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- W43630558 abstract "Improvements of blood donor selection, blood processing, histocompatibility, immunohematology, serologic screening for infectious markers, and more recently, the introduction of nucleic acid testing (NAT-tests) for different virus genoms increased the safety of blood transfusion. To date, the transfusion-associated risk of HIV, HBV or HCV (human immunodeficiency virus, hepatitis B or hepatitis C- virus) infection has become negligible in Western communities. However, blood transfusion is not without risk. Transfusion-transmitted infections based on emerging viruses, parasites or mainly bacterial contamination still exist and can lead to severe morbidity and death of the recipient. Techniques with the potential to directly target the possible pathogen, are expected to diminish this residual risk of blood transfusion. Only recently, procedures for pathogen inactivation (PI) of cellular blood components targeting a broad variety of enveloped and non-enveloped viruses, bacteria, parasites as well as leucocytes by targeting nucleic acids have been developed. The mechanism is based on activation of a so-called photosensitizer with defined light sources. The most intensively studied dyes with photodynamic properties are phenothiazines, porphyrins, cyanins, and riboflavin (vitamin B 2 ). Psoralens like S-59 (amotosalen-HCl) have photochemical properties. Other compounds interfere with nucleic acids without an external energy sources (ethylene imine PEN 110) or upon pH-shift (S-303). Because of the possibility to use visible or UV light for treatment, studies on PI of platelet concentrates and plasma are more advanced than with red blood cell concentrates strongly absorbing light of this energy. Other drawbacks of PI procedures for red blood cell concentrates are cellular damage increasing during prolonged storage in case of porphyrins (partly prevented by the addition of oxygen scavengers) and cyanins, the necessity of an integrated, time consuming washing step in addition to unresolved toxicologic questions in case of PEN 110, and antibody formation in case of S-303. PI techniques may become available for blood services and clinicians in the near future. Before implementation, open questions on safety profile of rest substances, cost effectiveness, and the real extent to which PI procedures affect cell function should be answered." @default.
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- W43630558 date "2006-01-01" @default.
- W43630558 modified "2023-10-03" @default.
- W43630558 title "Inactivación de patógenos en productos sanguíneos" @default.
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