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• W4363648001 startingPage "6908" @default.
• W4363648001 abstract "Postmortem neuropathology shows clear regional differences in many brain diseases. For example, brains from cerebral malaria (CM) patients show more hemorrhagic punctae in the brain’s white matter (WM) than grey matter (GM). The underlying reason for these differential pathologies is unknown. Here, we assessed the effect of the vascular microenvironment on brain endothelial phenotype, focusing endothelial protein C receptor (EPCR). We demonstrate that the basal level of EPCR expression in cerebral microvessels is heterogeneous in the WM compared to the GM. We used in vitro brain endothelial cell cultures and showed that the upregulation of EPCR expression was associated with exposure to oligodendrocyte conditioned media (OCM) compared to astrocyte conditioned media (ACM). Our findings shed light on the origin of the heterogeneity of molecular phenotypes at the microvascular level and might help better understand the variation in pathology seen in CM and other neuropathologies associated with vasculature in various brain regions." @default.
• W4363648001 created "2023-04-11" @default.
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• W4363648001 creator A5077669771 @default.
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• W4363648001 date "2023-04-07" @default.
• W4363648001 modified "2023-09-25" @default.
• W4363648001 title "Microvascular Environment Influences Brain Microvascular Heterogeneity: Relative Roles of Astrocytes and Oligodendrocytes for the EPCR Expression in the Brain Endothelium" @default.
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• W4363648001 doi "https://doi.org/10.3390/ijms24086908" @default.
• W4363648001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37108071" @default.
• W4363648001 hasPublicationYear "2023" @default.
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