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- W4364375149 abstract "Magnetic resonance imaging (MRI) is a promising non-invasive method to assess cartilage regeneration based on the quantitative relationship between MRI features and concentrations of the major components in the extracellular matrix (ECM). To this end, in vitro experiments are performed to investigate the relationship and reveal the underlying mechanism. A series of collagen (COL) and glycosaminoglycan (GAG) solutions at different concentrations are prepared, and T1 and T2 relaxation times are measured with or without a contrast agent (Gd-DTPA2-) by MRI. Fourier transform infrared spectrometry is also used to measure the contents of biomacromolecule-bound water and other water, allowing theoretical derivation of the relationship between biomacromolecules and the resulting T2 values. It has been revealed that the MRI signal in the biomacromolecule aqueous systems is mainly influenced by the protons in hydrogens of biomacromolecule-bound water, which we divide into inner-bound water and outer-bound water. We have also found that COL results in higher sensitivity of bound water than GAG in T2 mapping. Owing to the charge effect, GAG regulates the penetration of the contrast agent during dialysis and has a more significant effect on T1 values than COL. Considering that COL and GAG are the most abundant biomacromolecules in the cartilage, this study is particularly useful for the real-time MRI-guided assessment of cartilage regeneration. A clinical case is reported as an in vivo demonstration, which is consistent with our in vitro results. The established quantitative relation plays a critical academic role in establishing an international standard ISO/TS24560-1:2022 'Clinical evaluation of regenerative knee articular cartilage using delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and T2 mapping' drafted by us and approved by International Standard Organization." @default.
- W4364375149 created "2023-04-12" @default.
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- W4364375149 date "2023-01-01" @default.
- W4364375149 modified "2023-09-28" @default.
- W4364375149 title "Quantitatively relating magnetic resonance <i>T</i>1 and <i>T</i>2 to glycosaminoglycan and collagen concentrations mediated by penetrated contrast agents and biomacromolecule-bound water" @default.
- W4364375149 cites W1002278183 @default.
- W4364375149 cites W1522438682 @default.
- W4364375149 cites W1964478040 @default.
- W4364375149 cites W1970344638 @default.
- W4364375149 cites W1970857984 @default.
- W4364375149 cites W1971713712 @default.
- W4364375149 cites W1974882876 @default.
- W4364375149 cites W1984318620 @default.
- W4364375149 cites W1985011202 @default.
- W4364375149 cites W1988204378 @default.
- W4364375149 cites W1989529231 @default.
- W4364375149 cites W1991552129 @default.
- W4364375149 cites W1993037460 @default.
- W4364375149 cites W2006024297 @default.
- W4364375149 cites W2007476414 @default.
- W4364375149 cites W2008627304 @default.
- W4364375149 cites W2009213294 @default.
- W4364375149 cites W2010701993 @default.
- W4364375149 cites W2010922742 @default.
- W4364375149 cites W2015838124 @default.
- W4364375149 cites W2016200691 @default.
- W4364375149 cites W2027164607 @default.
- W4364375149 cites W2027247698 @default.
- W4364375149 cites W2031251918 @default.
- W4364375149 cites W2033503179 @default.
- W4364375149 cites W2036180784 @default.
- W4364375149 cites W2037804593 @default.
- W4364375149 cites W2041401385 @default.
- W4364375149 cites W2047803832 @default.
- W4364375149 cites W2054250836 @default.
- W4364375149 cites W2061143012 @default.
- W4364375149 cites W206711978 @default.
- W4364375149 cites W2070161476 @default.
- W4364375149 cites W2070399662 @default.
- W4364375149 cites W2080423736 @default.
- W4364375149 cites W2093421257 @default.
- W4364375149 cites W2096983207 @default.
- W4364375149 cites W2105760428 @default.
- W4364375149 cites W2106427746 @default.
- W4364375149 cites W2108379536 @default.
- W4364375149 cites W2113457553 @default.
- W4364375149 cites W2118817262 @default.
- W4364375149 cites W2120545554 @default.
- W4364375149 cites W2126850116 @default.
- W4364375149 cites W2129083253 @default.
- W4364375149 cites W2132673396 @default.
- W4364375149 cites W2159105945 @default.
- W4364375149 cites W2161204978 @default.
- W4364375149 cites W2165935387 @default.
- W4364375149 cites W2235894342 @default.
- W4364375149 cites W2316822864 @default.
- W4364375149 cites W2336565778 @default.
- W4364375149 cites W2338136427 @default.
- W4364375149 cites W2593159131 @default.
- W4364375149 cites W2796512753 @default.
- W4364375149 cites W2928844353 @default.
- W4364375149 cites W2966398958 @default.
- W4364375149 cites W2990124994 @default.
- W4364375149 cites W3036053451 @default.
- W4364375149 cites W3040504914 @default.
- W4364375149 cites W3082671433 @default.
- W4364375149 cites W3093770127 @default.
- W4364375149 cites W3107067604 @default.
- W4364375149 cites W3107112000 @default.
- W4364375149 cites W3155665441 @default.
- W4364375149 cites W3182825803 @default.
- W4364375149 cites W3193789005 @default.
- W4364375149 cites W3209528546 @default.
- W4364375149 cites W3212851977 @default.
- W4364375149 cites W3213641924 @default.
- W4364375149 cites W4210900214 @default.
- W4364375149 cites W4220872119 @default.
- W4364375149 cites W4221128456 @default.
- W4364375149 cites W4224096124 @default.
- W4364375149 cites W4286697277 @default.
- W4364375149 cites W4289711200 @default.
- W4364375149 cites W4290936221 @default.
- W4364375149 cites W4292542165 @default.
- W4364375149 cites W4294531343 @default.
- W4364375149 cites W4304991307 @default.
- W4364375149 cites W4310696335 @default.
- W4364375149 cites W597290641 @default.
- W4364375149 doi "https://doi.org/10.1093/rb/rbad035" @default.
- W4364375149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37206162" @default.
- W4364375149 hasPublicationYear "2023" @default.