Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362722229> ?p ?o ?g. }
- W4362722229 endingPage "121817" @default.
- W4362722229 startingPage "121817" @default.
- W4362722229 abstract "The objectives of this work are (1) To scrutinize the various hydrotropes for acting as cinnarizine solubility augmenting excipient, (2) To show the existence of solubility-permeability interplay phenomenon on cinnarizine-hydrotrope blend through an in vitro experimental set up and (3) To apply linear model-based optimization (by using Design Expert® software) for finding out optimum solubility permeability balance on cinnarizine-hydrotrope blend. Among the tested six-different hydrotropic molecules such as nicotinamide, sodium acetate, sodium benzoate, sodium citrate, sodium salicylate and urea, the cinnarizine solubility values were found to increase from 2.39 ± 0.00 to 57.98 ± 0.02 and 150.42 ± 0.02 µg/ml, respectively, for sodium benzoate and sodium salicylate at 40 % w/v concentration levels. However, the solubility enhancement effect produced by these two hydrotropic molecules was occurred at the expense of cinnarizine permeability value (from 44.00 × 10−5 to 35.00 ± 12.00 (×10−5) cm/sec) indicating the presence of solubility-permeability interplay/tradeoff phenomenon. Indeed, the Box-Behnken design yielded the optimized formula for preparing cinnarizine-hydrotrope blends possessing the maximum drug solubility value without significant reduction of drug permeability value. Hence, the quality by design approach plays a crucial role in optimizing the cinnarizine-hydrotropic formulations." @default.
- W4362722229 created "2023-04-09" @default.
- W4362722229 creator A5031798444 @default.
- W4362722229 creator A5040247990 @default.
- W4362722229 creator A5041642344 @default.
- W4362722229 creator A5051884884 @default.
- W4362722229 creator A5059525144 @default.
- W4362722229 date "2023-07-01" @default.
- W4362722229 modified "2023-10-18" @default.
- W4362722229 title "On the use of linear model-based optimization to obtain optimum solubility permeability balance (OSPB) in cinnarizine-hydrotropic blends" @default.
- W4362722229 cites W100843351 @default.
- W4362722229 cites W1970996139 @default.
- W4362722229 cites W1992622173 @default.
- W4362722229 cites W1996145794 @default.
- W4362722229 cites W2005653083 @default.
- W4362722229 cites W2012685645 @default.
- W4362722229 cites W2060280252 @default.
- W4362722229 cites W2064620211 @default.
- W4362722229 cites W2064793405 @default.
- W4362722229 cites W2084985735 @default.
- W4362722229 cites W2088376206 @default.
- W4362722229 cites W2094011022 @default.
- W4362722229 cites W2094323322 @default.
- W4362722229 cites W2100321312 @default.
- W4362722229 cites W2116476289 @default.
- W4362722229 cites W2275887593 @default.
- W4362722229 cites W2461837568 @default.
- W4362722229 cites W2538255296 @default.
- W4362722229 cites W2618411862 @default.
- W4362722229 cites W2762397448 @default.
- W4362722229 cites W2765656332 @default.
- W4362722229 cites W2766856477 @default.
- W4362722229 cites W2792329565 @default.
- W4362722229 cites W2797508402 @default.
- W4362722229 cites W2802848580 @default.
- W4362722229 cites W2810051072 @default.
- W4362722229 cites W2884827416 @default.
- W4362722229 cites W2898076159 @default.
- W4362722229 cites W2898682016 @default.
- W4362722229 cites W2945536695 @default.
- W4362722229 cites W2963601386 @default.
- W4362722229 cites W2990716025 @default.
- W4362722229 cites W2992634898 @default.
- W4362722229 cites W2999623818 @default.
- W4362722229 cites W3007043179 @default.
- W4362722229 cites W3011437037 @default.
- W4362722229 cites W3017990117 @default.
- W4362722229 cites W3110005030 @default.
- W4362722229 cites W3115521689 @default.
- W4362722229 cites W3120388370 @default.
- W4362722229 cites W3128106336 @default.
- W4362722229 cites W3128799819 @default.
- W4362722229 cites W3130203693 @default.
- W4362722229 cites W3135171763 @default.
- W4362722229 cites W3152516273 @default.
- W4362722229 cites W3157432643 @default.
- W4362722229 cites W3159787455 @default.
- W4362722229 cites W3160804642 @default.
- W4362722229 cites W3206715438 @default.
- W4362722229 cites W3212465706 @default.
- W4362722229 cites W3216621998 @default.
- W4362722229 cites W4210960467 @default.
- W4362722229 doi "https://doi.org/10.1016/j.molliq.2023.121817" @default.
- W4362722229 hasPublicationYear "2023" @default.
- W4362722229 type Work @default.
- W4362722229 citedByCount "0" @default.
- W4362722229 crossrefType "journal-article" @default.
- W4362722229 hasAuthorship W4362722229A5031798444 @default.
- W4362722229 hasAuthorship W4362722229A5040247990 @default.
- W4362722229 hasAuthorship W4362722229A5041642344 @default.
- W4362722229 hasAuthorship W4362722229A5051884884 @default.
- W4362722229 hasAuthorship W4362722229A5059525144 @default.
- W4362722229 hasConcept C120882062 @default.
- W4362722229 hasConcept C155574463 @default.
- W4362722229 hasConcept C178790620 @default.
- W4362722229 hasConcept C185592680 @default.
- W4362722229 hasConcept C192562407 @default.
- W4362722229 hasConcept C2776078883 @default.
- W4362722229 hasConcept C2777574038 @default.
- W4362722229 hasConcept C2779134981 @default.
- W4362722229 hasConcept C41625074 @default.
- W4362722229 hasConcept C43617362 @default.
- W4362722229 hasConcept C55493867 @default.
- W4362722229 hasConceptScore W4362722229C120882062 @default.
- W4362722229 hasConceptScore W4362722229C155574463 @default.
- W4362722229 hasConceptScore W4362722229C178790620 @default.
- W4362722229 hasConceptScore W4362722229C185592680 @default.
- W4362722229 hasConceptScore W4362722229C192562407 @default.
- W4362722229 hasConceptScore W4362722229C2776078883 @default.
- W4362722229 hasConceptScore W4362722229C2777574038 @default.
- W4362722229 hasConceptScore W4362722229C2779134981 @default.
- W4362722229 hasConceptScore W4362722229C41625074 @default.
- W4362722229 hasConceptScore W4362722229C43617362 @default.
- W4362722229 hasConceptScore W4362722229C55493867 @default.
- W4362722229 hasLocation W43627222291 @default.
- W4362722229 hasOpenAccess W4362722229 @default.
- W4362722229 hasPrimaryLocation W43627222291 @default.
- W4362722229 hasRelatedWork W1976606316 @default.