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- W4363676647 abstract "Abstract Background We explored the relative clinical efficacy of intensity-modulated radiation therapy (IMRT) in the treatment of patients with oropharyngeal cancer (OPC) compared with three-dimensional conformal radiation therapy (3D-CRT). Particular attention was paid to osteoradionecrosis (ORN). Materials and methods Seventy-four OPC patients treated with definitive IMRT or 3D-CRT between May 2010 and December 2018 were analyzed. Of these, 42 patients were treated with IMRT and 32 with 3D-CRT. We compared clinical benefits. In particular, we focused on ORN, and evaluated the irradiated mandibular volumes. Results Late Grade 2 xerostomia was detected in 6 (19.4%) and 15 patients (71.4%) in the IMRT and 3D-CRT groups, respectively (P = 0.003). Five patients had Grade 2–3 ORN in the 3D-CRT group. In contrast, no ORN was observed in the IMRT group. A comparison of the mandible volumes between the two groups showed that the IMRT group had lower mandibular volumes than the 3D-CRT group in the high-dose range of V40, V50, V60 and V70. In addition, a comparison of the mandibular volumes between ORN and non-ORN showed a significant difference in the V60 and V70. ORN incidence was higher in V60 ≥ 25% and V70 ≥ 15%. Conclusion On comparing IMRT with 3D-CRT, the advantages of IMRT translated into a significant reduction of late xerostomia and ORN in patients with OPC. Reducing of the mandibular V60 and V70 values by IMRT seemed to reduce the risk of ORN." @default.
- W4363676647 created "2023-04-11" @default.
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- W4363676647 date "2023-04-10" @default.
- W4363676647 modified "2023-10-10" @default.
- W4363676647 title "Clinical efficacy of intensity-modulated radiation therapy in patients with oropharyngeal carcinoma: a comparison with three-dimensional conformal radiation therapy with a focus on osteoradionecrosis" @default.
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- W4363676647 doi "https://doi.org/10.21203/rs.3.rs-2585140/v1" @default.
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