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- W4362725107 abstract "Polymeric micelles are nano-sized drug delivery carrier systems with a core or shell structure composed of biocompatible and biodegradable amphiphilic block copolymers. Surface functional groups on polymeric micelles allow other molecules to attach to them. Notably, the architectural arrangement of these polymeric micelles offers the benefits of shielding water-sensitive molecules and solubilizing poorly water-soluble drugs via encapsulation. Additionally polymeric micelles serve as carriers having solid-like core that enables them to remain intact for longer hours and provide controlled release of drugs. These polymeric micelles primarily function by circumventing the host defense mechanism, by prolonging the drugs systemic circulation time, reducing the drugs toxicity, and facilitating targeted drug delivery, especially in case of tumors. Literature cites several types of polymeric micelles that have been developed to deliver actives for various illnesses. They can be categorized based on the systems in-built trigger mechanism, such as pH-sensitive, redox-sensitive, glucose-responsive, reacting oxygen species-responsive, hypoxia-responsive, enzyme-triggered, dual-responsive, multi-responsive and extrinsic stimuli-responsive polymeric micelles. Recent advances have proven the feasibility of generating nucleic acid-based, phytoconstituent-loaded, surface engineered, ligand-conjugated, protein-based, and biosensor-based polymeric micelles. The applications of polymeric micelles have been explored in the treatment and diagnosis of conditions such as arthritis, cancer, diabetes, to name a few. Nevertheless, they have also been studied as potential theranostic agents." @default.
- W4362725107 created "2023-04-10" @default.
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- W4362725107 date "2023-01-01" @default.
- W4362725107 modified "2023-09-27" @default.
- W4362725107 title "Types of Polymeric Micelles for Controlled Drug Release" @default.
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- W4362725107 doi "https://doi.org/10.1007/978-981-99-0361-0_4" @default.
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