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- W4364378412 abstract "<p> </p> <p><strong>Objective:</strong> Long noncoding RNAs (lncRNAs) are involved in diabetogenesis in experimental models yet their role in humans is unclear. We investigated whether circulating lncRNAs associate with incident type 2 diabetes in older adults.</p> <p><strong>Research Design and Methods: </strong>A preselected panel of lncRNAs was measured in serum of individuals without diabetes (<em>n</em>=296) from the VIenna Transdanube Aging (VITA) study, a prospective community-based cohort study. Participants were followed-up over 7.5 years. A second cohort of individuals with and without type 2 diabetes (<em>n</em>=90) was employed to validate our findings.</p> <p><strong>Results:</strong> Four lncRNAs (ANRIL, MIAT, RNCR3, and PLUTO) were associated with incident type 2 diabetes and linked to HbA1c trajectories throughout the 7.5-year follow-up. Similar results (for MIAT and PLUTO also in combined analysis) were obtained in the validation cohort.</p> <p><strong>Conclusion:</strong> We found a set of circulating lncRNAs which independently portends incident type 2 diabetes in older adults years before disease onset.</p>" @default.
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- W4364378412 date "2023-04-11" @default.
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- W4364378412 title "Circulating long noncoding RNA signatures associate with incident diabetes in older adults: a prospective analysis from the VITA cohort study" @default.
- W4364378412 doi "https://doi.org/10.2337/figshare.22350793" @default.
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