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• W4364862013 abstract "Cancer drugs fail in clinical trials at a rate of more than 90% due to infiltration of myofibroblast, fibroblast, and an increase in collagen, resulting in a poor prognosis. Cancer tissues have a tumor microenvironment (TME) that is made up of cancerous and noncancerous cells, growth factors, extracellular matrix (ECM), and other substances. Tumor cells’ ECM is constantly remodeled to increase stiffness, survival, proliferation, and immunosuppression. Most of the studies involve cellular models in vitro, which many a times are grown as 2D cultures. Many features are lost in vitro because of continuous ECM remodeling. To overcome this, decellularized scaffolds known as decellularized tumor ECM (dt-ECM) are used, which retain composition as well as mechanical structure. They have the potential to be a very useful tool in understanding cancer progression and formation. One of the powerful approaches to understand diseases is tissue engineering, which is a culmination cell biology, developmental biology, nanobiotechnology, material science, and related fields. Tissue engineering assists researchers in producing engineered and functional cells that will give rise to tissues, which might then go on to become organs. Engineered tissues and organoids (miniature forms) are used in drug development, screening, and disease modeling. The 3D tissue model is useful in understanding various diseases. Organoids are miniature versions of organs that are used to reduce animal usage and to develop body-on-a-chip or organ-on-a-chip. They can help to support tumor heterogeneity, which will aid in personalized medicine and reduce the likelihood of drug failure. While growing cells to 3D tissues is quite interesting, finding the right type of scaffolds is equally important, which might play major role in cell adhesion, cell motility, cell differentiation, etc. Alginate with RGD and other biomaterials, for example, has been a major focus due to important properties demonstrated by alginate that aid in cancer research. Since 3D engineered organs and tissues require an environment similar to in vivo, advanced bioreactors are being developed. Tissue-engineered organs will aid in drug screening, development of more effective drugs, and, most importantly, understanding of cancer. Recently, the use of microfluidics system which is combination of microelectronics and TE looks very promising; it offers more advantages than 3D and 2D culture. It comes with various application like study of metastasis cancer which is main causative of cancer death across the world. Integration of nanotechnology in TE helps in building new biomaterials which have shown enhanced cell adhesion and various other properties. There are various 3D models which have been developed to study and understand different types of cancer." @default.
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• W4364862013 date "2023-01-01" @default.
• W4364862013 modified "2023-09-27" @default.
• W4364862013 title "Exploration of Tissue-Engineered Systems for Cancer Research" @default.
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• W4364862013 doi "https://doi.org/10.1007/978-981-19-9786-0_3" @default.
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