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- W4363625517 abstract "Abstract Autoimmune/inflammatory diseases affect many people and are an important cause of global incidence and mortality. Mesenchymal stem cells (MSCs) have low immunogenicity, immune regulation, multidifferentiation and other biological characteristics, play an important role in tissue repair and immune regulation and are widely used in the research and treatment of autoimmune/inflammatory diseases. In addition, MSCs can secrete extracellular vesicles with lipid bilayer structures under resting or activated conditions, including exosomes, microparticles and apoptotic bodies. Among them, exosomes, as the most important component of extracellular vesicles, can function as parent MSCs. Although MSCs and their exosomes have the characteristics of immune regulation and homing, engineering these cells or vesicles through various technical means, such as genetic engineering, surface modification and tissue engineering, can further improve their homing and other congenital characteristics, make them specifically target specific tissues or organs, and improve their therapeutic effect. This article reviews the advanced technology of engineering MSCs or MSC-derived exosomes and its application in some autoimmune/inflammatory diseases by searching the literature published in recent years at home and abroad." @default.
- W4363625517 created "2023-04-11" @default.
- W4363625517 creator A5016550072 @default.
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- W4363625517 creator A5065355624 @default.
- W4363625517 creator A5072319673 @default.
- W4363625517 creator A5077455499 @default.
- W4363625517 date "2023-04-11" @default.
- W4363625517 modified "2023-10-14" @default.
- W4363625517 title "Research progress of engineered mesenchymal stem cells and their derived exosomes and their application in autoimmune/inflammatory diseases" @default.
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