FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4364374312> ?p ?o ?g. }

• W4364374312 endingPage "113601" @default.
• W4364374312 startingPage "113601" @default.
• W4364374312 abstract "ORP8 has been reported to suppress tumor progression in various malignancies. However, the functions and underlying mechanisms of ORP8 are still unknown in renal cell carcinoma (RCC). Here, decreased expression of ORP8 was detected in RCC tissues and cell lines. Functional assays verified that ORP8 suppressed RCC cell growth, migration, invasion, and metastasis. Mechanistically, ORP8 attenuated Stathmin1 expression by accelerating ubiquitin-mediated proteasomal degradation and led to an increase in microtubule polymerization. Lastly, ORP8 knockdown partly rescued microtubule polymerization, as well as aggressive cell phenotypes induced by paclitaxel. Our findings elucidated that ORP8 suppressed the malignant progression of RCC by increasing Stathmin1 degradation and microtubule polymerization, thus suggesting that ORP8 might be a novel target for the treatment of RCC." @default.
• W4364374312 created "2023-04-12" @default.
• W4364374312 creator A5006567706 @default.
• W4364374312 creator A5021541475 @default.
• W4364374312 creator A5022379761 @default.
• W4364374312 creator A5027163111 @default.
• W4364374312 creator A5028408541 @default.
• W4364374312 creator A5029360035 @default.
• W4364374312 creator A5036622666 @default.
• W4364374312 creator A5046824756 @default.
• W4364374312 creator A5054571236 @default.
• W4364374312 creator A5075139591 @default.
• W4364374312 date "2023-06-01" @default.
• W4364374312 modified "2023-09-28" @default.
• W4364374312 title "ORP8 inhibits renal cell carcinoma progression by accelerating Stathmin1 degradation and microtubule polymerization" @default.
• W4364374312 cites W1563184306 @default.
• W4364374312 cites W1630762356 @default.
• W4364374312 cites W1982645312 @default.
• W4364374312 cites W2000392885 @default.
• W4364374312 cites W2022850721 @default.
• W4364374312 cites W2023078387 @default.
• W4364374312 cites W2024389973 @default.
• W4364374312 cites W2030161403 @default.
• W4364374312 cites W2075962801 @default.
• W4364374312 cites W2086106600 @default.
• W4364374312 cites W2325205961 @default.
• W4364374312 cites W2343801220 @default.
• W4364374312 cites W2424047943 @default.
• W4364374312 cites W2526361828 @default.
• W4364374312 cites W2598734650 @default.
• W4364374312 cites W2601744827 @default.
• W4364374312 cites W2736445678 @default.
• W4364374312 cites W2738395055 @default.
• W4364374312 cites W2757487320 @default.
• W4364374312 cites W2774930654 @default.
• W4364374312 cites W2791859663 @default.
• W4364374312 cites W2792387716 @default.
• W4364374312 cites W2889646458 @default.
• W4364374312 cites W2890251081 @default.
• W4364374312 cites W2937996556 @default.
• W4364374312 cites W3083155301 @default.
• W4364374312 cites W3128995504 @default.
• W4364374312 cites W3200292279 @default.
• W4364374312 doi "https://doi.org/10.1016/j.yexcr.2023.113601" @default.
• W4364374312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37054771" @default.
• W4364374312 hasPublicationYear "2023" @default.
• W4364374312 type Work @default.
• W4364374312 citedByCount "0" @default.
• W4364374312 crossrefType "journal-article" @default.
• W4364374312 hasAuthorship W4364374312A5006567706 @default.
• W4364374312 hasAuthorship W4364374312A5021541475 @default.
• W4364374312 hasAuthorship W4364374312A5022379761 @default.
• W4364374312 hasAuthorship W4364374312A5027163111 @default.
• W4364374312 hasAuthorship W4364374312A5028408541 @default.
• W4364374312 hasAuthorship W4364374312A5029360035 @default.
• W4364374312 hasAuthorship W4364374312A5036622666 @default.
• W4364374312 hasAuthorship W4364374312A5046824756 @default.
• W4364374312 hasAuthorship W4364374312A5054571236 @default.
• W4364374312 hasAuthorship W4364374312A5075139591 @default.
• W4364374312 hasConcept C121608353 @default.
• W4364374312 hasConcept C142724271 @default.
• W4364374312 hasConcept C1491633281 @default.
• W4364374312 hasConcept C173396325 @default.
• W4364374312 hasConcept C20418707 @default.
• W4364374312 hasConcept C2777292972 @default.
• W4364374312 hasConcept C2777472916 @default.
• W4364374312 hasConcept C2779013556 @default.
• W4364374312 hasConcept C2781278892 @default.
• W4364374312 hasConcept C2909009945 @default.
• W4364374312 hasConcept C502942594 @default.
• W4364374312 hasConcept C54355233 @default.
• W4364374312 hasConcept C55493867 @default.
• W4364374312 hasConcept C62112901 @default.
• W4364374312 hasConcept C71924100 @default.
• W4364374312 hasConcept C81885089 @default.
• W4364374312 hasConcept C84425145 @default.
• W4364374312 hasConcept C86803240 @default.
• W4364374312 hasConcept C95444343 @default.
• W4364374312 hasConceptScore W4364374312C121608353 @default.
• W4364374312 hasConceptScore W4364374312C142724271 @default.
• W4364374312 hasConceptScore W4364374312C1491633281 @default.
• W4364374312 hasConceptScore W4364374312C173396325 @default.
• W4364374312 hasConceptScore W4364374312C20418707 @default.
• W4364374312 hasConceptScore W4364374312C2777292972 @default.
• W4364374312 hasConceptScore W4364374312C2777472916 @default.
• W4364374312 hasConceptScore W4364374312C2779013556 @default.
• W4364374312 hasConceptScore W4364374312C2781278892 @default.
• W4364374312 hasConceptScore W4364374312C2909009945 @default.
• W4364374312 hasConceptScore W4364374312C502942594 @default.
• W4364374312 hasConceptScore W4364374312C54355233 @default.
• W4364374312 hasConceptScore W4364374312C55493867 @default.
• W4364374312 hasConceptScore W4364374312C62112901 @default.
• W4364374312 hasConceptScore W4364374312C71924100 @default.
• W4364374312 hasConceptScore W4364374312C81885089 @default.
• W4364374312 hasConceptScore W4364374312C84425145 @default.
• W4364374312 hasConceptScore W4364374312C86803240 @default.
• W4364374312 hasConceptScore W4364374312C95444343 @default.
• W4364374312 hasIssue "1" @default.

• next