Matches in SemOpenAlex for { <https://semopenalex.org/work/W4364377100> ?p ?o ?g. }
- W4364377100 endingPage "124543" @default.
- W4364377100 startingPage "124543" @default.
- W4364377100 abstract "The high incidence and mortality of colorectal cancer (CRC) and the lack of adequate diagnostic molecules have led to poor treatment outcomes for colorectal cancer, making it particularly important to develop methods to obtain molecular with significant diagnostic effects. Here, we proposed a whole and part study strategy (early-stage colorectal cancer as part and colorectal cancer as whole) to identify specific and co-pathways of change in early-stage and colorectal cancers and to discover the determinants of colorectal cancer development. Metabolite biomarkers discovered in plasma may not necessarily reflect the pathological status of tumor tissue. To explore the determinant biomarkers associated with plasma and tumor tissue in the CRC progression, multi-omics were performed on three phases of biomarker discovery studies (discovery, identification and validation) including 128 plasma metabolomes and 84 tissue transcriptomes. Importantly, we observe that the metabolic levels of oleic acid and FA (18:2) in patients with colorectal cancer were much higher than in healthy people. Finally, biofunctional verification confirmed that oleic acid and FA (18:2) can promote the growth of colorectal cancer tumor cells and be used as plasma biomarkers for early-stage colorectal cancer. We propose a novel research strategy to discover co-pathways and important biomarkers that may be targeted for a potential role in early colorectal cancer, and our work provides a promising tool for the clinical diagnosis of colorectal cancer." @default.
- W4364377100 created "2023-04-12" @default.
- W4364377100 creator A5000703206 @default.
- W4364377100 creator A5010470792 @default.
- W4364377100 creator A5021852002 @default.
- W4364377100 creator A5058587719 @default.
- W4364377100 creator A5058777439 @default.
- W4364377100 creator A5070705465 @default.
- W4364377100 creator A5077094802 @default.
- W4364377100 date "2023-07-01" @default.
- W4364377100 modified "2023-10-02" @default.
- W4364377100 title "A new strategy for searching determinants in colorectal cancer progression through whole-part relationship combined with multi-omics" @default.
- W4364377100 cites W1988055681 @default.
- W4364377100 cites W2023535481 @default.
- W4364377100 cites W2037954452 @default.
- W4364377100 cites W2072145718 @default.
- W4364377100 cites W2077522929 @default.
- W4364377100 cites W2088545470 @default.
- W4364377100 cites W2089533821 @default.
- W4364377100 cites W2114870653 @default.
- W4364377100 cites W2117692326 @default.
- W4364377100 cites W2152032358 @default.
- W4364377100 cites W2510661970 @default.
- W4364377100 cites W2769276186 @default.
- W4364377100 cites W2773498353 @default.
- W4364377100 cites W2787224541 @default.
- W4364377100 cites W2793124274 @default.
- W4364377100 cites W2890074591 @default.
- W4364377100 cites W2919528939 @default.
- W4364377100 cites W2920863623 @default.
- W4364377100 cites W2937012533 @default.
- W4364377100 cites W2938629106 @default.
- W4364377100 cites W2960942904 @default.
- W4364377100 cites W2964245665 @default.
- W4364377100 cites W2997822868 @default.
- W4364377100 cites W3014891010 @default.
- W4364377100 cites W3021363888 @default.
- W4364377100 cites W3034527043 @default.
- W4364377100 cites W3047495915 @default.
- W4364377100 cites W3084161163 @default.
- W4364377100 cites W3089576524 @default.
- W4364377100 cites W3119002141 @default.
- W4364377100 cites W3128646645 @default.
- W4364377100 cites W3128997041 @default.
- W4364377100 cites W3155809151 @default.
- W4364377100 cites W3158219054 @default.
- W4364377100 cites W3214026108 @default.
- W4364377100 cites W4214544275 @default.
- W4364377100 cites W4290621813 @default.
- W4364377100 cites W4292267290 @default.
- W4364377100 doi "https://doi.org/10.1016/j.talanta.2023.124543" @default.
- W4364377100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37058941" @default.
- W4364377100 hasPublicationYear "2023" @default.
- W4364377100 type Work @default.
- W4364377100 citedByCount "1" @default.
- W4364377100 countsByYear W43643771002023 @default.
- W4364377100 crossrefType "journal-article" @default.
- W4364377100 hasAuthorship W4364377100A5000703206 @default.
- W4364377100 hasAuthorship W4364377100A5010470792 @default.
- W4364377100 hasAuthorship W4364377100A5021852002 @default.
- W4364377100 hasAuthorship W4364377100A5058587719 @default.
- W4364377100 hasAuthorship W4364377100A5058777439 @default.
- W4364377100 hasAuthorship W4364377100A5070705465 @default.
- W4364377100 hasAuthorship W4364377100A5077094802 @default.
- W4364377100 hasConcept C104317684 @default.
- W4364377100 hasConcept C121608353 @default.
- W4364377100 hasConcept C124535831 @default.
- W4364377100 hasConcept C126322002 @default.
- W4364377100 hasConcept C143998085 @default.
- W4364377100 hasConcept C185592680 @default.
- W4364377100 hasConcept C2781197716 @default.
- W4364377100 hasConcept C46111723 @default.
- W4364377100 hasConcept C502942594 @default.
- W4364377100 hasConcept C526805850 @default.
- W4364377100 hasConcept C55493867 @default.
- W4364377100 hasConcept C60644358 @default.
- W4364377100 hasConcept C70721500 @default.
- W4364377100 hasConcept C71924100 @default.
- W4364377100 hasConcept C86803240 @default.
- W4364377100 hasConceptScore W4364377100C104317684 @default.
- W4364377100 hasConceptScore W4364377100C121608353 @default.
- W4364377100 hasConceptScore W4364377100C124535831 @default.
- W4364377100 hasConceptScore W4364377100C126322002 @default.
- W4364377100 hasConceptScore W4364377100C143998085 @default.
- W4364377100 hasConceptScore W4364377100C185592680 @default.
- W4364377100 hasConceptScore W4364377100C2781197716 @default.
- W4364377100 hasConceptScore W4364377100C46111723 @default.
- W4364377100 hasConceptScore W4364377100C502942594 @default.
- W4364377100 hasConceptScore W4364377100C526805850 @default.
- W4364377100 hasConceptScore W4364377100C55493867 @default.
- W4364377100 hasConceptScore W4364377100C60644358 @default.
- W4364377100 hasConceptScore W4364377100C70721500 @default.
- W4364377100 hasConceptScore W4364377100C71924100 @default.
- W4364377100 hasConceptScore W4364377100C86803240 @default.
- W4364377100 hasLocation W43643771001 @default.
- W4364377100 hasLocation W43643771002 @default.
- W4364377100 hasOpenAccess W4364377100 @default.
- W4364377100 hasPrimaryLocation W43643771001 @default.