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- W4362722260 endingPage "114433" @default.
- W4362722260 startingPage "114433" @default.
- W4362722260 abstract "Social adversity during childhood and adolescence can alter brain development in ways that may increase the likelihood of many prominent mental illnesses. To determine the underlying mechanisms, several animal models have been developed, such as Chronic Early-Life Social Isolation (CELSI), which sees rats isolated for several weeks after weaning. Although such a paradigm does cause many consistent changes in adult behaviour, one area where uncertainty exists concerns its effect upon hippocampal-dependent learning and memory. To help sort out how CELSI affects spatial learning and memory, male and female siblings from 15 Sprague-Dawley rat litters were stratified by sex and then randomly assigned to either group-housing (3 animals/cage), or social isolation (1 animal/cage) for 7 weeks. Spatial learning and memory were then tested over 5 days using the Morris water maze. Next, the animals were euthanised, and stress-sensitive biometrics, including serum corticosterone levels, were collected. Lastly, to determine whether CELSI affected neural cell density, the expression of key neuronal and glial proteins (such as PSD-95 and GFAP, respectively) was assessed in isolated hippocampal tissue using immunoblotting. Notably, both male and female rats that had experienced post-weaning social isolation displayed stronger spatial learning and memory abilities than their group-housed counterparts. As well, socially isolated male rats exhibited a clear increase in expression of PSD-95. However, housing condition did not seem to affect either stress-sensitive biometrics, or hippocampal GFAP expression. Our results support the possibility that CELSI may enhance some aspects of hippocampal-dependent behaviour in a fashion similar among male and female rats." @default.
- W4362722260 created "2023-04-09" @default.
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- W4362722260 date "2023-06-01" @default.
- W4362722260 modified "2023-09-30" @default.
- W4362722260 title "Chronic early-life social isolation enhances spatial memory in male and female rats" @default.
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- W4362722260 doi "https://doi.org/10.1016/j.bbr.2023.114433" @default.
- W4362722260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37037406" @default.
- W4362722260 hasPublicationYear "2023" @default.
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