FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4365144182> ?p ?o ?g. }

• W4365144182 endingPage "810.e7" @default.
• W4365144182 startingPage "798" @default.
• W4365144182 abstract "•F. nucleatum is enriched in the gut of RA patients and associated with RA severity •F. nucleatum aggravates arthritis by delivering FadA to the joints via OMVs •FadA triggers synovial inflammation by activating Rab5a-YB-1 in synovial macrophages •An elevated FadA-Rab5a-YB-1 axis is observed in the synovium of RA patients Rheumatoid arthritis (RA) is an autoimmune disorder that has been associated with the gut microbiota. However, whether and how the gut microbiota plays a pathogenic role in RA remains unexplored. Here, we observed that Fusobacterium nucleatum is enriched in RA patients and positively associated with RA severity. F. nucleatum similarly aggravates arthritis in a mouse model of collagen-induced arthritis (CIA). F. nucleatum outer membrane vesicles (OMVs) containing the virulence determinant FadA translocate into the joints, triggering local inflammatory responses. Specifically, FadA acts on synovial macrophages, resulting in the activation of the Rab5a GTPase involved in vesicle trafficking and inflammatory pathways and YB-1, a key regulator of inflammatory mediators. OMVs containing FadA and heightened Rab5a-YB-1 expression were observed in RA patients compared with controls. These findings suggest a causal role of F. nucleatum in aggravating RA and provide promising therapeutic targets for clinically ameliorating RA. Rheumatoid arthritis (RA) is an autoimmune disorder that has been associated with the gut microbiota. However, whether and how the gut microbiota plays a pathogenic role in RA remains unexplored. Here, we observed that Fusobacterium nucleatum is enriched in RA patients and positively associated with RA severity. F. nucleatum similarly aggravates arthritis in a mouse model of collagen-induced arthritis (CIA). F. nucleatum outer membrane vesicles (OMVs) containing the virulence determinant FadA translocate into the joints, triggering local inflammatory responses. Specifically, FadA acts on synovial macrophages, resulting in the activation of the Rab5a GTPase involved in vesicle trafficking and inflammatory pathways and YB-1, a key regulator of inflammatory mediators. OMVs containing FadA and heightened Rab5a-YB-1 expression were observed in RA patients compared with controls. These findings suggest a causal role of F. nucleatum in aggravating RA and provide promising therapeutic targets for clinically ameliorating RA." @default.
• W4365144182 created "2023-04-13" @default.
• W4365144182 creator A5004090945 @default.
• W4365144182 creator A5009831782 @default.
• W4365144182 creator A5020950137 @default.
• W4365144182 creator A5022802322 @default.
• W4365144182 creator A5028256763 @default.
• W4365144182 creator A5032903359 @default.
• W4365144182 creator A5047839791 @default.
• W4365144182 creator A5050431728 @default.
• W4365144182 creator A5052872828 @default.
• W4365144182 creator A5058361424 @default.
• W4365144182 creator A5062688774 @default.
• W4365144182 creator A5064194617 @default.
• W4365144182 creator A5064711465 @default.
• W4365144182 creator A5070231893 @default.
• W4365144182 creator A5076822379 @default.
• W4365144182 creator A5079887522 @default.
• W4365144182 date "2023-05-01" @default.
• W4365144182 modified "2023-10-12" @default.
• W4365144182 title "Fusobacterium nucleatum aggravates rheumatoid arthritis through FadA-containing outer membrane vesicles" @default.
• W4365144182 cites W2006292369 @default.
• W4365144182 cites W2021161135 @default.
• W4365144182 cites W2035618305 @default.
• W4365144182 cites W2037199116 @default.
• W4365144182 cites W2072970694 @default.
• W4365144182 cites W2097823370 @default.
• W4365144182 cites W2110826367 @default.
• W4365144182 cites W2113552312 @default.
• W4365144182 cites W2117233882 @default.
• W4365144182 cites W2134526812 @default.
• W4365144182 cites W2136879569 @default.
• W4365144182 cites W2155972247 @default.
• W4365144182 cites W2157107905 @default.
• W4365144182 cites W2160524419 @default.
• W4365144182 cites W2169456326 @default.
• W4365144182 cites W2179438025 @default.
• W4365144182 cites W2203974053 @default.
• W4365144182 cites W2345407464 @default.
• W4365144182 cites W2346233234 @default.
• W4365144182 cites W2508695471 @default.
• W4365144182 cites W2537258608 @default.
• W4365144182 cites W2681129802 @default.
• W4365144182 cites W2742147437 @default.
• W4365144182 cites W2758170246 @default.
• W4365144182 cites W2768799378 @default.
• W4365144182 cites W2790669451 @default.
• W4365144182 cites W2899663373 @default.
• W4365144182 cites W2904988746 @default.
• W4365144182 cites W2916308866 @default.
• W4365144182 cites W2937164721 @default.
• W4365144182 cites W2963276645 @default.
• W4365144182 cites W2976719148 @default.
• W4365144182 cites W2995055179 @default.
• W4365144182 cites W2997780966 @default.
• W4365144182 cites W3005678666 @default.
• W4365144182 cites W3010662671 @default.
• W4365144182 cites W3013317600 @default.
• W4365144182 cites W3016349400 @default.
• W4365144182 cites W3037222958 @default.
• W4365144182 cites W3096025828 @default.
• W4365144182 cites W3122498722 @default.
• W4365144182 cites W3129543088 @default.
• W4365144182 cites W3133232611 @default.
• W4365144182 cites W3135922797 @default.
• W4365144182 cites W3138215020 @default.
• W4365144182 cites W3174825538 @default.
• W4365144182 cites W3202430666 @default.
• W4365144182 cites W3206785112 @default.
• W4365144182 cites W4210913993 @default.
• W4365144182 cites W4220696121 @default.
• W4365144182 cites W4220901250 @default.
• W4365144182 cites W4280596534 @default.
• W4365144182 cites W4292641264 @default.
• W4365144182 cites W4308061335 @default.
• W4365144182 doi "https://doi.org/10.1016/j.chom.2023.03.018" @default.
• W4365144182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37054714" @default.
• W4365144182 hasPublicationYear "2023" @default.
• W4365144182 type Work @default.
• W4365144182 citedByCount "4" @default.
• W4365144182 countsByYear W43651441822023 @default.
• W4365144182 crossrefType "journal-article" @default.
• W4365144182 hasAuthorship W4365144182A5004090945 @default.
• W4365144182 hasAuthorship W4365144182A5009831782 @default.
• W4365144182 hasAuthorship W4365144182A5020950137 @default.
• W4365144182 hasAuthorship W4365144182A5022802322 @default.
• W4365144182 hasAuthorship W4365144182A5028256763 @default.
• W4365144182 hasAuthorship W4365144182A5032903359 @default.
• W4365144182 hasAuthorship W4365144182A5047839791 @default.
• W4365144182 hasAuthorship W4365144182A5050431728 @default.
• W4365144182 hasAuthorship W4365144182A5052872828 @default.
• W4365144182 hasAuthorship W4365144182A5058361424 @default.
• W4365144182 hasAuthorship W4365144182A5062688774 @default.
• W4365144182 hasAuthorship W4365144182A5064194617 @default.
• W4365144182 hasAuthorship W4365144182A5064711465 @default.
• W4365144182 hasAuthorship W4365144182A5070231893 @default.
• W4365144182 hasAuthorship W4365144182A5076822379 @default.
• W4365144182 hasAuthorship W4365144182A5079887522 @default.

• next