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- W4363651623 abstract "Introduction Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid-β (Aβ) in brain vessels and is a main cause of lobar intracerebral hemorrhage (ICH) in the elderly. CAA is associated with magnetic resonance imaging (MRI) markers of small vessel disease (SVD). Since Aβ is also accumulated in Alzheimer’s disease (AD) in the brain parenchyma, we aimed to study if several single nucleotide polymorphisms (SNPs) previously associated with AD were also associated with CAA pathology. Furthermore, we also studied the influence of APOE and CLU genetic variants in apolipoprotein E (ApoE) and clusterin/apolipoprotein J (ApoJ) circulating levels and their distribution among lipoproteins. Methods The study was carried out in a multicentric cohort of 126 patients with lobar ICH and clinical suspicion of CAA. Results We observed several SNPs associated with CAA neuroimaging MRI markers [cortical superficial siderosis (cSS), enlarged perivascular spaces in the centrum semiovale (CSO-EPVS), lobar cerebral microbleeds (CMB), white matter hyperintensities (WMH), corticosubcortical atrophy and CAA-SVD burden score]. Concretely, ABCA7 (rs3764650), CLU (rs9331896 and rs933188), EPHA1 (rs11767557), and TREML2 (rs3747742) were significantly associated with a CAA-SVD burden score. Regarding circulating levels of apolipoproteins, protective AD SNPs of CLU [rs11136000 (T) and rs9331896 (C)] were significantly associated with higher HDL ApoJ content in the lobar ICH cohort. APOEε2 carriers presented higher plasma and LDL-associated ApoE levels whereas APOEε4 carriers presented lower plasma ApoE levels. Additionally, we observed that lower circulating ApoJ and ApoE levels were significantly associated with CAA-related MRI markers. More specifically, lower LDL-associated ApoJ and plasma and HDL-associated ApoE levels were significantly associated with CSO-EPVS, lower ApoJ content in HDL with brain atrophy and lower ApoE content in LDL with the extent of cSS. Discussion This study reinforces the relevance of lipid metabolism in CAA and cerebrovascular functionality. We propose that ApoJ and ApoE distribution among lipoproteins may be associated with pathological features related to CAA with higher ApoE and ApoJ levels in HDL possibly enhancing atheroprotective, antioxidative, and anti-inflammatory responses in cerebral β-amyloidosis." @default.
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- W4363651623 date "2023-04-11" @default.
- W4363651623 modified "2023-10-18" @default.
- W4363651623 title "Association of candidate genetic variants and circulating levels of ApoE/ApoJ with common neuroimaging features of cerebral amyloid angiopathy" @default.
- W4363651623 cites W1484803981 @default.
- W4363651623 cites W1514728774 @default.
- W4363651623 cites W1752389919 @default.
- W4363651623 cites W1765586858 @default.
- W4363651623 cites W1964251512 @default.
- W4363651623 cites W1964828595 @default.
- W4363651623 cites W1965544005 @default.
- W4363651623 cites W1993223982 @default.
- W4363651623 cites W1995037165 @default.
- W4363651623 cites W1997279602 @default.
- W4363651623 cites W1998498074 @default.
- W4363651623 cites W1999794509 @default.
- W4363651623 cites W2001688761 @default.
- W4363651623 cites W2005257697 @default.
- W4363651623 cites W2031157188 @default.
- W4363651623 cites W2041396523 @default.
- W4363651623 cites W2046459425 @default.
- W4363651623 cites W2062901418 @default.
- W4363651623 cites W2067766876 @default.
- W4363651623 cites W2081061369 @default.
- W4363651623 cites W2090747948 @default.
- W4363651623 cites W2091931051 @default.
- W4363651623 cites W2104549677 @default.
- W4363651623 cites W2105752911 @default.
- W4363651623 cites W2115779804 @default.
- W4363651623 cites W2138746692 @default.
- W4363651623 cites W2140269404 @default.
- W4363651623 cites W2148972503 @default.
- W4363651623 cites W2152119060 @default.
- W4363651623 cites W2158742097 @default.
- W4363651623 cites W2163480552 @default.
- W4363651623 cites W2169851819 @default.
- W4363651623 cites W2218501505 @default.
- W4363651623 cites W2223656268 @default.
- W4363651623 cites W2277380679 @default.
- W4363651623 cites W2289333406 @default.
- W4363651623 cites W2399571624 @default.
- W4363651623 cites W2405825843 @default.
- W4363651623 cites W2415290091 @default.
- W4363651623 cites W2469367031 @default.
- W4363651623 cites W2480884242 @default.
- W4363651623 cites W2538539323 @default.
- W4363651623 cites W2590987049 @default.
- W4363651623 cites W2591809865 @default.
- W4363651623 cites W2596892842 @default.
- W4363651623 cites W2610445920 @default.
- W4363651623 cites W2731876108 @default.
- W4363651623 cites W2737274080 @default.
- W4363651623 cites W2765860455 @default.
- W4363651623 cites W2783036891 @default.
- W4363651623 cites W2890035992 @default.
- W4363651623 cites W2906709963 @default.
- W4363651623 cites W2920516237 @default.
- W4363651623 cites W2921820524 @default.
- W4363651623 cites W2933238633 @default.
- W4363651623 cites W2995183059 @default.
- W4363651623 cites W2997924781 @default.
- W4363651623 cites W3013478994 @default.
- W4363651623 cites W3018807282 @default.
- W4363651623 cites W3029274435 @default.
- W4363651623 cites W3081542127 @default.
- W4363651623 cites W3111203418 @default.
- W4363651623 cites W3120310655 @default.
- W4363651623 cites W3135651539 @default.
- W4363651623 cites W3136892504 @default.
- W4363651623 cites W3147421655 @default.
- W4363651623 cites W3162741514 @default.
- W4363651623 cites W3214092816 @default.
- W4363651623 cites W3217338325 @default.
- W4363651623 cites W4200513940 @default.
- W4363651623 cites W4206774749 @default.
- W4363651623 cites W4230870013 @default.
- W4363651623 cites W4246100355 @default.
- W4363651623 cites W4281758244 @default.
- W4363651623 cites W4285084802 @default.