Matches in SemOpenAlex for { <https://semopenalex.org/work/W4364376557> ?p ?o ?g. }
- W4364376557 endingPage "323" @default.
- W4364376557 startingPage "309" @default.
- W4364376557 abstract "Growing evidence demonstrates that cancer-associated fibroblasts (CAF) are responsible for tumor genesis, growth, metastasis, and treatment response. Therefore, targeting these cells may contribute to tumor control. It has been proposed that targeting key molecules and pathways of proliferative functions can be more effective than killing CAFs. In this regard, multicellular aggregates, like spheroids, can be used as human tumor models. Spheroids closely resemble human tumors and mimic many of their features. Microfluidic systems are ideal for cultivation and study of spheroids. These systems can be designed with different biological and synthetic matrices in order to have a more realistic simulation of the tumor microenvironment (TME). In this study, we investigated the effect of all-trans retinoic acid (ATRA) on 3D spheroid invasion of MDA-MB cells exposed to hydrogel matrix derived from CAFs. The number of invasive cells significantly decreased in CAF-ECM hydrogel treated with ATRA (p < 0.05), which indicates that ATRA could be effective for CAFs normalization. This experiment was done using an agarose-alginate microfluidic chip. As compared with common methods, such hydrogel casting is an easier method for chip fabrication and can even reduce costs." @default.
- W4364376557 created "2023-04-12" @default.
- W4364376557 creator A5030719194 @default.
- W4364376557 creator A5044522953 @default.
- W4364376557 creator A5052536297 @default.
- W4364376557 creator A5055166166 @default.
- W4364376557 creator A5063577067 @default.
- W4364376557 creator A5081141209 @default.
- W4364376557 date "2023-04-11" @default.
- W4364376557 modified "2023-09-30" @default.
- W4364376557 title "An agarose-alginate microfluidic device for the study of spheroid invasion, ATRA inhibits CAFs-mediated matrix remodeling" @default.
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- W4364376557 doi "https://doi.org/10.1007/s10616-023-00578-y" @default.