Matches in SemOpenAlex for { <https://semopenalex.org/work/W4365140212> ?p ?o ?g. }
- W4365140212 abstract "While skin is a site of active immune surveillance, primary melanomas often escape detection. Here, we have developed an in silico model to determine the local cross-talk between melanomas and Langerhans cells (LCs), the primary antigen-presenting cells at the site of melanoma development. The model predicts that melanomas fail to activate LC migration to lymph nodes until tumors reach a critical size, which is determined by a positive TNF-α feedback loop within melanomas, in line with our observations of murine tumors. In silico drug screening, supported by subsequent experimental testing, shows that treatment of primary tumors with MAPK pathway inhibitors may further prevent LC migration. In addition, our in silico model predicts treatment combinations that bypass LC dysfunction. In conclusion, our combined approach of in silico and in vivo studies suggests a molecular mechanism that explains how early melanomas develop under the radar of immune surveillance by LC." @default.
- W4365140212 created "2023-04-13" @default.
- W4365140212 creator A5013111182 @default.
- W4365140212 creator A5038269053 @default.
- W4365140212 creator A5042917669 @default.
- W4365140212 creator A5047444998 @default.
- W4365140212 creator A5050062882 @default.
- W4365140212 creator A5064997315 @default.
- W4365140212 creator A5073516232 @default.
- W4365140212 creator A5081754361 @default.
- W4365140212 creator A5084475823 @default.
- W4365140212 creator A5086492427 @default.
- W4365140212 date "2023-04-14" @default.
- W4365140212 modified "2023-09-25" @default.
- W4365140212 title "Localized immune surveillance of primary melanoma in the skin deciphered through executable modeling" @default.
- W4365140212 cites W1484940923 @default.
- W4365140212 cites W1531737911 @default.
- W4365140212 cites W1550772045 @default.
- W4365140212 cites W1570700782 @default.
- W4365140212 cites W1575657391 @default.
- W4365140212 cites W1788683850 @default.
- W4365140212 cites W1853698148 @default.
- W4365140212 cites W1950829641 @default.
- W4365140212 cites W1967902354 @default.
- W4365140212 cites W1967909721 @default.
- W4365140212 cites W1969717303 @default.
- W4365140212 cites W1973917430 @default.
- W4365140212 cites W1980415043 @default.
- W4365140212 cites W1982635732 @default.
- W4365140212 cites W1983398917 @default.
- W4365140212 cites W1985928174 @default.
- W4365140212 cites W1986397618 @default.
- W4365140212 cites W1986426976 @default.
- W4365140212 cites W1986963741 @default.
- W4365140212 cites W1994103354 @default.
- W4365140212 cites W1994581225 @default.
- W4365140212 cites W1997795769 @default.
- W4365140212 cites W2010547812 @default.
- W4365140212 cites W2015009944 @default.
- W4365140212 cites W2018310864 @default.
- W4365140212 cites W2019544036 @default.
- W4365140212 cites W2020404856 @default.
- W4365140212 cites W2022556924 @default.
- W4365140212 cites W2024449289 @default.
- W4365140212 cites W2028260968 @default.
- W4365140212 cites W2029910090 @default.
- W4365140212 cites W2032099289 @default.
- W4365140212 cites W2034717053 @default.
- W4365140212 cites W2036380540 @default.
- W4365140212 cites W2037783385 @default.
- W4365140212 cites W2039620484 @default.
- W4365140212 cites W2040286515 @default.
- W4365140212 cites W2041255253 @default.
- W4365140212 cites W2043514557 @default.
- W4365140212 cites W2049110650 @default.
- W4365140212 cites W2050839565 @default.
- W4365140212 cites W2052005627 @default.
- W4365140212 cites W2052474826 @default.
- W4365140212 cites W2058390096 @default.
- W4365140212 cites W2058680810 @default.
- W4365140212 cites W2064475159 @default.
- W4365140212 cites W2064784982 @default.
- W4365140212 cites W2065620201 @default.
- W4365140212 cites W2066290706 @default.
- W4365140212 cites W2069877315 @default.
- W4365140212 cites W2070260068 @default.
- W4365140212 cites W2078370873 @default.
- W4365140212 cites W2080686146 @default.
- W4365140212 cites W2086811944 @default.
- W4365140212 cites W2094397925 @default.
- W4365140212 cites W2096860625 @default.
- W4365140212 cites W2102448788 @default.
- W4365140212 cites W2103557568 @default.
- W4365140212 cites W2104877706 @default.
- W4365140212 cites W2108129909 @default.
- W4365140212 cites W2109351911 @default.
- W4365140212 cites W2110682642 @default.
- W4365140212 cites W2116677194 @default.
- W4365140212 cites W2119616623 @default.
- W4365140212 cites W2122902176 @default.
- W4365140212 cites W2127956110 @default.
- W4365140212 cites W2131001269 @default.
- W4365140212 cites W2131040858 @default.
- W4365140212 cites W2136453810 @default.
- W4365140212 cites W2137577162 @default.
- W4365140212 cites W2142400903 @default.
- W4365140212 cites W2142596863 @default.
- W4365140212 cites W2143580209 @default.
- W4365140212 cites W2145482514 @default.
- W4365140212 cites W2146620745 @default.
- W4365140212 cites W2150740687 @default.
- W4365140212 cites W2151136040 @default.
- W4365140212 cites W2157873170 @default.
- W4365140212 cites W2158416296 @default.
- W4365140212 cites W2158880256 @default.
- W4365140212 cites W2159969192 @default.
- W4365140212 cites W2161513388 @default.
- W4365140212 cites W2162125815 @default.
- W4365140212 cites W2163638464 @default.
- W4365140212 cites W2166132142 @default.