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• W4364861992 startingPage "325" @default.
• W4364861992 abstract "Due to the complexity of cancer treatment, there is a need to embrace more advanced approaches in cancer therapy. Targeted therapies are cancer treatment that targets proteins and enzymes that affect how cancer cells grow, divide, and disseminate. The specificity of targeted therapies is essential in understanding the most effective way to treat cancer. Previous proteomics and enzymatic studies have revealed some essential proteins and enzymes actively involved in cancer cells’ growth, division, or dissemination. Some of these proteins and enzymes include; glucose transporter 1, which undertakes the function of supplying glucose to cells; hexokinase 2, which enhances glycolytic rate; phosphoglucose isomerase and glyceraldehyde 3-phosphate dehydrogenase, which performs supplementary actions in boosting the growth of tumor in an unglycolytic manner; Tyrosine kinases,Tyrosine kinase which play an essential role in transduction steps mediation, causing proliferation of the cell, differentiation, migration, metabolism, and programmed cell death. Computer-aided drug designComputer-Aided Drug Design and advancements in this area have made it possible to have these essential proteins and enzymes involved in cancer in a 3D format present in databasesDatabase that can be used in in silico drug design that target specific proteins and enzymes. With the computer-aided drug designComputer-Aided Drug Design, databasesDatabase can be utilized in novel drug design for cancer treatments through computer-assisted structure–activity relationship studies, in silicodrug-likenessDruglikeness prediction, in silicoADMETADMET studies, molecular docking simulationMolecular docking simulation, molecular dynamicsMolecular dynamics studies, and other in silico studies targeted drug development. These methods can hasten the course of new drug development and repurposing, thereby minimizing the likelihood of drug candidates failing in the phases of drug development." @default.
• W4364861992 created "2023-04-13" @default.
• W4364861992 creator A5014006299 @default.
• W4364861992 creator A5067316413 @default.
• W4364861992 creator A5072748565 @default.
• W4364861992 creator A5087526866 @default.
• W4364861992 date "2023-01-01" @default.
• W4364861992 modified "2023-09-27" @default.
• W4364861992 title "CADD for Cancer Therapy: Current and Future Perspective" @default.
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