Matches in SemOpenAlex for { <https://semopenalex.org/work/W4364362088> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4364362088 abstract "<div>AbstractPurpose:<p>Claudin-6 (CLDN6) is expressed at elevated levels in multiple human cancers including ovarian and endometrial malignancies, with little or no detectable expression in normal adult tissue. This expression profile makes CLDN6 an ideal target for development of a potential therapeutic antibody–drug conjugate (ADC). This study describes the generation and preclinical characterization of CLDN6–23-ADC, an ADC consisting of a humanized anti-CLDN6 monoclonal antibody coupled to monomethyl auristatin E (MMAE) via a cleavable linker.</p>Experimental Design:<p>A fully humanized anti-CLDN6 antibody was conjugated to MMAE resulting in the potential therapeutic ADC, CLDN6–23-ADC. The antitumor efficacy of CLDN6–23-ADC was assessed for antitumor efficacy in CLDN6-positive (CLDN6+) and -negative (CLDN6−) xenografts and patient-derived xenograft (PDX) models of human cancers.</p>Results:<p>CLDN6–23-ADC selectively binds to CLDN6, versus other CLDN family members, inhibits the proliferation of CLDN6+ cancer cells <i>in vitro</i>, and is rapidly internalized in CLDN6+ cells. Robust tumor regressions were observed in multiple CLDN6+ xenograft models and tumor inhibition led to markedly enhanced survival of CLDN6+ PDX tumors following treatment with CLDN6–23-ADC. IHC assessment of cancer tissue microarrays demonstrate elevated levels of CLDN6 in 29% of ovarian epithelial carcinomas. Approximately 45% of high-grade serous ovarian carcinomas and 11% of endometrial carcinomas are positive for the target.</p>Conclusions:<p>We report the development of a novel ADC, CLDN6–23-ADC, that selectively targets CLDN6, a potential onco-fetal-antigen which is highly expressed in ovarian and endometrial cancers. CLDN6–23-ADC exhibits robust tumor regressions in mouse models of human ovarian and endometrial cancers and is currently undergoing phase I study.</p></div>" @default.
- W4364362088 created "2023-04-12" @default.
- W4364362088 creator A5000509598 @default.
- W4364362088 creator A5002335972 @default.
- W4364362088 creator A5009051030 @default.
- W4364362088 creator A5010670943 @default.
- W4364362088 creator A5013404372 @default.
- W4364362088 creator A5015491002 @default.
- W4364362088 creator A5019314293 @default.
- W4364362088 creator A5021579982 @default.
- W4364362088 creator A5028010756 @default.
- W4364362088 creator A5033519049 @default.
- W4364362088 creator A5043845770 @default.
- W4364362088 creator A5044485794 @default.
- W4364362088 creator A5050625719 @default.
- W4364362088 creator A5058453547 @default.
- W4364362088 creator A5060129827 @default.
- W4364362088 creator A5062082536 @default.
- W4364362088 creator A5063951168 @default.
- W4364362088 creator A5070780127 @default.
- W4364362088 creator A5078207096 @default.
- W4364362088 creator A5080006341 @default.
- W4364362088 date "2023-04-11" @default.
- W4364362088 modified "2023-10-16" @default.
- W4364362088 title "Data from Preclinical Efficacy of the Antibody–Drug Conjugate CLDN6–23-ADC for the Treatment of CLDN6-Positive Solid Tumors" @default.
- W4364362088 doi "https://doi.org/10.1158/1078-0432.c.6571949.v1" @default.
- W4364362088 hasPublicationYear "2023" @default.
- W4364362088 type Work @default.
- W4364362088 citedByCount "0" @default.
- W4364362088 crossrefType "posted-content" @default.
- W4364362088 hasAuthorship W4364362088A5000509598 @default.
- W4364362088 hasAuthorship W4364362088A5002335972 @default.
- W4364362088 hasAuthorship W4364362088A5009051030 @default.
- W4364362088 hasAuthorship W4364362088A5010670943 @default.
- W4364362088 hasAuthorship W4364362088A5013404372 @default.
- W4364362088 hasAuthorship W4364362088A5015491002 @default.
- W4364362088 hasAuthorship W4364362088A5019314293 @default.
- W4364362088 hasAuthorship W4364362088A5021579982 @default.
- W4364362088 hasAuthorship W4364362088A5028010756 @default.
- W4364362088 hasAuthorship W4364362088A5033519049 @default.
- W4364362088 hasAuthorship W4364362088A5043845770 @default.
- W4364362088 hasAuthorship W4364362088A5044485794 @default.
- W4364362088 hasAuthorship W4364362088A5050625719 @default.
- W4364362088 hasAuthorship W4364362088A5058453547 @default.
- W4364362088 hasAuthorship W4364362088A5060129827 @default.
- W4364362088 hasAuthorship W4364362088A5062082536 @default.
- W4364362088 hasAuthorship W4364362088A5063951168 @default.
- W4364362088 hasAuthorship W4364362088A5070780127 @default.
- W4364362088 hasAuthorship W4364362088A5078207096 @default.
- W4364362088 hasAuthorship W4364362088A5080006341 @default.
- W4364362088 hasBestOaLocation W43643620882 @default.
- W4364362088 hasConcept C121608353 @default.
- W4364362088 hasConcept C126322002 @default.
- W4364362088 hasConcept C159654299 @default.
- W4364362088 hasConcept C177779419 @default.
- W4364362088 hasConcept C203014093 @default.
- W4364362088 hasConcept C204232928 @default.
- W4364362088 hasConcept C2777092746 @default.
- W4364362088 hasConcept C2777325958 @default.
- W4364362088 hasConcept C2780427987 @default.
- W4364362088 hasConcept C502942594 @default.
- W4364362088 hasConcept C51872919 @default.
- W4364362088 hasConcept C542903549 @default.
- W4364362088 hasConcept C71924100 @default.
- W4364362088 hasConcept C86803240 @default.
- W4364362088 hasConcept C95444343 @default.
- W4364362088 hasConceptScore W4364362088C121608353 @default.
- W4364362088 hasConceptScore W4364362088C126322002 @default.
- W4364362088 hasConceptScore W4364362088C159654299 @default.
- W4364362088 hasConceptScore W4364362088C177779419 @default.
- W4364362088 hasConceptScore W4364362088C203014093 @default.
- W4364362088 hasConceptScore W4364362088C204232928 @default.
- W4364362088 hasConceptScore W4364362088C2777092746 @default.
- W4364362088 hasConceptScore W4364362088C2777325958 @default.
- W4364362088 hasConceptScore W4364362088C2780427987 @default.
- W4364362088 hasConceptScore W4364362088C502942594 @default.
- W4364362088 hasConceptScore W4364362088C51872919 @default.
- W4364362088 hasConceptScore W4364362088C542903549 @default.
- W4364362088 hasConceptScore W4364362088C71924100 @default.
- W4364362088 hasConceptScore W4364362088C86803240 @default.
- W4364362088 hasConceptScore W4364362088C95444343 @default.
- W4364362088 hasLocation W43643620881 @default.
- W4364362088 hasLocation W43643620882 @default.
- W4364362088 hasOpenAccess W4364362088 @default.
- W4364362088 hasPrimaryLocation W43643620881 @default.
- W4364362088 hasRelatedWork W1138182923 @default.
- W4364362088 hasRelatedWork W1591820460 @default.
- W4364362088 hasRelatedWork W2029763970 @default.
- W4364362088 hasRelatedWork W2055609042 @default.
- W4364362088 hasRelatedWork W2123042378 @default.
- W4364362088 hasRelatedWork W2363885141 @default.
- W4364362088 hasRelatedWork W2374616805 @default.
- W4364362088 hasRelatedWork W2381646249 @default.
- W4364362088 hasRelatedWork W3094600915 @default.
- W4364362088 hasRelatedWork W4211176747 @default.
- W4364362088 isParatext "false" @default.
- W4364362088 isRetracted "false" @default.
- W4364362088 workType "article" @default.