Matches in SemOpenAlex for { <https://semopenalex.org/work/W4363651521> ?p ?o ?g. }
- W4363651521 endingPage "928" @default.
- W4363651521 startingPage "918" @default.
- W4363651521 abstract "ABSTRACT Proper bone remodeling depends not only on a team of bone‐resorbing osteoclasts and bone‐forming osteoblasts. It also depends on the site‐specific delivery of a large amount of osteoblast lineage cells to the bone remodeling site. How this delivery occurs is poorly known. Here, we gained insight into this mechanism by analyzing the distribution of markers of osteoblastogenesis on bone surfaces and in their bone marrow neighborhood in human cancellous bone. We found a CD271‐positive/PDGFβ‐R‐positive cell layer surrounding the bone marrow that provides osteoblastogenic potential along all bone surfaces, whether quiescent or remodeling. This bone marrow envelope cell layer takes the appearance of a canopy above remodeling sites, where it then also shows an upregulation of the proliferation marker Ki67, smooth muscle actin (SMA), tenascin C, fibronectin, and MMP13. This indicates that the canopy is a region of the bone marrow envelope where early markers of osteoblastogenesis are activated concurrently with initiation of bone remodeling. Importantly, the high proliferation index in the canopy is not associated with increasing cell densities at the canopy level, but it is at the bone surface level, thereby supporting delivery of cells from the canopy to the bone surface. This delivery route explains why lack of canopies was previously found to coincide with lack of bone formation, and fits current knowledge on the canopies as a target for regulators of bone remodeling. We conclude that the coordination of bone marrow envelope activities and bone surface activities allows integrating osteoblastogenesis and bone remodeling into the same functional unit, and propose that the bone marrow envelope is critical for preserving bone health. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR)." @default.
- W4363651521 created "2023-04-11" @default.
- W4363651521 creator A5036824028 @default.
- W4363651521 creator A5049717703 @default.
- W4363651521 creator A5059821476 @default.
- W4363651521 creator A5066576087 @default.
- W4363651521 creator A5086800175 @default.
- W4363651521 creator A5091340732 @default.
- W4363651521 date "2023-05-08" @default.
- W4363651521 modified "2023-09-30" @default.
- W4363651521 title "A critical role of the bone marrow envelope in human bone remodeling" @default.
- W4363651521 cites W117344629 @default.
- W4363651521 cites W1802397357 @default.
- W4363651521 cites W1968326919 @default.
- W4363651521 cites W1974208182 @default.
- W4363651521 cites W1989343687 @default.
- W4363651521 cites W1999156648 @default.
- W4363651521 cites W2000903026 @default.
- W4363651521 cites W2010224562 @default.
- W4363651521 cites W2015329065 @default.
- W4363651521 cites W2018040433 @default.
- W4363651521 cites W2019426043 @default.
- W4363651521 cites W2020469763 @default.
- W4363651521 cites W2026578311 @default.
- W4363651521 cites W2033771804 @default.
- W4363651521 cites W2047122338 @default.
- W4363651521 cites W2049646783 @default.
- W4363651521 cites W2051577992 @default.
- W4363651521 cites W2054602383 @default.
- W4363651521 cites W2061560867 @default.
- W4363651521 cites W2064123337 @default.
- W4363651521 cites W2065308524 @default.
- W4363651521 cites W2069880945 @default.
- W4363651521 cites W2074621479 @default.
- W4363651521 cites W2078489918 @default.
- W4363651521 cites W2085390592 @default.
- W4363651521 cites W2086805722 @default.
- W4363651521 cites W2114948431 @default.
- W4363651521 cites W2118939519 @default.
- W4363651521 cites W2132309525 @default.
- W4363651521 cites W2136345671 @default.
- W4363651521 cites W2140471106 @default.
- W4363651521 cites W2156732345 @default.
- W4363651521 cites W2158079848 @default.
- W4363651521 cites W2168002240 @default.
- W4363651521 cites W2254323254 @default.
- W4363651521 cites W2315374864 @default.
- W4363651521 cites W2332875861 @default.
- W4363651521 cites W2483820928 @default.
- W4363651521 cites W2563499543 @default.
- W4363651521 cites W2585731279 @default.
- W4363651521 cites W2586325787 @default.
- W4363651521 cites W2606663768 @default.
- W4363651521 cites W2769260297 @default.
- W4363651521 cites W2793050664 @default.
- W4363651521 cites W2910083643 @default.
- W4363651521 cites W2912817638 @default.
- W4363651521 cites W2921584057 @default.
- W4363651521 cites W2927412502 @default.
- W4363651521 cites W2928803385 @default.
- W4363651521 cites W2959297385 @default.
- W4363651521 cites W2977240403 @default.
- W4363651521 cites W2988737059 @default.
- W4363651521 cites W3006236315 @default.
- W4363651521 cites W3040096882 @default.
- W4363651521 cites W3047740954 @default.
- W4363651521 cites W3083261547 @default.
- W4363651521 cites W3125359716 @default.
- W4363651521 cites W3126537545 @default.
- W4363651521 cites W3142448953 @default.
- W4363651521 cites W3154243080 @default.
- W4363651521 cites W4200319697 @default.
- W4363651521 cites W4210419475 @default.
- W4363651521 cites W4211215115 @default.
- W4363651521 cites W4282939100 @default.
- W4363651521 cites W84497161 @default.
- W4363651521 doi "https://doi.org/10.1002/jbmr.4815" @default.
- W4363651521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37038371" @default.
- W4363651521 hasPublicationYear "2023" @default.
- W4363651521 type Work @default.
- W4363651521 citedByCount "2" @default.
- W4363651521 countsByYear W43636515212023 @default.
- W4363651521 crossrefType "journal-article" @default.
- W4363651521 hasAuthorship W4363651521A5036824028 @default.
- W4363651521 hasAuthorship W4363651521A5049717703 @default.
- W4363651521 hasAuthorship W4363651521A5059821476 @default.
- W4363651521 hasAuthorship W4363651521A5066576087 @default.
- W4363651521 hasAuthorship W4363651521A5086800175 @default.
- W4363651521 hasAuthorship W4363651521A5091340732 @default.
- W4363651521 hasBestOaLocation W43636515211 @default.
- W4363651521 hasConcept C105702510 @default.
- W4363651521 hasConcept C12021080 @default.
- W4363651521 hasConcept C133605539 @default.
- W4363651521 hasConcept C134018914 @default.
- W4363651521 hasConcept C170033053 @default.
- W4363651521 hasConcept C185592680 @default.
- W4363651521 hasConcept C202751555 @default.
- W4363651521 hasConcept C203014093 @default.