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• W4363673437 abstract "Hexafluoroisopropanol (HFIP) is an important intermediate of sevoflurane, an inhalation anesthetic for pediatric anesthesia, and it is produced industrially mainly by the catalytic hydrogenation reduction of hexafluoroacetone (HFA). In previous studies, the hydrogenation of HFA was usually performed in batch reactors with the disadvantages of harsh reaction conditions and low conversion rates. On the other hand, continuous flow technology is increasingly being used for intrinsically safe hydrogenation processes to avoid safety issues caused by the accumulation of hydrogen gas in high-pressure reactors. In this study, a continuous flow system was developed in a micropacked-bed reactor, and the intrinsic kinetics of the reaction were studied. This continuous flow process minimized mass and heat transfer problems and achieved higher productivity in terms of time and space yield than traditional process methods. Under kinetically controlled conditions, the operating conditions were varied with temperature between 363 and 393 K, hydrogen pressure of 10 bar, and catalyst loading between 0.1 and 0.5 g. In the end, we achieved conversion and selectivity of up to 99% and a space–time yield of about 9 times that of the batch reactor. To further investigate the long-term stability of the reaction system, the flow system was successfully operated for 90 h at a liquid flow rate of 0.5 mL/min. In addition, residence time distribution curves at different flow rates were determined, and possible mechanistic pathways of the reaction were explored based on the Langmuir–Hinshelwood method. The reaction was found to be an adsorption–desorption type with a mechanism of competitive adsorption by H2 dissociation, and the thermodynamic properties associated with the rate constants were estimated." @default.
• W4363673437 created "2023-04-11" @default.
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• W4363673437 date "2023-04-10" @default.
• W4363673437 modified "2023-09-23" @default.
• W4363673437 title "Heterogeneous Continuous Flow Hydrogenation of Hexafluoroacetone Trihydrate and Its Kinetic Modeling" @default.
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• W4363673437 doi "https://doi.org/10.1021/acs.iecr.3c00291" @default.
• W4363673437 hasPublicationYear "2023" @default.
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