Matches in SemOpenAlex for { <https://semopenalex.org/work/W4363679587> ?p ?o ?g. }
- W4363679587 endingPage "1196" @default.
- W4363679587 startingPage "1196" @default.
- W4363679587 abstract "This study aimed to develop an effective treatment for diabetes and diabetic complications, based on the advantage complementary strategy of drug-drug salt, by designing and synthesizing the multicomponent molecular salts containing metformin (MET) and rhein (RHE). Finally, the salts of MET-RHE (1:1), MET-RHE-H2O (1:1:1), MET-RHE-ethanol-H2O (1:1:1:1), and MET-RHE-acetonitrile (2:2:1) were obtained, indicating the polymorphism of salts formed by MET and RHE. The structures were analyzed by the combination of characterization experiments and theoretical calculation, and the formation mechanism of polymorphism was discussed. The obtained results of in vitro evaluation showed that MET-RHE had a similar hygroscopicity with metformin hydrochloride (MET·HCl), and the solubility of the component of RHE increased by approximately 93 times, which laid a foundation for improving the bioavailability of MET and RHE in vivo. The evaluation of hypoglycemic activity in mice (C57BL/6N) indicated that MET-RHE exhibited better hypoglycemic activity than the parent drugs and the physical mixtures of MET and RHE. The above findings demonstrate that this study achieved the complementary advantages of MET and RHE through the multicomponent pharmaceutical salification technique, and provides new possibilities for the treatment of diabetic complications." @default.
- W4363679587 created "2023-04-11" @default.
- W4363679587 creator A5009303632 @default.
- W4363679587 creator A5009377338 @default.
- W4363679587 creator A5012493087 @default.
- W4363679587 creator A5026111925 @default.
- W4363679587 creator A5033681865 @default.
- W4363679587 creator A5054406851 @default.
- W4363679587 creator A5056709272 @default.
- W4363679587 creator A5063615774 @default.
- W4363679587 creator A5066716873 @default.
- W4363679587 creator A5068899498 @default.
- W4363679587 creator A5074411641 @default.
- W4363679587 creator A5091598985 @default.
- W4363679587 date "2023-04-09" @default.
- W4363679587 modified "2023-10-18" @default.
- W4363679587 title "Versatile Solid Modifications of Multicomponent Pharmaceutical Salts: Novel Metformin–Rhein Salts Based on Advantage Complementary Strategy Design" @default.
- W4363679587 cites W1559960574 @default.
- W4363679587 cites W1966136073 @default.
- W4363679587 cites W1978690582 @default.
- W4363679587 cites W1978873740 @default.
- W4363679587 cites W1982294266 @default.
- W4363679587 cites W1996854381 @default.
- W4363679587 cites W1996888759 @default.
- W4363679587 cites W2000685217 @default.
- W4363679587 cites W2001454290 @default.
- W4363679587 cites W2005812743 @default.
- W4363679587 cites W2007068142 @default.
- W4363679587 cites W2011134011 @default.
- W4363679587 cites W2020722862 @default.
- W4363679587 cites W2037767059 @default.
- W4363679587 cites W2039583649 @default.
- W4363679587 cites W2045883983 @default.
- W4363679587 cites W2048483115 @default.
- W4363679587 cites W2060064411 @default.
- W4363679587 cites W2062219407 @default.
- W4363679587 cites W2067856270 @default.
- W4363679587 cites W2088113192 @default.
- W4363679587 cites W2091257276 @default.
- W4363679587 cites W2097668381 @default.
- W4363679587 cites W2102493638 @default.
- W4363679587 cites W2118643243 @default.
- W4363679587 cites W2119343768 @default.
- W4363679587 cites W2128367294 @default.
- W4363679587 cites W2132525235 @default.
- W4363679587 cites W2136122793 @default.
- W4363679587 cites W2136386001 @default.
- W4363679587 cites W2140132655 @default.
- W4363679587 cites W2144210760 @default.
- W4363679587 cites W2148509846 @default.
- W4363679587 cites W2160088494 @default.
- W4363679587 cites W2162039295 @default.
- W4363679587 cites W2165202903 @default.
- W4363679587 cites W2181174026 @default.
- W4363679587 cites W2260080015 @default.
- W4363679587 cites W2291385518 @default.
- W4363679587 cites W2416123422 @default.
- W4363679587 cites W2419958562 @default.
- W4363679587 cites W2462341956 @default.
- W4363679587 cites W2484356835 @default.
- W4363679587 cites W2528573427 @default.
- W4363679587 cites W2546999199 @default.
- W4363679587 cites W2559968683 @default.
- W4363679587 cites W2569597596 @default.
- W4363679587 cites W2606697308 @default.
- W4363679587 cites W2731568958 @default.
- W4363679587 cites W2745683633 @default.
- W4363679587 cites W2764154140 @default.
- W4363679587 cites W2789732774 @default.
- W4363679587 cites W2883347551 @default.
- W4363679587 cites W2889747490 @default.
- W4363679587 cites W2890776339 @default.
- W4363679587 cites W2902785607 @default.
- W4363679587 cites W2968968752 @default.
- W4363679587 cites W2972145382 @default.
- W4363679587 cites W2980430294 @default.
- W4363679587 cites W2999756934 @default.
- W4363679587 cites W3011715616 @default.
- W4363679587 cites W3034118722 @default.
- W4363679587 cites W3049383953 @default.
- W4363679587 cites W3087824192 @default.
- W4363679587 cites W3095473814 @default.
- W4363679587 cites W3096649194 @default.
- W4363679587 cites W3120344776 @default.
- W4363679587 cites W3134052169 @default.
- W4363679587 cites W3209247205 @default.
- W4363679587 cites W4205859621 @default.
- W4363679587 cites W4213434480 @default.
- W4363679587 cites W4285109569 @default.
- W4363679587 cites W4285187830 @default.
- W4363679587 cites W2901638639 @default.
- W4363679587 doi "https://doi.org/10.3390/pharmaceutics15041196" @default.
- W4363679587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37111681" @default.
- W4363679587 hasPublicationYear "2023" @default.
- W4363679587 type Work @default.
- W4363679587 citedByCount "0" @default.
- W4363679587 crossrefType "journal-article" @default.
- W4363679587 hasAuthorship W4363679587A5009303632 @default.