Matches in SemOpenAlex for { <https://semopenalex.org/work/W4364360091> ?p ?o ?g. }
- W4364360091 abstract "Cancer progression and metastasis due to tumor immune evasion and drug resistance is strongly associated with immune suppressive cellular responses, particularly in the case of metastatic tumors. The myeloid cell component plays a key role within the tumor microenvironment (TME) and disrupts both adaptive and innate immune cell responses leading to loss of tumor control. Therefore, strategies to eliminate or modulate the myeloid cell compartment of the TME are increasingly attractive to non-specifically increase anti-tumoral immunity and enhance existing immunotherapies. This review covers current strategies targeting myeloid suppressor cells in the TME to enhance anti-tumoral immunity, including strategies that target chemokine receptors to deplete selected immune suppressive myeloid cells and relieve the inhibition imposed on the effector arms of adaptive immunity. Remodeling the TME can in turn improve the activity of other immunotherapies such as checkpoint blockade and adoptive T cell therapies in immunologically “cold” tumors. When possible, in this review, we have provided evidence and outcomes from recent or current clinical trials evaluating the effectiveness of the specific strategies used to target myeloid cells in the TME. The review seeks to provide a broad overview of how myeloid cell targeting can become a key foundational approach to an overall strategy for improving tumor responses to immunotherapy." @default.
- W4364360091 created "2023-04-12" @default.
- W4364360091 creator A5053589592 @default.
- W4364360091 creator A5083005720 @default.
- W4364360091 creator A5088431874 @default.
- W4364360091 date "2023-04-11" @default.
- W4364360091 modified "2023-10-18" @default.
- W4364360091 title "Strategies to overcome myeloid cell induced immune suppression in the tumor microenvironment" @default.
- W4364360091 cites W1438161774 @default.
- W4364360091 cites W1480357432 @default.
- W4364360091 cites W1540592014 @default.
- W4364360091 cites W1560466618 @default.
- W4364360091 cites W1881610795 @default.
- W4364360091 cites W1925817305 @default.
- W4364360091 cites W1971837077 @default.
- W4364360091 cites W1974903851 @default.
- W4364360091 cites W1980584100 @default.
- W4364360091 cites W1982859282 @default.
- W4364360091 cites W1984329684 @default.
- W4364360091 cites W1984550821 @default.
- W4364360091 cites W1987446429 @default.
- W4364360091 cites W1993604578 @default.
- W4364360091 cites W1996998764 @default.
- W4364360091 cites W2000959092 @default.
- W4364360091 cites W2001717792 @default.
- W4364360091 cites W2002157461 @default.
- W4364360091 cites W2003603044 @default.
- W4364360091 cites W2012396536 @default.
- W4364360091 cites W2024725966 @default.
- W4364360091 cites W2028166635 @default.
- W4364360091 cites W2029507589 @default.
- W4364360091 cites W2030887834 @default.
- W4364360091 cites W2032021351 @default.
- W4364360091 cites W2037957813 @default.
- W4364360091 cites W2039008119 @default.
- W4364360091 cites W2043046186 @default.
- W4364360091 cites W2043812762 @default.
- W4364360091 cites W2047104532 @default.
- W4364360091 cites W2049873925 @default.
- W4364360091 cites W2050618841 @default.
- W4364360091 cites W2055284977 @default.
- W4364360091 cites W2058887247 @default.
- W4364360091 cites W2060672294 @default.
- W4364360091 cites W2063264144 @default.
- W4364360091 cites W2063874265 @default.
- W4364360091 cites W2064989764 @default.
- W4364360091 cites W2066255007 @default.
- W4364360091 cites W2071959986 @default.
- W4364360091 cites W2076743146 @default.
- W4364360091 cites W2086834665 @default.
- W4364360091 cites W2088277062 @default.
- W4364360091 cites W2090698350 @default.
- W4364360091 cites W2094269270 @default.
- W4364360091 cites W2095808484 @default.
- W4364360091 cites W2096616470 @default.
- W4364360091 cites W2103079055 @default.
- W4364360091 cites W2104065243 @default.
- W4364360091 cites W2107398170 @default.
- W4364360091 cites W2107567947 @default.
- W4364360091 cites W2112057120 @default.
- W4364360091 cites W2113855026 @default.
- W4364360091 cites W2115736737 @default.
- W4364360091 cites W2116556497 @default.
- W4364360091 cites W2123127261 @default.
- W4364360091 cites W2127079528 @default.
- W4364360091 cites W2127853804 @default.
- W4364360091 cites W2130870648 @default.
- W4364360091 cites W2138281334 @default.
- W4364360091 cites W2143455089 @default.
- W4364360091 cites W2149067734 @default.
- W4364360091 cites W2150544967 @default.
- W4364360091 cites W2150885920 @default.
- W4364360091 cites W2152677909 @default.
- W4364360091 cites W2154887208 @default.
- W4364360091 cites W2155360682 @default.
- W4364360091 cites W2157096396 @default.
- W4364360091 cites W2159803625 @default.
- W4364360091 cites W2159999569 @default.
- W4364360091 cites W2164721179 @default.
- W4364360091 cites W2166932124 @default.
- W4364360091 cites W2168030213 @default.
- W4364360091 cites W2171437874 @default.
- W4364360091 cites W2213790033 @default.
- W4364360091 cites W2232660545 @default.
- W4364360091 cites W2312561529 @default.
- W4364360091 cites W2313998192 @default.
- W4364360091 cites W2344013086 @default.
- W4364360091 cites W2400338166 @default.
- W4364360091 cites W2416038770 @default.
- W4364360091 cites W2471500324 @default.
- W4364360091 cites W2472847191 @default.
- W4364360091 cites W2509768156 @default.
- W4364360091 cites W2527564493 @default.
- W4364360091 cites W2530152170 @default.
- W4364360091 cites W2535549547 @default.
- W4364360091 cites W2574778237 @default.
- W4364360091 cites W2576928311 @default.
- W4364360091 cites W2579947724 @default.
- W4364360091 cites W2589308094 @default.
- W4364360091 cites W2591937746 @default.