FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4364366034> ?p ?o ?g. }

• W4364366034 abstract "XIAP is a caspase-inhibitory protein that blocks several cell death pathways, and mediates proper activation of inflammatory NOD2-RIP2 signaling. XIAP deficiency in patients with inflammatory diseases such as Crohn's disease, or those needing allogeneic hematopoietic cell transplantation, is associated with a worse prognosis. In this study, we show that XIAP absence sensitizes cells and mice to LPS- and TNF-mediated cell death without affecting LPS- or TNF-induced NF-κB and MAPK signaling. In XIAP deficient mice, RIP1 inhibition effectively blocks TNF-stimulated cell death, hypothermia, lethality, cytokine/chemokine release, intestinal tissue damage and granulocyte migration. By contrast, inhibition of the related kinase RIP2 does not affect TNF-stimulated events, suggesting a lack of involvement for the RIP2-NOD2 signaling pathway. Overall, our data indicate that in XIAP's absence RIP1 is a critical component of TNF-mediated inflammation, suggesting that RIP1 inhibition could be an attractive option for patients with XIAP deficiency." @default.
• W4364366034 created "2023-04-12" @default.
• W4364366034 creator A5025125940 @default.
• W4364366034 creator A5031827010 @default.
• W4364366034 creator A5042343242 @default.
• W4364366034 creator A5043472876 @default.
• W4364366034 creator A5048067233 @default.
• W4364366034 creator A5052200283 @default.
• W4364366034 creator A5052621843 @default.
• W4364366034 creator A5056097513 @default.
• W4364366034 creator A5074860986 @default.
• W4364366034 creator A5076332985 @default.
• W4364366034 date "2023-04-11" @default.
• W4364366034 modified "2023-10-06" @default.
• W4364366034 title "XIAP deletion sensitizes mice to TNF-induced and RIP1-mediated death" @default.
• W4364366034 cites W1642457845 @default.
• W4364366034 cites W1857408336 @default.
• W4364366034 cites W1965157206 @default.
• W4364366034 cites W1966928572 @default.
• W4364366034 cites W1988042498 @default.
• W4364366034 cites W2001166572 @default.
• W4364366034 cites W2024446466 @default.
• W4364366034 cites W2033812051 @default.
• W4364366034 cites W2036414872 @default.
• W4364366034 cites W2051265621 @default.
• W4364366034 cites W2075045888 @default.
• W4364366034 cites W2079633740 @default.
• W4364366034 cites W2081745303 @default.
• W4364366034 cites W2091269867 @default.
• W4364366034 cites W2098975407 @default.
• W4364366034 cites W2118300504 @default.
• W4364366034 cites W2123123035 @default.
• W4364366034 cites W2130892977 @default.
• W4364366034 cites W2151372766 @default.
• W4364366034 cites W2164344962 @default.
• W4364366034 cites W2343417001 @default.
• W4364366034 cites W2738117029 @default.
• W4364366034 cites W2786780864 @default.
• W4364366034 cites W2906580590 @default.
• W4364366034 cites W2945990504 @default.
• W4364366034 cites W2973860554 @default.
• W4364366034 cites W2994986743 @default.
• W4364366034 cites W3005070690 @default.
• W4364366034 cites W3038257623 @default.
• W4364366034 cites W3043787135 @default.
• W4364366034 cites W3089871452 @default.
• W4364366034 cites W3208266476 @default.
• W4364366034 cites W3210695461 @default.
• W4364366034 cites W4200084449 @default.
• W4364366034 cites W4282964340 @default.
• W4364366034 doi "https://doi.org/10.1038/s41419-023-05793-1" @default.
• W4364366034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37041175" @default.
• W4364366034 hasPublicationYear "2023" @default.
• W4364366034 type Work @default.
• W4364366034 citedByCount "0" @default.
• W4364366034 crossrefType "journal-article" @default.
• W4364366034 hasAuthorship W4364366034A5025125940 @default.
• W4364366034 hasAuthorship W4364366034A5031827010 @default.
• W4364366034 hasAuthorship W4364366034A5042343242 @default.
• W4364366034 hasAuthorship W4364366034A5043472876 @default.
• W4364366034 hasAuthorship W4364366034A5048067233 @default.
• W4364366034 hasAuthorship W4364366034A5052200283 @default.
• W4364366034 hasAuthorship W4364366034A5052621843 @default.
• W4364366034 hasAuthorship W4364366034A5056097513 @default.
• W4364366034 hasAuthorship W4364366034A5074860986 @default.
• W4364366034 hasAuthorship W4364366034A5076332985 @default.
• W4364366034 hasBestOaLocation W43643660341 @default.
• W4364366034 hasConcept C13373296 @default.
• W4364366034 hasConcept C17991360 @default.
• W4364366034 hasConcept C184235292 @default.
• W4364366034 hasConcept C185592680 @default.
• W4364366034 hasConcept C190283241 @default.
• W4364366034 hasConcept C203014093 @default.
• W4364366034 hasConcept C2776914184 @default.
• W4364366034 hasConcept C2777408456 @default.
• W4364366034 hasConcept C2778690821 @default.
• W4364366034 hasConcept C31573885 @default.
• W4364366034 hasConcept C33195913 @default.
• W4364366034 hasConcept C502942594 @default.
• W4364366034 hasConcept C55493867 @default.
• W4364366034 hasConcept C57074206 @default.
• W4364366034 hasConcept C62478195 @default.
• W4364366034 hasConcept C86803240 @default.
• W4364366034 hasConcept C94030615 @default.
• W4364366034 hasConcept C95444343 @default.
• W4364366034 hasConcept C98424977 @default.
• W4364366034 hasConceptScore W4364366034C13373296 @default.
• W4364366034 hasConceptScore W4364366034C17991360 @default.
• W4364366034 hasConceptScore W4364366034C184235292 @default.
• W4364366034 hasConceptScore W4364366034C185592680 @default.
• W4364366034 hasConceptScore W4364366034C190283241 @default.
• W4364366034 hasConceptScore W4364366034C203014093 @default.
• W4364366034 hasConceptScore W4364366034C2776914184 @default.
• W4364366034 hasConceptScore W4364366034C2777408456 @default.
• W4364366034 hasConceptScore W4364366034C2778690821 @default.
• W4364366034 hasConceptScore W4364366034C31573885 @default.
• W4364366034 hasConceptScore W4364366034C33195913 @default.
• W4364366034 hasConceptScore W4364366034C502942594 @default.
• W4364366034 hasConceptScore W4364366034C55493867 @default.
• W4364366034 hasConceptScore W4364366034C57074206 @default.

• next