Matches in SemOpenAlex for { <https://semopenalex.org/work/W4363650981> ?p ?o ?g. }
- W4363650981 endingPage "1820" @default.
- W4363650981 startingPage "1820" @default.
- W4363650981 abstract "Drugs providing antihypertensive and protective cardiovascular actions are of clinical interest in controlling cardiovascular events and slowing the progression of kidney disease. We studied the effect of a hybrid compound, GGN1231 (derived from losartan in which a powerful antioxidant was attached), on the prevention of cardiovascular damage, cardiac hypertrophy, and fibrosis in a rat model of severe chronic renal failure (CRF). CRF by a 7/8 nephrectomy was carried out in male Wistar rats fed with a diet rich in phosphorous (0.9%) and normal calcium (0.6%) for a period of 12 weeks until sacrifice. In week 8, rats were randomized in five groups receiving different drugs including dihydrocaffeic acid as antioxidant (Aox), losartan (Los), dihydrocaffeic acid+losartan (Aox+Los) and GGN1231 as follows: Group 1 (CRF+vehicle group), Group 2 (CRF+Aox group), Group 3 (CRF+Los group), Group 4 (CRF+Aox+Los group), and Group 5 (CRF+GGN1231 group). Group 5, the CRF+GGN1231 group, displayed reduced proteinuria, aortic TNF-α, blood pressure, LV wall thickness, diameter of the cardiomyocytes, ATR1, cardiac TNF-α and fibrosis, cardiac collagen I, and TGF-β1 expression. A non-significant 20% reduction in the mortality was also observed. This study showed the possible advantages of GGN1231, which could help in the management of cardiovascular and inflammatory processes. Further research is needed to confirm and even expand the positive aspects of this compound." @default.
- W4363650981 created "2023-04-11" @default.
- W4363650981 creator A5005547841 @default.
- W4363650981 creator A5013366022 @default.
- W4363650981 creator A5020844169 @default.
- W4363650981 creator A5024590827 @default.
- W4363650981 creator A5028326490 @default.
- W4363650981 creator A5032650696 @default.
- W4363650981 creator A5034673572 @default.
- W4363650981 creator A5057833421 @default.
- W4363650981 creator A5073028441 @default.
- W4363650981 creator A5077049610 @default.
- W4363650981 creator A5078271559 @default.
- W4363650981 creator A5078531343 @default.
- W4363650981 creator A5088347952 @default.
- W4363650981 creator A5091624171 @default.
- W4363650981 date "2023-04-10" @default.
- W4363650981 modified "2023-10-18" @default.
- W4363650981 title "Effects of a Losartan-Antioxidant Hybrid (GGN1231) on Vascular and Cardiac Health in an Experimental Model of Chronic Renal Failure" @default.
- W4363650981 cites W1970184528 @default.
- W4363650981 cites W1979875909 @default.
- W4363650981 cites W2000166679 @default.
- W4363650981 cites W2012767819 @default.
- W4363650981 cites W2017173759 @default.
- W4363650981 cites W2023908282 @default.
- W4363650981 cites W2052780003 @default.
- W4363650981 cites W2058058155 @default.
- W4363650981 cites W2065953025 @default.
- W4363650981 cites W2098030130 @default.
- W4363650981 cites W2101222842 @default.
- W4363650981 cites W2104007366 @default.
- W4363650981 cites W2107277218 @default.
- W4363650981 cites W2125586000 @default.
- W4363650981 cites W2135804267 @default.
- W4363650981 cites W2136725726 @default.
- W4363650981 cites W2141108790 @default.
- W4363650981 cites W2162232882 @default.
- W4363650981 cites W2166935305 @default.
- W4363650981 cites W2172011106 @default.
- W4363650981 cites W2192080449 @default.
- W4363650981 cites W2280737718 @default.
- W4363650981 cites W2312201455 @default.
- W4363650981 cites W2523854757 @default.
- W4363650981 cites W2743079615 @default.
- W4363650981 cites W2764157735 @default.
- W4363650981 cites W2890790548 @default.
- W4363650981 cites W2899473641 @default.
- W4363650981 cites W2903460914 @default.
- W4363650981 cites W2904356389 @default.
- W4363650981 cites W2928978870 @default.
- W4363650981 cites W2971555794 @default.
- W4363650981 cites W3108206064 @default.
- W4363650981 cites W3124115229 @default.
- W4363650981 cites W3216221322 @default.
- W4363650981 cites W4205336258 @default.
- W4363650981 cites W4224291390 @default.
- W4363650981 cites W4249341602 @default.
- W4363650981 cites W4289516618 @default.
- W4363650981 cites W4308786696 @default.
- W4363650981 cites W4313332807 @default.
- W4363650981 cites W4318754432 @default.
- W4363650981 doi "https://doi.org/10.3390/nu15081820" @default.
- W4363650981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37111038" @default.
- W4363650981 hasPublicationYear "2023" @default.
- W4363650981 type Work @default.
- W4363650981 citedByCount "0" @default.
- W4363650981 crossrefType "journal-article" @default.
- W4363650981 hasAuthorship W4363650981A5005547841 @default.
- W4363650981 hasAuthorship W4363650981A5013366022 @default.
- W4363650981 hasAuthorship W4363650981A5020844169 @default.
- W4363650981 hasAuthorship W4363650981A5024590827 @default.
- W4363650981 hasAuthorship W4363650981A5028326490 @default.
- W4363650981 hasAuthorship W4363650981A5032650696 @default.
- W4363650981 hasAuthorship W4363650981A5034673572 @default.
- W4363650981 hasAuthorship W4363650981A5057833421 @default.
- W4363650981 hasAuthorship W4363650981A5073028441 @default.
- W4363650981 hasAuthorship W4363650981A5077049610 @default.
- W4363650981 hasAuthorship W4363650981A5078271559 @default.
- W4363650981 hasAuthorship W4363650981A5078531343 @default.
- W4363650981 hasAuthorship W4363650981A5088347952 @default.
- W4363650981 hasAuthorship W4363650981A5091624171 @default.
- W4363650981 hasBestOaLocation W43636509811 @default.
- W4363650981 hasConcept C126322002 @default.
- W4363650981 hasConcept C134018914 @default.
- W4363650981 hasConcept C164705383 @default.
- W4363650981 hasConcept C185592680 @default.
- W4363650981 hasConcept C2776151105 @default.
- W4363650981 hasConcept C2777420927 @default.
- W4363650981 hasConcept C2778004101 @default.
- W4363650981 hasConcept C2778198053 @default.
- W4363650981 hasConcept C2780288358 @default.
- W4363650981 hasConcept C2780559512 @default.
- W4363650981 hasConcept C2908929049 @default.
- W4363650981 hasConcept C55493867 @default.
- W4363650981 hasConcept C71924100 @default.
- W4363650981 hasConcept C84393581 @default.
- W4363650981 hasConceptScore W4363650981C126322002 @default.
- W4363650981 hasConceptScore W4363650981C134018914 @default.