Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362731605> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4362731605 abstract "Accurate, sensitive and green HPTLC chromatographic method was proposed for simultaneous determination of metformin, glipizide and sitagliptin in the presence of metformin potential toxic impurities melamine and cyanoguanidine. The separation was completed on silica gel HPTLC F254 plates using a mixture of ethyl acetate: methanol: ammonia: formic acid (7: 2: 0.2: 0.2, by volume) as a developing system with UV scanning for the developed bands at 235 nm. The Rf values for metformin, glipizide, sitagliptin, melamine and cyanoguanidine were 0.17, 0.84, 0.67, 0.47 and 0.75, respectively. Linear responses were observed in the ranges of 0.2-3, 0.07-1.5, 1.5-5, 0.8-4 and 0.4-2 μg/band with correlation coefficients of 0.9999, 0.9998, 0.9997, 0.9996 and 0.9998 for metformin, glipizide, sitagliptin, melamine and cyanoguanidine, respectively. The proposed method was validated as per ICH criteria with respect to linearity, accuracy, precision, specificity and robustness. The validated method was successfully applied for determination of the studied drugs in Janumet® and Engilor® tablets; also, the results were statistically compared to those obtained by the reported spectrophotometric method and no significant difference was found between them. This method permitted the accurate simultaneous determination of the studied drugs, indicating its ability to be used for routine quality control assays of these drugs." @default.
- W4362731605 created "2023-04-10" @default.
- W4362731605 creator A5033683744 @default.
- W4362731605 creator A5039516603 @default.
- W4362731605 creator A5047306753 @default.
- W4362731605 creator A5068230459 @default.
- W4362731605 creator A5074199404 @default.
- W4362731605 date "2023-04-06" @default.
- W4362731605 modified "2023-10-16" @default.
- W4362731605 title "Ecofriendly Chromatographic Assay of Metformin Combinations; Content Uniformity Tests and Toxicity Profiling" @default.
- W4362731605 doi "https://doi.org/10.1093/chromsci/bmad026" @default.
- W4362731605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37032120" @default.
- W4362731605 hasPublicationYear "2023" @default.
- W4362731605 type Work @default.
- W4362731605 citedByCount "0" @default.
- W4362731605 crossrefType "journal-article" @default.
- W4362731605 hasAuthorship W4362731605A5033683744 @default.
- W4362731605 hasAuthorship W4362731605A5039516603 @default.
- W4362731605 hasAuthorship W4362731605A5047306753 @default.
- W4362731605 hasAuthorship W4362731605A5068230459 @default.
- W4362731605 hasAuthorship W4362731605A5074199404 @default.
- W4362731605 hasBestOaLocation W43627316051 @default.
- W4362731605 hasConcept C134018914 @default.
- W4362731605 hasConcept C178790620 @default.
- W4362731605 hasConcept C185592680 @default.
- W4362731605 hasConcept C2775979504 @default.
- W4362731605 hasConcept C2779284873 @default.
- W4362731605 hasConcept C2779532046 @default.
- W4362731605 hasConcept C2779555806 @default.
- W4362731605 hasConcept C2780323712 @default.
- W4362731605 hasConcept C43617362 @default.
- W4362731605 hasConcept C555293320 @default.
- W4362731605 hasConcept C71924100 @default.
- W4362731605 hasConceptScore W4362731605C134018914 @default.
- W4362731605 hasConceptScore W4362731605C178790620 @default.
- W4362731605 hasConceptScore W4362731605C185592680 @default.
- W4362731605 hasConceptScore W4362731605C2775979504 @default.
- W4362731605 hasConceptScore W4362731605C2779284873 @default.
- W4362731605 hasConceptScore W4362731605C2779532046 @default.
- W4362731605 hasConceptScore W4362731605C2779555806 @default.
- W4362731605 hasConceptScore W4362731605C2780323712 @default.
- W4362731605 hasConceptScore W4362731605C43617362 @default.
- W4362731605 hasConceptScore W4362731605C555293320 @default.
- W4362731605 hasConceptScore W4362731605C71924100 @default.
- W4362731605 hasLocation W43627316051 @default.
- W4362731605 hasLocation W43627316052 @default.
- W4362731605 hasOpenAccess W4362731605 @default.
- W4362731605 hasPrimaryLocation W43627316051 @default.
- W4362731605 hasRelatedWork W1504374936 @default.
- W4362731605 hasRelatedWork W1583713329 @default.
- W4362731605 hasRelatedWork W1986277873 @default.
- W4362731605 hasRelatedWork W2060960310 @default.
- W4362731605 hasRelatedWork W2063586398 @default.
- W4362731605 hasRelatedWork W2069477789 @default.
- W4362731605 hasRelatedWork W2328107407 @default.
- W4362731605 hasRelatedWork W2387693747 @default.
- W4362731605 hasRelatedWork W3192932278 @default.
- W4362731605 hasRelatedWork W4362731605 @default.
- W4362731605 isParatext "false" @default.
- W4362731605 isRetracted "false" @default.
- W4362731605 workType "article" @default.