Matches in SemOpenAlex for { <https://semopenalex.org/work/W4365145518> ?p ?o ?g. }
- W4365145518 endingPage "739" @default.
- W4365145518 startingPage "739" @default.
- W4365145518 abstract "Infections caused by resistant strains of Acinetobacter baumannii are now a global problem that requires the immediate development of new antimicrobial drugs. Combination therapy is one of the strategies used to solve this problem. Based on this information, the purpose of this study was to determine whether quercetin (QUE), in combination with three antibiotics, is effective against colistin-resistant A. baumannii strains (ColR-Ab). The effects of the combination of QUE with colistin (COL), amikacin (AMK), and meropenem (MEM) were evaluated according to the checkerboard synergy test. The combinations of QUE + COL and QUE + AMK showed synergistic activity on ColR-Ab strains with FICI values in the range of 0.1875-0.5 and 0.1875-0.2825, respectively. A 4- to 16-fold decrease in COL MIC and a 16- to 64-fold decrease in AMK MIC values were detected. Synergistic activity was confirmed by the time-kill test, and these combinations were found to be bactericidal at the end of 24 h. According to spectrophotometric measurements, the combinations of QUE + COL and QUE + AMK induced membrane damage, leading to the leakage of nucleic acids. Cell lysis and cell death were confirmed with SEM observations. The detected synergy offers an opportunity for the future development of treatment strategies for potential infections caused by ColR-Ab strains." @default.
- W4365145518 created "2023-04-13" @default.
- W4365145518 creator A5010161335 @default.
- W4365145518 creator A5017656651 @default.
- W4365145518 creator A5033863215 @default.
- W4365145518 creator A5039201172 @default.
- W4365145518 creator A5049897705 @default.
- W4365145518 creator A5091032719 @default.
- W4365145518 date "2023-04-12" @default.
- W4365145518 modified "2023-09-30" @default.
- W4365145518 title "Quercetin: Synergistic Interaction with Antibiotics against Colistin-Resistant Acinetobacter baumannii" @default.
- W4365145518 cites W1843153480 @default.
- W4365145518 cites W1981609178 @default.
- W4365145518 cites W1991386043 @default.
- W4365145518 cites W1999055779 @default.
- W4365145518 cites W2009666276 @default.
- W4365145518 cites W2023625688 @default.
- W4365145518 cites W2042595125 @default.
- W4365145518 cites W2047365652 @default.
- W4365145518 cites W2052130550 @default.
- W4365145518 cites W2082883781 @default.
- W4365145518 cites W2118970688 @default.
- W4365145518 cites W2138137693 @default.
- W4365145518 cites W2145252474 @default.
- W4365145518 cites W2159435953 @default.
- W4365145518 cites W2262769374 @default.
- W4365145518 cites W2305267718 @default.
- W4365145518 cites W2499911733 @default.
- W4365145518 cites W2578361705 @default.
- W4365145518 cites W2594303706 @default.
- W4365145518 cites W2765689799 @default.
- W4365145518 cites W2778059707 @default.
- W4365145518 cites W2811106727 @default.
- W4365145518 cites W2811512821 @default.
- W4365145518 cites W2883041905 @default.
- W4365145518 cites W2917427100 @default.
- W4365145518 cites W2924930352 @default.
- W4365145518 cites W2956821000 @default.
- W4365145518 cites W2982531295 @default.
- W4365145518 cites W2990005651 @default.
- W4365145518 cites W2997032704 @default.
- W4365145518 cites W3011514911 @default.
- W4365145518 cites W3011995344 @default.
- W4365145518 cites W3012097929 @default.
- W4365145518 cites W3018857444 @default.
- W4365145518 cites W3096855089 @default.
- W4365145518 cites W3096978385 @default.
- W4365145518 cites W3113913409 @default.
- W4365145518 cites W3124564098 @default.
- W4365145518 cites W3135668562 @default.
- W4365145518 cites W3156856774 @default.
- W4365145518 cites W3164191103 @default.
- W4365145518 cites W3191976887 @default.
- W4365145518 cites W3207421551 @default.
- W4365145518 cites W3208203763 @default.
- W4365145518 cites W3216134624 @default.
- W4365145518 cites W4224321662 @default.
- W4365145518 cites W4294343769 @default.
- W4365145518 doi "https://doi.org/10.3390/antibiotics12040739" @default.
- W4365145518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37107101" @default.
- W4365145518 hasPublicationYear "2023" @default.
- W4365145518 type Work @default.
- W4365145518 citedByCount "1" @default.
- W4365145518 countsByYear W43651455182023 @default.
- W4365145518 crossrefType "journal-article" @default.
- W4365145518 hasAuthorship W4365145518A5010161335 @default.
- W4365145518 hasAuthorship W4365145518A5017656651 @default.
- W4365145518 hasAuthorship W4365145518A5033863215 @default.
- W4365145518 hasAuthorship W4365145518A5039201172 @default.
- W4365145518 hasAuthorship W4365145518A5049897705 @default.
- W4365145518 hasAuthorship W4365145518A5091032719 @default.
- W4365145518 hasBestOaLocation W43651455181 @default.
- W4365145518 hasConcept C185592680 @default.
- W4365145518 hasConcept C2776315533 @default.
- W4365145518 hasConcept C2777427914 @default.
- W4365145518 hasConcept C2777637488 @default.
- W4365145518 hasConcept C2779259085 @default.
- W4365145518 hasConcept C2779375183 @default.
- W4365145518 hasConcept C4937899 @default.
- W4365145518 hasConcept C501593827 @default.
- W4365145518 hasConcept C523546767 @default.
- W4365145518 hasConcept C54355233 @default.
- W4365145518 hasConcept C86803240 @default.
- W4365145518 hasConcept C89423630 @default.
- W4365145518 hasConcept C94665300 @default.
- W4365145518 hasConceptScore W4365145518C185592680 @default.
- W4365145518 hasConceptScore W4365145518C2776315533 @default.
- W4365145518 hasConceptScore W4365145518C2777427914 @default.
- W4365145518 hasConceptScore W4365145518C2777637488 @default.
- W4365145518 hasConceptScore W4365145518C2779259085 @default.
- W4365145518 hasConceptScore W4365145518C2779375183 @default.
- W4365145518 hasConceptScore W4365145518C4937899 @default.
- W4365145518 hasConceptScore W4365145518C501593827 @default.
- W4365145518 hasConceptScore W4365145518C523546767 @default.
- W4365145518 hasConceptScore W4365145518C54355233 @default.
- W4365145518 hasConceptScore W4365145518C86803240 @default.
- W4365145518 hasConceptScore W4365145518C89423630 @default.
- W4365145518 hasConceptScore W4365145518C94665300 @default.