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• W4363676217 abstract "As the population ages, dementia has become an urgent threat to public health. Alzheimer’s disease (AD), the major form of dementia, is becoming a leading contributor to the global burden of disease ( 1 Livingston G. Huntley J. Sommerlad A. Ames D. Ballard C. Banerjee S. et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020; 396: 413-446 Abstract Full Text Full Text PDF PubMed Scopus (2689) Google Scholar ). There is currently no cure for AD, and reducing the incidence of AD by managing modifiable risk factors might be an effective and preventive approach ( 2 Stephan B.C.M. Siervo M. Brayne C. How can population-based studies best be utilized to reduce the global impact of dementia? Recommendations for researchers, funders, and policymakers. Alzheimers Dement. 2020; 16: 1448-1456 Crossref PubMed Scopus (12) Google Scholar ). The identification of reliable risk factors is thus a fundamental step for the prevention of AD. AD was proposed to be a complex syndrome involving dozens of endogenous and exogenous risk factors or exposures, which as a whole was defined as the exposome ( 3 Finch C.E. Kulminski A.M. The Alzheimer’s disease exposome. Alzheimers Dement. 2019; 15: 1123-1132 Crossref PubMed Scopus (40) Google Scholar ). While observational epidemiologic studies have suggested quite a few risk factors for AD, for instance less education, hypertension, and depression ( 1 Livingston G. Huntley J. Sommerlad A. Ames D. Ballard C. Banerjee S. et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020; 396: 413-446 Abstract Full Text Full Text PDF PubMed Scopus (2689) Google Scholar ), several issues remained to be clarified. Are there any additional risk factors remaining to be identified? Do the recognized risk factors causally associate with AD? How do the modifiable risk factors contribute to the disease? The emergence of large-scale biobank resources, with comprehensive genomic and phenomic data, together with elegant data-mining algorithms, provide the opportunity to solve these questions. SEE CORRESPONDING ARTICLE ON PAGE 790 SEE CORRESPONDING ARTICLE ON PAGE 790 A Phenome-wide Association and Mendelian Randomization Study for Alzheimer’s Disease: A Prospective Cohort Study of 502,493 Participants From the UK BiobankBiological PsychiatryVol. 93Issue 9PreviewConsiderable uncertainty remains regarding associations of multiple risk factors with Alzheimer’s disease (AD). We aimed to systematically screen and validate a wide range of potential risk factors for AD. Full-Text PDF" @default.
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• W4363676217 date "2023-05-01" @default.
• W4363676217 modified "2023-10-14" @default.
• W4363676217 title "Toward a Full Understanding of Causal and Modifiable Risk Factors for Alzheimer’s Disease by Integrative Phenome-wide Association Studies" @default.
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• W4363676217 doi "https://doi.org/10.1016/j.biopsych.2023.01.011" @default.
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