 hasConceptScore W4362720865C95444343 @default.
• W4362720865 hasLocation W43627208651 @default.
• W4362720865 hasLocation W43627208652 @default.
• W4362720865 hasLocation W43627208653 @default.

• next