FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4364860996> ?p ?o ?g. }

• W4364860996 endingPage "1023" @default.
• W4364860996 startingPage "1011" @default.
• W4364860996 abstract "Background: Ovarian cancer is the most malignant gynecological disease, which seriously threatens female physical and mental health. Paclitaxel is a first-line chemotherapy drug in the clinical treatment of ovarian cancer, but drug resistance has become an important factor affecting the survival of ovarian cancer patients. However, the main mechanism of chemotherapy resistance in ovarian cancer remains unclear. In this study, we analyzed the Integrated Gene Expression Database (GEO) dataset using comprehensive bioinformatics tools to provide new therapeutic strategies and search for prognostic targets for ovarian cancer. Methods: Ovarian cancer related genes were extracted from GSE18520 by bioinformatics method. Differentially expressed genes (DEGs) were obtained by differential analysis, and related genes and functions were elucidated. The key gene CRTC2 was identified by prognostic analysis. Immunohistochemistry was used to detect the expression of CRTC2 in chemotherapy-resistant and chemotherapy-sensitive ovarian cancer tissues. Functional analysis (cell assay) confirmed the role of CRTC2 in paclitaxel resistance. Autophagy related proteins were detected by Western blot. Autophagy flux analysis was performed using the GFP/RFP-LC3 adenovirus reporter. Results: A total of 3,852 DEGs were identified in the GEO microarray dataset. Key genes were screened by prognostic analysis. We found that CRTC2 was highly expressed in chemoresistant tissues of ovarian cancer. In 110 patients with ovarian cancer, high expression of CRTC2 was associated with poorer prognostic factors and shorter survival. At the same time, we found that CRTC2 can promote the proliferation and invasion ability of ovarian cancer cells. In addition, CRTC2 can affect the expression of PI3K, AKT, autophagic flux and sensitivity to paclitaxel chemotherapy in ovarian cancer. Conclusion: CRTC2 can affect autophagy partially through PI3K-AKT signaling pathway, and then affect the sensitivity of ovarian cancer to paclitaxel chemotherapy. CRTC2 may be a potential predictor or target for ovarian cancer therapy." @default.
• W4364860996 created "2023-04-13" @default.
• W4364860996 creator A5013652689 @default.
• W4364860996 creator A5025954006 @default.
• W4364860996 creator A5035982919 @default.
• W4364860996 creator A5039790968 @default.
• W4364860996 creator A5066716873 @default.
• W4364860996 creator A5071859602 @default.
• W4364860996 creator A5071965222 @default.
• W4364860996 creator A5072186094 @default.
• W4364860996 date "2023-01-01" @default.
• W4364860996 modified "2023-10-05" @default.
• W4364860996 title "CRTC2 promotes paclitaxel resistance by inducing autophagy in ovarian cancer in part via the PI3K-AKT signaling axis" @default.
• W4364860996 cites W1163643844 @default.
• W4364860996 cites W2038091455 @default.
• W4364860996 cites W2044221321 @default.
• W4364860996 cites W2045088439 @default.
• W4364860996 cites W2045154939 @default.
• W4364860996 cites W2054078002 @default.
• W4364860996 cites W2061473417 @default.
• W4364860996 cites W2066662062 @default.
• W4364860996 cites W2099521317 @default.
• W4364860996 cites W2109658497 @default.
• W4364860996 cites W2110025151 @default.
• W4364860996 cites W2110103048 @default.
• W4364860996 cites W2112668580 @default.
• W4364860996 cites W2122952432 @default.
• W4364860996 cites W2140689118 @default.
• W4364860996 cites W2206282186 @default.
• W4364860996 cites W2597637198 @default.
• W4364860996 cites W2765111086 @default.
• W4364860996 cites W2793964713 @default.
• W4364860996 cites W2799652446 @default.
• W4364860996 cites W2801961870 @default.
• W4364860996 cites W2918832315 @default.
• W4364860996 cites W2922503148 @default.
• W4364860996 cites W2963425570 @default.
• W4364860996 cites W2980216096 @default.
• W4364860996 cites W2996498230 @default.
• W4364860996 cites W2999417355 @default.
• W4364860996 cites W3033132033 @default.
• W4364860996 cites W3089810979 @default.
• W4364860996 cites W3124179740 @default.
• W4364860996 cites W3137568497 @default.
• W4364860996 cites W3162146425 @default.
• W4364860996 cites W4225159531 @default.
• W4364860996 doi "https://doi.org/10.7150/jca.82233" @default.
• W4364860996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37151390" @default.
• W4364860996 hasPublicationYear "2023" @default.
• W4364860996 type Work @default.
• W4364860996 citedByCount "0" @default.
• W4364860996 crossrefType "journal-article" @default.
• W4364860996 hasAuthorship W4364860996A5013652689 @default.
• W4364860996 hasAuthorship W4364860996A5025954006 @default.
• W4364860996 hasAuthorship W4364860996A5035982919 @default.
• W4364860996 hasAuthorship W4364860996A5039790968 @default.
• W4364860996 hasAuthorship W4364860996A5066716873 @default.
• W4364860996 hasAuthorship W4364860996A5071859602 @default.
• W4364860996 hasAuthorship W4364860996A5071965222 @default.
• W4364860996 hasAuthorship W4364860996A5072186094 @default.
• W4364860996 hasBestOaLocation W43648609961 @default.
• W4364860996 hasConcept C121608353 @default.
• W4364860996 hasConcept C126322002 @default.
• W4364860996 hasConcept C143998085 @default.
• W4364860996 hasConcept C190283241 @default.
• W4364860996 hasConcept C203522944 @default.
• W4364860996 hasConcept C2777292972 @default.
• W4364860996 hasConcept C2780427987 @default.
• W4364860996 hasConcept C502942594 @default.
• W4364860996 hasConcept C54355233 @default.
• W4364860996 hasConcept C71924100 @default.
• W4364860996 hasConcept C86803240 @default.
• W4364860996 hasConceptScore W4364860996C121608353 @default.
• W4364860996 hasConceptScore W4364860996C126322002 @default.
• W4364860996 hasConceptScore W4364860996C143998085 @default.
• W4364860996 hasConceptScore W4364860996C190283241 @default.
• W4364860996 hasConceptScore W4364860996C203522944 @default.
• W4364860996 hasConceptScore W4364860996C2777292972 @default.
• W4364860996 hasConceptScore W4364860996C2780427987 @default.
• W4364860996 hasConceptScore W4364860996C502942594 @default.
• W4364860996 hasConceptScore W4364860996C54355233 @default.
• W4364860996 hasConceptScore W4364860996C71924100 @default.
• W4364860996 hasConceptScore W4364860996C86803240 @default.
• W4364860996 hasIssue "6" @default.
• W4364860996 hasLocation W43648609961 @default.
• W4364860996 hasLocation W43648609962 @default.
• W4364860996 hasLocation W43648609963 @default.
• W4364860996 hasOpenAccess W4364860996 @default.
• W4364860996 hasPrimaryLocation W43648609961 @default.
• W4364860996 hasRelatedWork W1970921743 @default.
• W4364860996 hasRelatedWork W2177319586 @default.
• W4364860996 hasRelatedWork W2320097775 @default.
• W4364860996 hasRelatedWork W2328421677 @default.
• W4364860996 hasRelatedWork W2407545117 @default.
• W4364860996 hasRelatedWork W2415960870 @default.
• W4364860996 hasRelatedWork W2443311901 @default.
• W4364860996 hasRelatedWork W2466209479 @default.
• W4364860996 hasRelatedWork W2489762468 @default.

• next