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- W4363672327 abstract "Stem cell therapy shows promise for multiple disorders; however, the molecular crosstalk between grafted cells and host tissue is largely unknown. Here, we take a step toward addressing this question. Using translating ribosome affinity purification (TRAP) with sequencing tools, we simultaneously decode the transcriptomes of graft and host for human neural stem cells (hNSCs) transplanted into the stroke-injured rat brain. Employing pathway analysis tools, we investigate the interactions between the two transcriptomes to predict molecular pathways linking host and graft genes; as proof of concept, we predict host-secreted factors that signal to the graft and the downstream molecular cascades they trigger in the graft. We identify a potential host-graft crosstalk pathway where BMP6 from the stroke-injured brain induces graft secretion of noggin, a known brain repair factor. Decoding the molecular interplay between graft and host is a critical step toward deciphering the molecular mechanisms of stem cell action." @default.
- W4363672327 created "2023-04-11" @default.
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- W4363672327 date "2023-04-01" @default.
- W4363672327 modified "2023-10-12" @default.
- W4363672327 title "Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain" @default.
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- W4363672327 doi "https://doi.org/10.1016/j.celrep.2023.112353" @default.
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