FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4363672395> ?p ?o ?g. }

• W4363672395 endingPage "300" @default.
• W4363672395 startingPage "289" @default.
• W4363672395 abstract "Purpose: To assess the efficacy of total neoadjuvant therapy (TNT) for rectal carcinoma in comparison with conventional chemoradiotherapy (CRT).Methods: A systematic review was performed according to the PRISMA guidelines. A Bayesian network meta-analysis was done using NetMetaXL and WinBUGS. This study was registered in PROSPERO on March 3, 2022 (No. CRD-42022307867).Results: Outcomes of 2,719 patients from 10 randomized trials between 2010 and 2022 were selected. Of these 1,191 (44%) had conventional long-course CRT (50–54 Gy) and capecitabine, 506 (18%) had induction chemotherapy followed by CRT (50–54 Gy) and capecitabine (iTNT), 230 (9%) had long-course CRT (50–54 Gy) followed by consolidation chemotherapy (cTNT), and 792 (29%) undergone modified short-course radiotherapy (25 Gy) with subsequent chemotherapy (mTNT). Total pathologic complete response (pCR) was 20% in the iTNT group, 21% in the mTNT group, 22% in the cTNT group, and 12% in the CRT group. Statistically significant difference in pCR rates was detected when comparing iTNT with CRT (odds ratio [OR], 1.76; 95% credible interval [CrI], 1.06–2.8), mTNT with CRT (OR, 1.90; 95% CrI, 1.25–2.74), and cTNT with CRT groups (OR, 2.54; 95% CrI, 1.26–5.08). No differences were found in R0 resection rates. No significant difference was found in long-term outcomes.Conclusion: The early administration of systemic chemotherapy in the TNT regimen has improved short-term outcomes, though long-term results are underreported. Randomized trials with survival as the endpoint are necessary to evaluate the possible advantages of TNT modes." @default.
• W4363672395 created "2023-04-11" @default.
• W4363672395 creator A5018510910 @default.
• W4363672395 creator A5026050389 @default.
• W4363672395 creator A5039324784 @default.
• W4363672395 creator A5061602253 @default.
• W4363672395 creator A5069834091 @default.
• W4363672395 creator A5076100760 @default.
• W4363672395 creator A5080609216 @default.
• W4363672395 creator A5088329305 @default.
• W4363672395 date "2023-08-31" @default.
• W4363672395 modified "2023-09-27" @default.
• W4363672395 title "Total neoadjuvant therapy in rectal cancer: a network meta-analysis of randomized trials" @default.
• W4363672395 cites W1928621270 @default.
• W4363672395 cites W1992968014 @default.
• W4363672395 cites W1995782290 @default.
• W4363672395 cites W2003589572 @default.
• W4363672395 cites W2013457956 @default.
• W4363672395 cites W2047778994 @default.
• W4363672395 cites W2057901226 @default.
• W4363672395 cites W2073631512 @default.
• W4363672395 cites W2100241851 @default.
• W4363672395 cites W2101719692 @default.
• W4363672395 cites W2109391487 @default.
• W4363672395 cites W2110154965 @default.
• W4363672395 cites W2118950501 @default.
• W4363672395 cites W2124886112 @default.
• W4363672395 cites W2125452425 @default.
• W4363672395 cites W2131701504 @default.
• W4363672395 cites W2143655828 @default.
• W4363672395 cites W2144495943 @default.
• W4363672395 cites W2146340574 @default.
• W4363672395 cites W2161523093 @default.
• W4363672395 cites W2171573992 @default.
• W4363672395 cites W2188262339 @default.
• W4363672395 cites W2305876893 @default.
• W4363672395 cites W2615647422 @default.
• W4363672395 cites W2796565923 @default.
• W4363672395 cites W2802327405 @default.
• W4363672395 cites W2947040388 @default.
• W4363672395 cites W2949733640 @default.
• W4363672395 cites W2978795816 @default.
• W4363672395 cites W2991792334 @default.
• W4363672395 cites W3015163167 @default.
• W4363672395 cites W3039450521 @default.
• W4363672395 cites W3111308000 @default.
• W4363672395 cites W3138239215 @default.
• W4363672395 cites W3154995350 @default.
• W4363672395 cites W4294215472 @default.
• W4363672395 doi "https://doi.org/10.3393/ac.2022.00920.0131" @default.
• W4363672395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37038270" @default.
• W4363672395 hasPublicationYear "2023" @default.
• W4363672395 type Work @default.
• W4363672395 citedByCount "0" @default.
• W4363672395 crossrefType "journal-article" @default.
• W4363672395 hasAuthorship W4363672395A5018510910 @default.
• W4363672395 hasAuthorship W4363672395A5026050389 @default.
• W4363672395 hasAuthorship W4363672395A5039324784 @default.
• W4363672395 hasAuthorship W4363672395A5061602253 @default.
• W4363672395 hasAuthorship W4363672395A5069834091 @default.
• W4363672395 hasAuthorship W4363672395A5076100760 @default.
• W4363672395 hasAuthorship W4363672395A5080609216 @default.
• W4363672395 hasAuthorship W4363672395A5088329305 @default.
• W4363672395 hasBestOaLocation W43636723951 @default.
• W4363672395 hasConcept C121608353 @default.
• W4363672395 hasConcept C126322002 @default.
• W4363672395 hasConcept C141071460 @default.
• W4363672395 hasConcept C143998085 @default.
• W4363672395 hasConcept C168563851 @default.
• W4363672395 hasConcept C2776694085 @default.
• W4363672395 hasConcept C2777909004 @default.
• W4363672395 hasConcept C2778292576 @default.
• W4363672395 hasConcept C44249647 @default.
• W4363672395 hasConcept C509974204 @default.
• W4363672395 hasConcept C526805850 @default.
• W4363672395 hasConcept C530470458 @default.
• W4363672395 hasConcept C71924100 @default.
• W4363672395 hasConceptScore W4363672395C121608353 @default.
• W4363672395 hasConceptScore W4363672395C126322002 @default.
• W4363672395 hasConceptScore W4363672395C141071460 @default.
• W4363672395 hasConceptScore W4363672395C143998085 @default.
• W4363672395 hasConceptScore W4363672395C168563851 @default.
• W4363672395 hasConceptScore W4363672395C2776694085 @default.
• W4363672395 hasConceptScore W4363672395C2777909004 @default.
• W4363672395 hasConceptScore W4363672395C2778292576 @default.
• W4363672395 hasConceptScore W4363672395C44249647 @default.
• W4363672395 hasConceptScore W4363672395C509974204 @default.
• W4363672395 hasConceptScore W4363672395C526805850 @default.
• W4363672395 hasConceptScore W4363672395C530470458 @default.
• W4363672395 hasConceptScore W4363672395C71924100 @default.
• W4363672395 hasIssue "4" @default.
• W4363672395 hasLocation W43636723951 @default.
• W4363672395 hasLocation W43636723952 @default.
• W4363672395 hasOpenAccess W4363672395 @default.
• W4363672395 hasPrimaryLocation W43636723951 @default.
• W4363672395 hasRelatedWork W2002928668 @default.
• W4363672395 hasRelatedWork W2029040122 @default.
• W4363672395 hasRelatedWork W2032042555 @default.

• next