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- W4364361400 abstract "PNO1 (Dim2 or Rrp2 or YOR145), a highly conserved regulator of ribosome assembly from yeast to mammals, is involved in forming the 90S pre-ribosome and plays an essential role in the late stage of 40S small subunit maturation. Recent studies have found that PNO1 is involved in the progression of a variety of tumors and is highly expressed in colorectal, lung, esophageal, glioma, and breast cancer and is associated with poor prognosis. In tumors, PNO1 mainly promotes cell proliferation, invasion, and autophagy and inhibits apoptosis by regulating the P53 pathway, FAK/AKT pathway, Notch signaling pathway, and MAPK signaling pathway. The high expression of PNO1 in various tumors may be reduced by the regulation of early B cell factor 1 (EBF1), transcription factor MYC, miR-340-5p, and the drug celecoxib inhibiting tumor proliferation, invasion and migration, and autophagy, promoting apoptosis. This article reviews the structure and function of PNO1, related molecular pathways, and its regulatory role in tumor formation and discusses its possibility as a molecular target for tumor therapy." @default.
- W4364361400 created "2023-04-12" @default.
- W4364361400 creator A5015179861 @default.
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- W4364361400 date "2023-04-11" @default.
- W4364361400 modified "2023-10-17" @default.
- W4364361400 title "Progress on the role and mechanism of ribosome assembly regulator PNO1 in tumor" @default.
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- W4364361400 doi "https://doi.org/10.1080/26895293.2023.2197160" @default.
- W4364361400 hasPublicationYear "2023" @default.
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