FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4365148043> ?p ?o ?g. }

• W4365148043 endingPage "3389" @default.
• W4365148043 startingPage "3389" @default.
• W4365148043 abstract "Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype of breast cancer. Curcumol, as a natural small molecule compound, has potential anti-breast cancer activity. In this study, we chemically synthesized a derivative of curcumol, named HCL-23, by structural modification and explored its effect on and underlying mechanism regarding TNBC progression. MTT and colony formation assays demonstrated that HCL-23 significantly inhibited TNBC cells proliferation. HCL-23 induced G2/M phase cell cycle arrest and repressed the capability of migration, invasion, and adhesion in MDA-MB-231 cells. RNA-seq results identified 990 differentially expressed genes including 366 upregulated and 624 downregulated genes. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Set Enrichment Analysis (GSEA) revealed that these differentially expressed genes were obviously enriched in adhesion, cell migration, apoptosis, and ferroptosis. Furthermore, HCL-23 induced apoptosis via the loss of mitochondrial membrane potential and the activation of the caspase family in TNBC cells. In addition, HCL-23 was verified to trigger ferroptosis through increasing cellular reactive oxygen species (ROS), labile iron pool (LIP), and lipid peroxidation levels. Mechanistically, HCL-23 markedly upregulated the expression of heme oxygenase 1 (HO-1), and the knockdown of HO-1 could attenuate ferroptosis induced by HCL-23. In animal experiments, we found that HCL-23 inhibited tumor growth and weight. Consistently, the upregulation of Cleaved Caspase-3, Cleaved PARP, and HO-1 expression was also observed in tumor tissues treated with HCL-23. In summary, the above results suggest that HCL-23 can promote cell death through activating caspases-mediated apoptosis and HO-1-dependent ferroptosis in TNBC. Therefore, our findings provide a new potential agent against TNBC." @default.
• W4365148043 created "2023-04-13" @default.
• W4365148043 creator A5002239035 @default.
• W4365148043 creator A5013345235 @default.
• W4365148043 creator A5021449466 @default.
• W4365148043 creator A5023362563 @default.
• W4365148043 creator A5052634376 @default.
• W4365148043 creator A5060890485 @default.
• W4365148043 creator A5064518854 @default.
• W4365148043 creator A5067411192 @default.
• W4365148043 creator A5075902735 @default.
• W4365148043 creator A5079252184 @default.
• W4365148043 creator A5082449752 @default.
• W4365148043 creator A5085097733 @default.
• W4365148043 creator A5085288702 @default.
• W4365148043 creator A5090586653 @default.
• W4365148043 date "2023-04-12" @default.
• W4365148043 modified "2023-09-26" @default.
• W4365148043 title "A Novel Derivative of Curcumol, HCL-23, Inhibits the Malignant Phenotype of Triple-Negative Breast Cancer and Induces Apoptosis and HO-1-Dependent Ferroptosis" @default.
• W4365148043 cites W1557410895 @default.
• W4365148043 cites W1884941416 @default.
• W4365148043 cites W1972636570 @default.
• W4365148043 cites W1996716971 @default.
• W4365148043 cites W1997183854 @default.
• W4365148043 cites W2031915872 @default.
• W4365148043 cites W2055865889 @default.
• W4365148043 cites W2119003936 @default.
• W4365148043 cites W2129420347 @default.
• W4365148043 cites W2163792649 @default.
• W4365148043 cites W2165200432 @default.
• W4365148043 cites W2344189616 @default.
• W4365148043 cites W2592029987 @default.
• W4365148043 cites W2617444563 @default.
• W4365148043 cites W2810207377 @default.
• W4365148043 cites W2890536615 @default.
• W4365148043 cites W2908087395 @default.
• W4365148043 cites W2912993657 @default.
• W4365148043 cites W2915519736 @default.
• W4365148043 cites W2928665623 @default.
• W4365148043 cites W2935024989 @default.
• W4365148043 cites W2945901473 @default.
• W4365148043 cites W2948275501 @default.
• W4365148043 cites W3000273898 @default.
• W4365148043 cites W3003958110 @default.
• W4365148043 cites W3011366455 @default.
• W4365148043 cites W3015456794 @default.
• W4365148043 cites W3033869790 @default.
• W4365148043 cites W3082555410 @default.
• W4365148043 cites W3099343046 @default.
• W4365148043 cites W3100408440 @default.
• W4365148043 cites W3128302994 @default.
• W4365148043 cites W3128646645 @default.
• W4365148043 cites W3136285065 @default.
• W4365148043 cites W3139023802 @default.
• W4365148043 cites W3153729378 @default.
• W4365148043 cites W3163145088 @default.
• W4365148043 cites W3172339882 @default.
• W4365148043 cites W3174218465 @default.
• W4365148043 cites W3180766567 @default.
• W4365148043 cites W3200170043 @default.
• W4365148043 cites W3200818890 @default.
• W4365148043 cites W4205154707 @default.
• W4365148043 cites W4205724345 @default.
• W4365148043 cites W4213078955 @default.
• W4365148043 cites W4220831425 @default.
• W4365148043 cites W4224861896 @default.
• W4365148043 cites W4280496847 @default.
• W4365148043 cites W4281489782 @default.
• W4365148043 cites W4307771487 @default.
• W4365148043 cites W4307941291 @default.
• W4365148043 doi "https://doi.org/10.3390/molecules28083389" @default.
• W4365148043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37110625" @default.
• W4365148043 hasPublicationYear "2023" @default.
• W4365148043 type Work @default.
• W4365148043 citedByCount "0" @default.
• W4365148043 crossrefType "journal-article" @default.
• W4365148043 hasAuthorship W4365148043A5002239035 @default.
• W4365148043 hasAuthorship W4365148043A5013345235 @default.
• W4365148043 hasAuthorship W4365148043A5021449466 @default.
• W4365148043 hasAuthorship W4365148043A5023362563 @default.
• W4365148043 hasAuthorship W4365148043A5052634376 @default.
• W4365148043 hasAuthorship W4365148043A5060890485 @default.
• W4365148043 hasAuthorship W4365148043A5064518854 @default.
• W4365148043 hasAuthorship W4365148043A5067411192 @default.
• W4365148043 hasAuthorship W4365148043A5075902735 @default.
• W4365148043 hasAuthorship W4365148043A5079252184 @default.
• W4365148043 hasAuthorship W4365148043A5082449752 @default.
• W4365148043 hasAuthorship W4365148043A5085097733 @default.
• W4365148043 hasAuthorship W4365148043A5085288702 @default.
• W4365148043 hasAuthorship W4365148043A5090586653 @default.
• W4365148043 hasBestOaLocation W43651480431 @default.
• W4365148043 hasConcept C104317684 @default.
• W4365148043 hasConcept C121608353 @default.
• W4365148043 hasConcept C127561419 @default.
• W4365148043 hasConcept C150194340 @default.
• W4365148043 hasConcept C152724338 @default.
• W4365148043 hasConcept C153911025 @default.
• W4365148043 hasConcept C162317418 @default.

• next