Matches in SemOpenAlex for { <https://semopenalex.org/work/W4363648889> ?p ?o ?g. }
- W4363648889 abstract "Abstract Background The emergence and distribution of multidrug-resistant (MDR) and carbapenem-resistant Klebsiella pneumoniae (CRKP) has become a global health threat. Therefore, this study aimed to investigate the frequency and antibiotic resistance patterns of MDR, extensively drug-resistant (XDR), and CRKP, as well as the antibiotic resistance genes of Klebsiella pneumoniae ( K. pneumoniae ) isolates from patients’ infectious samples from central Iran. Methods This study examined 546 clinical samples of patients to identify K. pneumoniae. The isolates were investigated for their antibiotic resistance profile, extended-spectrum β-lactamase (ESBL), AMPC β-lactamase, carbapenemase resistance, sulfonamide, tetracycline, plasmid-mediated quinolone resistance (PMQR) along with their resistance genes, integrase, and quaternary ammonium compounds ( qac ) by polymerase chain reaction (PCR). Results Out of 546 clinical samples, 121 (22.1%) cases of K. pneumoniae were identified using culture and PCR methods. The highest antibiotic resistance rates were found for ampicillin (119/121; 98.3%), cotrimoxazole (78/121; 64.4%), and cefixime, cefotaxime, ceftriaxone, and ceftazidime as a group (77/121; 63.6%). Tigecycline, colistin, and fosfomycin were the most effective antimicrobial agents with 98.4%, 96.7%, and 95.9% susceptibility, respectively. The amount of CRKP was 51 (42.1%). All CRKP isolates were MDR. The most abundant genes were bla TEM (77/77; 100%), bla CTX−M1 (76/77; 98.7%), bla SHV (76/77; 98.7%), bla CTX−M15 (73/77; 94.8%) for ESBL; bla CIT 28 (48.3%) and bla CMY−2 26 (44.8%) for AMPC β-lactamase; and bla OXA−48 46 (90.1%) and bla NDM 36 (70.5%) for carbapenemase. Among the PMQR determinants, qnrB (25/52; 48%), qnrS (19/52; 36.5%), and qnrA (11/52; 21.1%) were positive from the isolates. TetA and tetB were recognized in 25 (44.6%) and 17 (30.3%) isolates, respectively. Class 1 and 2 integrons were recognized in 97 (80.1%) and 53 (43.8%) isolates, respectively. Conclusions Due to the high prevalence of MDR and CRKP in central Iran, tracking and immediate intervention are necessary for control and inhibition of K. pneumoniae resistant isolates. Tigecycline, colistin, and fosfomycin are the best treatment options for treatment of patients with CRKP in this geographical area." @default.
- W4363648889 created "2023-04-11" @default.
- W4363648889 creator A5059632282 @default.
- W4363648889 creator A5080698288 @default.
- W4363648889 date "2023-04-11" @default.
- W4363648889 modified "2023-10-14" @default.
- W4363648889 title "High frequency of NDM-1 and OXA-48 carbapenemase genes among Klebsiella pneumoniae isolates in central Iran" @default.
- W4363648889 cites W1910505582 @default.
- W4363648889 cites W2024263059 @default.
- W4363648889 cites W2057357016 @default.
- W4363648889 cites W2106065775 @default.
- W4363648889 cites W2111701009 @default.
- W4363648889 cites W2761474991 @default.
- W4363648889 cites W2791931354 @default.
- W4363648889 cites W2896482349 @default.
- W4363648889 cites W2905067857 @default.
- W4363648889 cites W2908103197 @default.
- W4363648889 cites W2913655639 @default.
- W4363648889 cites W2948843669 @default.
- W4363648889 cites W3013447254 @default.
- W4363648889 cites W3020666269 @default.
- W4363648889 cites W3024286847 @default.
- W4363648889 cites W3029999971 @default.
- W4363648889 cites W3048013375 @default.
- W4363648889 cites W3048134059 @default.
- W4363648889 cites W3088877489 @default.
- W4363648889 cites W3107665608 @default.
- W4363648889 cites W3112415478 @default.
- W4363648889 cites W3120583897 @default.
- W4363648889 cites W3128834624 @default.
- W4363648889 cites W3135811771 @default.
- W4363648889 cites W3150979287 @default.
- W4363648889 cites W3162084115 @default.
- W4363648889 cites W3195034945 @default.
- W4363648889 cites W3204560283 @default.
- W4363648889 cites W4200386557 @default.
- W4363648889 cites W4205525155 @default.
- W4363648889 cites W4281695417 @default.
- W4363648889 cites W4296558396 @default.
- W4363648889 cites W4304175289 @default.
- W4363648889 doi "https://doi.org/10.1186/s12866-023-02840-x" @default.
- W4363648889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37038144" @default.
- W4363648889 hasPublicationYear "2023" @default.
- W4363648889 type Work @default.
- W4363648889 citedByCount "3" @default.
- W4363648889 countsByYear W43636488892023 @default.
- W4363648889 crossrefType "journal-article" @default.
- W4363648889 hasAuthorship W4363648889A5059632282 @default.
- W4363648889 hasAuthorship W4363648889A5080698288 @default.
- W4363648889 hasBestOaLocation W43636488891 @default.
- W4363648889 hasConcept C104317684 @default.
- W4363648889 hasConcept C114851261 @default.
- W4363648889 hasConcept C2776968632 @default.
- W4363648889 hasConcept C2777027569 @default.
- W4363648889 hasConcept C2777058267 @default.
- W4363648889 hasConcept C2777427914 @default.
- W4363648889 hasConcept C2777637488 @default.
- W4363648889 hasConcept C2778243283 @default.
- W4363648889 hasConcept C2778719061 @default.
- W4363648889 hasConcept C2778897966 @default.
- W4363648889 hasConcept C2779259085 @default.
- W4363648889 hasConcept C501593827 @default.
- W4363648889 hasConcept C523546767 @default.
- W4363648889 hasConcept C54355233 @default.
- W4363648889 hasConcept C547475151 @default.
- W4363648889 hasConcept C55493867 @default.
- W4363648889 hasConcept C64778159 @default.
- W4363648889 hasConcept C86803240 @default.
- W4363648889 hasConcept C89423630 @default.
- W4363648889 hasConcept C94665300 @default.
- W4363648889 hasConceptScore W4363648889C104317684 @default.
- W4363648889 hasConceptScore W4363648889C114851261 @default.
- W4363648889 hasConceptScore W4363648889C2776968632 @default.
- W4363648889 hasConceptScore W4363648889C2777027569 @default.
- W4363648889 hasConceptScore W4363648889C2777058267 @default.
- W4363648889 hasConceptScore W4363648889C2777427914 @default.
- W4363648889 hasConceptScore W4363648889C2777637488 @default.
- W4363648889 hasConceptScore W4363648889C2778243283 @default.
- W4363648889 hasConceptScore W4363648889C2778719061 @default.
- W4363648889 hasConceptScore W4363648889C2778897966 @default.
- W4363648889 hasConceptScore W4363648889C2779259085 @default.
- W4363648889 hasConceptScore W4363648889C501593827 @default.
- W4363648889 hasConceptScore W4363648889C523546767 @default.
- W4363648889 hasConceptScore W4363648889C54355233 @default.
- W4363648889 hasConceptScore W4363648889C547475151 @default.
- W4363648889 hasConceptScore W4363648889C55493867 @default.
- W4363648889 hasConceptScore W4363648889C64778159 @default.
- W4363648889 hasConceptScore W4363648889C86803240 @default.
- W4363648889 hasConceptScore W4363648889C89423630 @default.
- W4363648889 hasConceptScore W4363648889C94665300 @default.
- W4363648889 hasIssue "1" @default.
- W4363648889 hasLocation W43636488891 @default.
- W4363648889 hasLocation W43636488892 @default.
- W4363648889 hasLocation W43636488893 @default.
- W4363648889 hasOpenAccess W4363648889 @default.
- W4363648889 hasPrimaryLocation W43636488891 @default.
- W4363648889 hasRelatedWork W2149625795 @default.
- W4363648889 hasRelatedWork W2167256781 @default.
- W4363648889 hasRelatedWork W2323305812 @default.
- W4363648889 hasRelatedWork W2712120856 @default.