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• W4364374224 abstract "ABSTRACT Background Physical activity is strongly protective against the development of chronic diseases associated with aging. We previously demonstrated that digital interventions delivered through a smartphone app can increase short-term physical activity. Our randomized crossover trial has continued to digitally enroll participants, allowing increasing statistical power for greater precision in subsequent analyses. Methods We offered enrollment to adults aged ≥18 years with access to an iPhone and the MyHeart Counts app. After completion of a 1-week baseline period, e-consented participants were randomly allocated to four 7-day interventions. Interventions consisted of: 1) daily personalized e-coaching based on the individual’s baseline activity patterns, 2) daily prompts to complete 10,000 steps, 3) hourly prompts to stand following inactivity, and 4) daily instructions to read guidelines from the American Heart Association website. The trial was completed in a free-living setting, where neither the participants or investigators were blinded to the intervention. The primary outcome was change in mean daily step count from baseline for each of the four interventions, assessed in a modified intention-to-treat analysis. This trial is registered with ClinicalTrials.gov , NCT03090321 . Findings Between January 1, 2017 and April 1, 2022, 4500 participants consented to enroll in the trial, of whom 2458 completed 7-days of baseline monitoring (mean daily steps 4232±73) and at least one day of one of the four interventions. The greater statistical power afforded by continued passive enrollment revealed that e-coaching prompts, tailored to an individual, increased step count significantly more than other interventions (402±71 steps, P= 7.1×10 −8 ). Interpretation Digital studies can continuously recruit participants in a cost-effective manner, allowing for new insights provided by increased statistical power and refinement of prior signals. Here, we show that digital interventions tailored to an individual are effective in increasing short-term physical activity in a free-living cohort. These data suggest that participants are more likely to react positively and increase their physical activity when prompts are personalized. Funding Stanford Data Science Initiative and Catalyst Program, Apple, Google" @default.
• W4364374224 created "2023-04-12" @default.
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• W4364374224 date "2023-04-11" @default.
• W4364374224 modified "2023-10-16" @default.
• W4364374224 title "Personalized digital behavior interventions increase short term physical activity: a randomized control crossover trial substudy of the MyHeart Counts Cardiovascular Health study" @default.
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• W4364374224 doi "https://doi.org/10.1101/2023.04.09.23287650" @default.
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