FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4363672417> ?p ?o ?g. }

• W4363672417 endingPage "64" @default.
• W4363672417 startingPage "54" @default.
• W4363672417 abstract "Approximately 20%-50% of patients with large B-cell lymphoma (LBCL) experience poor outcomes. We aimed to evaluate the combined prognostic value of circulating tumour DNA (ctDNA) and total metabolic tumour volume (TMTV) in LBCL. This observational single-centre study included 112 newly diagnosed LBCL patients, receiving R-CHOP/R-CHOP-like chemotherapies. CtDNA load was calculated following next-generation sequencing of cell-free DNA (cfDNA) using a targeted 40-gene lymphopanel. TMTV was measured using a fully automated artificial intelligence-based method for lymphoma lesion segmentation. CtDNA was detected in cfDNA samples from 95 patients with a median concentration of 3.15 log haploid genome equivalents per mL. TMTV measurements were available for 102 patients. The median TMTV was 501 mL. High ctDNA load (>3.57 log hGE/mL) or high TMTV (>200 mL) were associated with shorter 1-year PFS (44% vs. 83%, p < 0.001 and 64% vs. 97%, p = 0.002, respectively). When combined, three prognostic groups were identified. The shortest PFS was observed when both TMTV and ctDNA load were high (p < 0.001). Even with a short follow up, combining ctDNA load with TMTV improved the risk stratification of patients with aggressive LBCL. In the near future, very high-risk patients could benefit from CAR T-cell therapy or bispecific antibodies as first-line treatments." @default.
• W4363672417 created "2023-04-11" @default.
• W4363672417 creator A5002997425 @default.
• W4363672417 creator A5012900514 @default.
• W4363672417 creator A5016572439 @default.
• W4363672417 creator A5018129015 @default.
• W4363672417 creator A5020864657 @default.
• W4363672417 creator A5031041032 @default.
• W4363672417 creator A5032732747 @default.
• W4363672417 creator A5037590260 @default.
• W4363672417 creator A5049272364 @default.
• W4363672417 creator A5052637705 @default.
• W4363672417 creator A5067159804 @default.
• W4363672417 creator A5069778666 @default.
• W4363672417 creator A5070939063 @default.
• W4363672417 creator A5073135494 @default.
• W4363672417 creator A5078528053 @default.
• W4363672417 creator A5082008098 @default.
• W4363672417 creator A5085259120 @default.
• W4363672417 creator A5086219277 @default.
• W4363672417 date "2023-04-10" @default.
• W4363672417 modified "2023-10-18" @default.
• W4363672417 title "Baseline circulating tumour <scp>DNA</scp> and total metabolic tumour volume as early outcome predictors in aggressive large B‐cell lymphoma. A real‐world 112‐patient cohort" @default.
• W4363672417 cites W1972232210 @default.
• W4363672417 cites W1976564639 @default.
• W4363672417 cites W2018071905 @default.
• W4363672417 cites W2027735722 @default.
• W4363672417 cites W2037796411 @default.
• W4363672417 cites W2051650384 @default.
• W4363672417 cites W2057239580 @default.
• W4363672417 cites W2063691874 @default.
• W4363672417 cites W2072351874 @default.
• W4363672417 cites W2075627595 @default.
• W4363672417 cites W2119147717 @default.
• W4363672417 cites W2123872027 @default.
• W4363672417 cites W2131900456 @default.
• W4363672417 cites W2133650808 @default.
• W4363672417 cites W2136268782 @default.
• W4363672417 cites W2137816642 @default.
• W4363672417 cites W2139047632 @default.
• W4363672417 cites W2147246240 @default.
• W4363672417 cites W2154019042 @default.
• W4363672417 cites W2158267770 @default.
• W4363672417 cites W2164225457 @default.
• W4363672417 cites W2216659987 @default.
• W4363672417 cites W2282026400 @default.
• W4363672417 cites W2291210741 @default.
• W4363672417 cites W2310716991 @default.
• W4363672417 cites W2334417343 @default.
• W4363672417 cites W2336746732 @default.
• W4363672417 cites W2462981464 @default.
• W4363672417 cites W2551589138 @default.
• W4363672417 cites W2579884965 @default.
• W4363672417 cites W2614435853 @default.
• W4363672417 cites W2744261860 @default.
• W4363672417 cites W2788380546 @default.
• W4363672417 cites W2796652121 @default.
• W4363672417 cites W2801763724 @default.
• W4363672417 cites W2887392092 @default.
• W4363672417 cites W2888203943 @default.
• W4363672417 cites W2927995861 @default.
• W4363672417 cites W2972566401 @default.
• W4363672417 cites W3002263815 @default.
• W4363672417 cites W3016044607 @default.
• W4363672417 cites W3093550081 @default.
• W4363672417 cites W3094714228 @default.
• W4363672417 cites W3097004036 @default.
• W4363672417 cites W3134205746 @default.
• W4363672417 cites W4205736005 @default.
• W4363672417 doi "https://doi.org/10.1111/bjh.18809" @default.
• W4363672417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37038217" @default.
• W4363672417 hasPublicationYear "2023" @default.
• W4363672417 type Work @default.
• W4363672417 citedByCount "1" @default.
• W4363672417 countsByYear W43636724172023 @default.
• W4363672417 crossrefType "journal-article" @default.
• W4363672417 hasAuthorship W4363672417A5002997425 @default.
• W4363672417 hasAuthorship W4363672417A5012900514 @default.
• W4363672417 hasAuthorship W4363672417A5016572439 @default.
• W4363672417 hasAuthorship W4363672417A5018129015 @default.
• W4363672417 hasAuthorship W4363672417A5020864657 @default.
• W4363672417 hasAuthorship W4363672417A5031041032 @default.
• W4363672417 hasAuthorship W4363672417A5032732747 @default.
• W4363672417 hasAuthorship W4363672417A5037590260 @default.
• W4363672417 hasAuthorship W4363672417A5049272364 @default.
• W4363672417 hasAuthorship W4363672417A5052637705 @default.
• W4363672417 hasAuthorship W4363672417A5067159804 @default.
• W4363672417 hasAuthorship W4363672417A5069778666 @default.
• W4363672417 hasAuthorship W4363672417A5070939063 @default.
• W4363672417 hasAuthorship W4363672417A5073135494 @default.
• W4363672417 hasAuthorship W4363672417A5078528053 @default.
• W4363672417 hasAuthorship W4363672417A5082008098 @default.
• W4363672417 hasAuthorship W4363672417A5085259120 @default.
• W4363672417 hasAuthorship W4363672417A5086219277 @default.
• W4363672417 hasBestOaLocation W43636724171 @default.
• W4363672417 hasConcept C126322002 @default.
• W4363672417 hasConcept C126894567 @default.
• W4363672417 hasConcept C143998085 @default.

• next