Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362735462> ?p ?o ?g. }
- W4362735462 endingPage "108735" @default.
- W4362735462 startingPage "108735" @default.
- W4362735462 abstract "As filter-feeding bivalves, mussels have been traditionally studied as possible vectors of different bacterial or viral pathogens. The absence of a known viral pathogen in these bivalves makes it particularly interesting to study the interaction of the mussel innate immune system with a virus of interest. In the present work, mussels were challenged with viral haemorrhagic septicaemia virus (VHSV), which is a pathogen in several fish species. The viral load was eliminated after 24 h and mussels evidenced antiviral activity towards VHSV, demonstrating that the virus was recognized and eliminated by the immune system of the host and confirming that mussels are not VHSV vectors in the marine environment. The transcriptome activating the antiviral response was studied, revealing the involvement of cytoplasmic viral sensors with the subsequent activation of the JAK-STAT pathway and several downstream antiviral effectors. The inflammatory response was inhibited with the profound downregulation of MyD88, shifting the immune balance towards antiviral functions. High modulation of retrotransposon activity was observed, revealing a mechanism that facilitates the antiviral response and that had not been previously observed in these species. The expression of several inhibitors of apoptosis and apoptosis-promoting genes was modulated, although clear inhibition of apoptosis in bivalves after severe viral infection and subsequent disease was not observed in this study. Finally, the modulated expression of several long noncoding RNAs that were correlated with genes involved in the immune response was detected." @default.
- W4362735462 created "2023-04-11" @default.
- W4362735462 creator A5006562505 @default.
- W4362735462 creator A5044982973 @default.
- W4362735462 creator A5045064610 @default.
- W4362735462 creator A5061485833 @default.
- W4362735462 date "2023-05-01" @default.
- W4362735462 modified "2023-10-09" @default.
- W4362735462 title "Mussel antiviral transcriptome response and elimination of viral haemorrhagic septicaemia virus (VHSV)" @default.
- W4362735462 cites W1507404026 @default.
- W4362735462 cites W1552724685 @default.
- W4362735462 cites W1761750039 @default.
- W4362735462 cites W1959737968 @default.
- W4362735462 cites W1969849940 @default.
- W4362735462 cites W1977040801 @default.
- W4362735462 cites W1984264037 @default.
- W4362735462 cites W1986051096 @default.
- W4362735462 cites W1992421280 @default.
- W4362735462 cites W1993028842 @default.
- W4362735462 cites W2005682161 @default.
- W4362735462 cites W2010843461 @default.
- W4362735462 cites W2019343036 @default.
- W4362735462 cites W2019343097 @default.
- W4362735462 cites W2020310632 @default.
- W4362735462 cites W2033763710 @default.
- W4362735462 cites W2037907723 @default.
- W4362735462 cites W2039370080 @default.
- W4362735462 cites W2048194168 @default.
- W4362735462 cites W2052151391 @default.
- W4362735462 cites W2055667234 @default.
- W4362735462 cites W2056297790 @default.
- W4362735462 cites W2059171191 @default.
- W4362735462 cites W2061068411 @default.
- W4362735462 cites W2065686335 @default.
- W4362735462 cites W2078002276 @default.
- W4362735462 cites W2082322053 @default.
- W4362735462 cites W2086137483 @default.
- W4362735462 cites W2094894770 @default.
- W4362735462 cites W2096402064 @default.
- W4362735462 cites W2103362829 @default.
- W4362735462 cites W2108244474 @default.
- W4362735462 cites W2110373520 @default.
- W4362735462 cites W2121782927 @default.
- W4362735462 cites W2125337655 @default.
- W4362735462 cites W2128303031 @default.
- W4362735462 cites W2138692822 @default.
- W4362735462 cites W2143996730 @default.
- W4362735462 cites W2162186988 @default.
- W4362735462 cites W2165192676 @default.
- W4362735462 cites W2179438025 @default.
- W4362735462 cites W2256756668 @default.
- W4362735462 cites W2294993547 @default.
- W4362735462 cites W233148420 @default.
- W4362735462 cites W2339645512 @default.
- W4362735462 cites W2414707899 @default.
- W4362735462 cites W2423168497 @default.
- W4362735462 cites W2570621777 @default.
- W4362735462 cites W2572305794 @default.
- W4362735462 cites W2613129066 @default.
- W4362735462 cites W2618081368 @default.
- W4362735462 cites W2742768529 @default.
- W4362735462 cites W2760786316 @default.
- W4362735462 cites W2761799169 @default.
- W4362735462 cites W2761891012 @default.
- W4362735462 cites W2775724878 @default.
- W4362735462 cites W2779508968 @default.
- W4362735462 cites W2780112449 @default.
- W4362735462 cites W2799810843 @default.
- W4362735462 cites W2883804343 @default.
- W4362735462 cites W2895636883 @default.
- W4362735462 cites W2901224770 @default.
- W4362735462 cites W2919150694 @default.
- W4362735462 cites W2943696045 @default.
- W4362735462 cites W2950369999 @default.
- W4362735462 cites W2962124564 @default.
- W4362735462 cites W2965529552 @default.
- W4362735462 cites W2979808952 @default.
- W4362735462 cites W2984285153 @default.
- W4362735462 cites W3000637953 @default.
- W4362735462 cites W3016540864 @default.
- W4362735462 cites W3025839606 @default.
- W4362735462 cites W3040482363 @default.
- W4362735462 cites W3043523100 @default.
- W4362735462 cites W3084234138 @default.
- W4362735462 cites W3096642274 @default.
- W4362735462 cites W3098683386 @default.
- W4362735462 cites W3111079910 @default.
- W4362735462 cites W3119839979 @default.
- W4362735462 cites W3120635916 @default.
- W4362735462 cites W3122108557 @default.
- W4362735462 cites W3151864779 @default.
- W4362735462 cites W3151874008 @default.
- W4362735462 cites W3151879664 @default.
- W4362735462 cites W3155763752 @default.
- W4362735462 cites W3162887445 @default.
- W4362735462 cites W3191305784 @default.
- W4362735462 cites W3207219793 @default.
- W4362735462 cites W4220866025 @default.